DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wnd and LYN

DIOPT Version :9

Sequence 1:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_011515831.1	Gene:	LYN / 4067	HGNCID:	6735	Length:	682	Species:	Homo sapiens

Alignment Length:	290	Identity:	97/290 - (33%)
Similarity:	158/290 - (54%)	Gaps:	26/290 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 IEVKSQRSED---WQIPFESITELEWLGSGAQGAVFSGRLKNET-VAVKKVKE--------LKET 196
            |..|.|:..|   |:||.|||..::.||:|..|.|:.|...|.| ||||.:|.        |:|.
Human   397 ISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEA 461

  Fly   197 DIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQ---VMLPSRLVSWSKQIAL 258
            ::  ::.|.|:.:::...|.|:.....||.|:...|.|.:.||.::   |:|| :|:.:|.|||.
Human   462 NL--MKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLP-KLIDFSAQIAE 523

  Fly   259 GMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSR--EWNEISTKMSFAGTVAWMAPEVIRNE 321
            ||.|:.....|||||::.|:|:|.:.:.||:|||.:|  |.||.:.:......:.|.|||.|...
Human   524 GMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG 588

  Fly   322 PCSEKVDIWSYGVVLWEMLTC-EIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKS 385
            ..:.|.|:||:|::|:|::|. :|||....::.::..: :...::.....||:....::|:|||.
Human   589 CFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTAL-SQGYRMPRVENCPDELYDIMKMCWKE 652

  Fly   386 KPRNRPSFRQILSHLDIAGPELLRKTEKQY 415
            |...||:|..:.|.||    :....||.||
Human   653 KAEERPTFDYLQSVLD----DFYTATEGQY 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STYKc	161..400	CDD:214568	82/253 (32%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	83/250 (33%)
LYN	XP_011515831.1	SH3_Lyn	237..292	CDD:212937
		SH2_Src_Lyn	295..395	CDD:198227
		PTKc_Lyn	409..680	CDD:270657	93/278 (33%)
		Pkinase_Tyr	417..667	CDD:285015	82/253 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910