Protein Alignment wnd and MAP3K9

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: XP_011535090.1
• Gene: MAP3K9 / 4293
• HGNCID: 6861
• Length: 1166
• Species: Homo sapiens
• Alignment Length: 1005
• Identity: 257/1005 - (25%)
• Similarity: 370/1005 - (36%)
• Gaps: 327/1005 - (32%)

  Fly   104 PPHVGGAGAAFGHPDK-------PIGWMYGLLGCMKPVLSFIG--------------KTG-VIEV 146
            ||...||||.....::       .:|  .|.|||..|:..:..              :.| |:||
Human    19 PPGEDGAGAGAEEEEEEEEEAAAAVG--PGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEV 81

  Fly   147 KSQRS-----EDW-------------------------------------------QIPFESITE 163
            .|:.|     |.|                                           :|.|..:|.
Human    82 LSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTL 146

  Fly   164 LEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDI-----------KHLRKLDHENIIKFKGVCT 217
            .|.:|.|..|.|:......:.||||..:...:.||           |....|.|.|||..:|||.
Human   147 EEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCL 211

  Fly   218 QSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSH---KIIHRDLKSPNIL 279
            :.|..|::|||...|||..:|..:::. |..||:|:.|||.||.|||..   .||||||||.|||
Human   212 KEPNLCLVMEFARGGPLNRVLSGKRIP-PDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNIL 275

  Fly   280 I--------STNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVL 336
            |        .:|:::||:|||.:|||:. :||||.|||.|||||||||....|:..|:|||||:|
Human   276 ILQKVENGDLSNKILKITDFGLAREWHR-TTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLL 339

  Fly   337 WEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSHLD 401
            ||:||.|:|::.:|..|:.:||..|.|.|.:||||||.|..|::.||...|.:||||..||.
Human   340 WELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILD--- 401

  Fly   402 IAGPELLRKTEKQYFE--------TQKSWKEEVRSHLKEITQNGTNIHKYEQDLIKRRTAEWRHA 458
                :|....|..:||        .|.:||.|::....::......:..:|::|.:.
Human   402 ----QLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRA-------- 454

  Fly   459 QDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAERERKLPGSGYKPNRRFGNTIRKMQHYRR 523
                     .||:.||  .||      |:.:|:|:||||                    :....|
Human   455 ---------ALQQKNQ--EEL------LRRREQELAERE--------------------IDILER 482

  Fly   524 RLNPAPAAIQQQSTTPDPETTPESPVKCMLYAQLDSNCQPKSYLANIIPSSGLGAPMPNKNKKVF 588
            .||                         ::..||   ||.|              |...|.|..|
Human   483 ELN-------------------------IIIHQL---CQEK--------------PRVKKRKGKF 505

  Fly   589 RHRR---NASGSFGAPPKY--------SPTRDRRYQSEPENRKVQLVERQTQTDAMDVSETDISP 642
            |..|   ........|..:        |||.|:|                          ..:..
Human   506 RKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKR--------------------------KSLIN 544

  Fly   643 SAEAPRSQPIDVPVPNHRQLPLQLQRVQKIAQAQARARSGSTSSAAGAVNPACPSNGNSLSTSEL 707
            |..:|.:.|..:|    |...:|.:.|.:|:..|         :..|.::||       ||:..|
Human   545 SRSSPPASPTIIP----RLRAIQCETVSQISWGQ---------NTQGHLSPA-------LSSHRL 589

  Fly   708 TYQDACSSPDQLIDDVMNSNERLDMTEC-----CSDNENLERLGRKVIEFINENRLSIQSNTNSV 767
            .  .|||         :::...|..|.|     .:..|:.:..||..:       :..:......
Human   590 V--QACS---------IHNFCHLSSTMCIYMHILTPGESSKTWGRSSV-------VPKEEGEEEE 636

  Fly   768 SNADNGNG---GASPLELRESGNSPCLSRCSSTHSKRRKHPLGDNPNGSSIGNANGESHEQDSWS 829
            ..|....|   |...|..:|..:                   ||..:......|||.|...:|..
Human   637 KRAPKKKGRTWGPGTLGQKELAS-------------------GDEGSPQRREKANGLSTPSESPH 682

  Fly   830 DEEGETT---DYKYALRRRSIGRQPIARGMRPRRSYKAP----LSQKIAIHKRNVVIVSDEEENT 887
            ...|..:   .||    :.|.....:.:|  ||.|...|    |.:...:....||.:..||:..
Human   683 FHLGLKSLVDGYK----QWSSSAPNLVKG--PRSSPALPGFTSLMEMALLAASWVVPIDIEEDED 741

  Fly   888 SEYSHSPSS--QHSTLESNTDIADMKKTQATSTSSNS-YSEPEDDSSDSSDEEQGNRPTEAKAEG 949
            ||...|..|  |||..:|...|...:.......||:. :.||...:|.:|..:.  .||.:...|
Human   742 SEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQL--TPTNSLKRG 804

  Fly   950 PA---------LPMGAVRSSDIISIPTFEA 970
            .|         |..|||.::..:.....||
Human   805 GAHHRRCEVALLGCGAVLAATGLGFDLLEA 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	115/257 (45%)
MAP3K9	XP_011535090.1	SH3_MLK1-3	56..113	CDD:212992	8/56 (14%)
		STKc_MLK1	137..406	CDD:271047	120/277 (43%)