Protein Alignment wnd and map3k12

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_996977.2
• Gene: map3k12 / 404626
• ZFINID: ZDB-GENE-040426-2436
• Length: 897
• Species: Danio rerio
• Alignment Length: 958
• Identity: 364/958 - (37%)
• Similarity: 482/958 - (50%)
• Gaps: 216/958 - (22%)

  Fly    33 HGSSPNLSLDQTDNLRRSMACLQDEFGHLGIAATDLPFKSSDLDSPPRLQHHNNYAEITDSSAEN 97
            |.:||.|| |:..|...|:..|| |.|..|.|.      .|..|| .|||
Zfish    65 HSNSPTLS-DEPTNFSNSVLKLQ-EGGAEGGAV------RSQADS-FRLQ--------------- 105

  Fly    98 TCQQRWPPHVGGAGAAFGHPDKPIGWMYGLLGCMKPVLSFIGKTGVIEVKSQRSEDWQIPFESIT 162
                      .|.|          |::.||.||:|||.:.|||....|.|..:.|.|::|||.|:
Zfish   106 ----------PGGG----------GFLEGLFGCLKPVWTMIGKAYSTEHKQSQEECWEVPFEEIS 150

  Fly   163 ELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIME 227
            ||:|:|||||||||.|:...|.||||||:::|||:|||||||.|.|||.|||||||:|.:||:||
Zfish   151 ELQWVGSGAQGAVFLGKFHGEEVAVKKVRDIKETEIKHLRKLKHPNIITFKGVCTQAPCYCILME 215

  Fly   228 FCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFG 292
            :|..|.|..:|:..:.:.|..||.|:..||.||.|||.||||||||||||:||:.:::|||||||
Zfish   216 YCAQGQLYEVLRAGRKITPCLLVDWAMGIAGGMNYLHLHKIIHRDLKSPNMLITHDDLVKISDFG 280

  Fly   293 TSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWG 357
            ||:|..:.||||||||||||||||||||||.||||||||:|||||||||.|||||||||||||||
Zfish   281 TSKELRDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWEMLTGEIPYKDVDSSAIIWG 345

  Fly   358 VGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSHLDIAGPELLRKTEKQYFETQKSW 422
            ||||||:|.:|.:||:|||:|::.||..||||||||||||.|||||..::|...::.||::|..|
Zfish   346 VGNNSLQLPLPDSCPDGFKILLRQCWNCKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEW 410

  Fly   423 KEEVRSHLKEITQNGTNIHKYEQDLIKRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQ 487
            :|||:.|.::|...||.:|:.:::||.||..|.|||.|||..||.||::.|.|:.||:..|.||:
Zfish   411 REEVKQHFEKIKSEGTCLHRLDEELINRRREELRHALDIREHYERKLERANNLYMELNAVMLQLE 475

  Fly   488 EKEKEIAERE----RKLPGSGYKPNRRFGNTIRKMQHYRRRLNPAPAAIQQQSTTPDPETTPESP 548
            .||||:..||    :|.||. :|  ....||:.|:...|    .||..:......||
Zfish   476 LKEKELLRREQCLDKKYPGL-FK--HHTSNTVDKLIKKR----SAPQKLPPHGKRPD-------- 525

  Fly   549 VKCMLYAQLDSNCQPKS----YLANIIPSSGLGAPMPNKNKKV-FRHRRNASGSFG--APPKYSP 606
               :|.:::   ..||.    ....:.|.|..|:..|::.::| .||||...||.|  :.||
Zfish   526 ---LLRSEI---ILPKMDAGVLQVTVPPCSNRGSTSPSRARRVKTRHRRGGRGSSGDLSGPK--- 581

  Fly   607 TRDRRYQSEPENRKVQLVERQTQTDAMDVSETDISPSAEAPRSQPIDVPVPNHRQLPLQL----- 666
                 :.|.|.:|:.:.| ..|...|..::|   |.|....|...::.|       ||:|
Zfish   582 -----HPSAPASREREPV-ANTPPPAAPIAE---SVSGSTMREGQLEPP-------PLKLSSSSP 630

  Fly   667 ------QRVQK----IAQAQARARSGSTSSAAGAVNPACPSNGNSLSTSELTYQDACSSPDQLID 721
                  :||:.    :|..:...|.....:.|||.....|...::.|      :||.|.|.....
Zfish   631 DLLSSTRRVEDGVSGVATPETLGRDPRGGAEAGAGLDETPPRSDTAS------EDAASLPFSSSP 689

  Fly   722 DVMNSNERLDMTECCSDNENLERLGRKVIEFINENRLSIQSNTNSVSNADNGNGGASPLELRESG 786
            |          :.||..:   ..:||...|...|                  ..||..|....||
Zfish   690 D----------SPCCGRS---GAVGRPQAEEREE------------------GPGAVRLPRGSSG 723

  Fly   787 N----SPCLSRCSSTHSKRRKHPLGDNPNGSSIGNANGESHEQDSWSDEEGETTDYKYALRRRSI 847
            :    |..|.|.:.|..:||                 |.|.|     :|||| .|.:..|.||
Zfish   724 SHLTPSAILYRAAITRKQRR-----------------GVSSE-----EEEGE-VDSEVELPRR-- 763

  Fly   848 GRQPIARGMRPRRSYKAPLSQKIA-IHKRNVVIVSDEEENTSEYSHSPSSQHSTLESNTDIADMK 911
                       ||.......|.:: ....|:.:...||.:|:::|||.:.  ..:.:|||
Zfish   764 -----------RRPTSITKCQSVSTFSSENLSVSEGEEGHTTDHSHSGTP--DVVSTNTD----- 810

  Fly   912 KTQATSTSSNSYSEPEDDSSDSSDEEQGNR-------PTEAKAEGPAL 952
                         |..||.||.. ..||:.       ||.::.|..||
Zfish   811 -------------ERLDDRSDDL-ISQGSEIPVDITDPTLSEREAAAL 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	167/235 (71%)
map3k12	NP_996977.2	None