DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wnd and Raf

DIOPT Version :9

Sequence 1:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster

Alignment Length:	420	Identity:	113/420 - (26%)
Similarity:	186/420 - (44%)	Gaps:	64/420 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TAASRQQQQLHGRRRHHGSSPNLSLDQTDNLRRSMACLQDEFGHLGIAATDLPFKSSDLDSPPRL 81
            :::|:......|..| .|..|.:|.|...|...:: |:.:.     .:.|....:|..:.:.|.|
  Fly   317 SSSSKPPSSSSGNHR-QGRPPRISQDDRSNSAPNV-CINNI-----RSVTSEVQRSLIMQARPPL 374

  Fly    82 QH----HNNYAEITDSSAENTCQQRWPPHVGGAGAAFGHPDKPIGWMYGLLGCMKPVLSFIGKTG 142
            .|    |:|   .|.:|..:|.:.. .|....|..:                         .|..
  Fly   375 PHPCTDHSN---STQASPTSTLKHN-RPRARSADES-------------------------NKNL 410

  Fly   143 VIEVKSQRSEDWQIPFESITELEWLGSGAQGAVF----SGRLKNETVAVKKVKELK----ETDIK 199
            ::.......|:|.|..|.|.....:|||:.|.|:    .|.:..:|:.||.....:    :.::.
  Fly   411 LLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHWHGPVAVKTLNVKTPSPAQLQAFKNEVA 475

  Fly   200 HLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPL-QNILKEEQVMLPSRLVSWSKQIALGMQYL 263
            .|:|..|.||:.|.| |...|...|:.::|....| :::...|.....:.|:...:|:|.||.||
  Fly   476 MLKKTRHCNILLFMG-CVSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYL 539

  Fly   264 HSHKIIHRDLKSPNILISTNEVVKISDFG---TSREWNEISTKMSFAGTVAWMAPEVIRNE---P 322
            |:..||||||||.||.:..:..|||.|||   ....|:.........|::.||||||||.:   |
  Fly   540 HAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNP 604

  Fly   323 CSEKVDIWSYGVVLWEMLTCEIPYKDV-DSSAIIWGVGNNSLK---LLVPSTCPEGFKLLVKLCW 383
            .|.:.|::::|:|::|:|...:||..: :...|::.||...|:   ..|.|..|:..|.|.:.|.
  Fly   605 YSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCI 669

  Fly   384 KSKPRNRPSFRQILSHLDIAGPELLRKTEK 413
            |..|::||.||.:|:.|:    .:||...|
  Fly   670 KYTPKDRPLFRPLLNMLE----NMLRTLPK 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STYKc	161..400	CDD:214568	83/257 (32%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	83/254 (33%)
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514
		C1_Raf	221..269	CDD:410361
		STKc_Raf	435..687	CDD:270964	82/252 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445235
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840