DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wnd and Map3k13

DIOPT Version :9

Sequence 1:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001014000.2	Gene:	Map3k13 / 303823	RGDID:	1561227	Length:	958	Species:	Rattus norvegicus

Alignment Length:	1045	Identity:	375/1045 - (35%)
Similarity:	496/1045 - (47%)	Gaps:	275/1045 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GSSPNLSLDQTDNLRRSMACLQDEFGHLGIAATDLPFKSSDLDS---PPRLQHHNNY-------- 87
            |:.|:....: |:..|.:| :|.|...:    |..|..::.|.|   ..|.|..|:.
  Rat    34 GNHPSPKFPE-DSQERVVA-IQSELTEI----TGSPVSTTVLTSVSEDSRSQFENSVLQLREQDE 92

  Fly    88 AEITDS-------SAENTCQQRWPPHV------GGAGAAFGHPDKPIGWMYGLLGCMKPVLSFIG 139
            :|:|.|       ..|||   ..|..:      .|:|:.        |::.||.||::||.:.||
  Rat    93 SEVTVSPGNSNTVDGENT---NGPEDIKIQFSRSGSGSG--------GFLEGLFGCLRPVWNIIG 146

  Fly   140 KTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDIKHLRKL 204
            |....:.|.|:.:.|::|||.|:||:|||||||||||.|:.:.|.||:|||:|..||||||||||
  Rat   147 KAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKL 211

  Fly   205 DHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSHKII 269
            .|.|||.|||||||:|.:|||||:|.:|.|..:|:..:.:.|..||.||..||.||.|||.||||
  Rat   212 KHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKII 276

  Fly   270 HRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGV 334
            ||||||||:|::..:.|||||||||:|.::.||||||||||||||||||||||.||||||||:||
  Rat   277 HRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGV 341

  Fly   335 VLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSH 399
            ||||:||.|||||||||||||||||:|||.|.||||||:|||:|:|..|:|||||||||||.|.|
  Rat   342 VLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH 406

  Fly   400 LDIAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTNIHKYEQDLIKRRTAEWRHAQDIRMV 464
            ||||..::|...::.||::|..|:|||:.|.::|...||.||:.:::||:||..|.|||.|||..
  Rat   407 LDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREH 471

  Fly   465 YEDKLQKTNQLFFELSECMSQLQEKEKEIAER----ERKLPGSGYK--PNRRF--GNTIRKMQHY 521
            ||.||::.|.|:.|||..|.||:.:|||:.:|    |:|.||: ||  |.|..  .|.:.|:.
  Rat   472 YERKLERANNLYMELSAIMLQLEMREKELLKREQAVEKKYPGT-YKRHPVRPIIHPNAMEKLM-- 533

  Fly   522 RRRLNPAPAAIQ-------QQSTTPDPETTP-ESPVKCMLYAQLDSNCQPKSYLANIIPSSGLGA 578
            :|::....|.:|       :....|..|..| .||:...                   |....|:
  Rat   534 KRKVVSHKAGVQTKRPDLLRSEGIPSTEAVPTASPLSGS-------------------PKMSTGS 579

  Fly   579 PMPNKNKKVFRHRR-NASGS---FGAPPKYSPTRDRRYQSEPENRKVQLVERQTQTDAMDVSETD 639
            .......|. |||| |:.||   |.|..|..|.:    ::.|....:|..:.|
  Rat   580 SRSRYRSKP-RHRRGNSRGSHSDFAAILKTQPAQ----ENSPHPTYLQHTQAQ------------ 627

  Fly   640 ISPSA---EAPRSQPIDVPVPNHRQLPLQLQRVQKIAQAQARARSGSTSSAAGAVNPACPSNGNS 701
             .|||   ..|:.| :..|:|..|. |......|.||......|....::|.           .|
  Rat   628 -CPSAYQHNLPQQQ-VPPPLPQSRH-PRLNAHGQDIATCANNLRYFGPAAAL-----------RS 678

  Fly   702 LSTSELTYQDACSSPDQLIDDVMNS----NERLDMTE-----CCSDNENLERLGRKVIEFINENR 757
            ..::....|...|||| ||...|.:    |..||..:     ||.
  Rat   679 PLSNHAQRQMPGSSPD-LISTAMAADCWRNSELDQDQVGPWGCCQ-------------------- 722

  Fly   758 LSIQSNTNSVSNADNGNGGASPLELRESGNSPCLSRCSSTHSKR----RKHPLGDNPNGSS---- 814
                               |.|.:       ||. :|...||..    ...|:|.:|:.||
  Rat   723 -------------------AEPYD-------PCF-QCRPEHSGSLDVPTTEPVGRSPDPSSSPAH 760

  Fly   815 ---IGNANGE---------------SHE----------------QDSWSDEEGETTDYKYALRRR 845
               .|||.|.               ||:                .|..|:|||| .|.:....||
  Rat   761 NPLSGNAQGSERTEANGFNGCQSGISHQFTPPLLPQKPRPLQKSGDDSSEEEGE-VDSEVEFPRR 824

  Fly   846 SIGRQPIARGMRPRR------SYKAPLSQKIAIHKRNVVIVSD-EEENTSEYSHSPS-------- 895
                      .||.|      ||....|:..:        ||| ||.|||::|:||.
  Rat   825 ----------QRPHRCISSYQSYSTFSSENFS--------VSDGEEGNTSDHSNSPDESANRRQD 871

  Fly   896 --------------------SQHSTLESNTDIADMK-KTQAT----STSSNSYSEPEDDSSDSSD 935
                                |.||...|:.:.|..: |||.:    ......|..|...:....|
  Rat   872 RLAETLDDLLSQTPEAPIEISSHSDGLSDKECAVRRVKTQMSLGKLCAEERGYENPVQFADSDRD 936

  Fly   936 EEQGN 940
            ..:|:
  Rat   937 SSEGD 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STYKc	161..400	CDD:214568	171/238 (72%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	170/235 (72%)
Map3k13	NP_001014000.2	STYKc	168..402	CDD:214568	168/233 (72%)
Map3k13	NP_001014000.2	STKc_MAP3K12_13	174..410	CDD:270961	170/235 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	356	1.000	Domainoid score	I952
eggNOG	1	0.900	-	-		E1_KOG4721
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	504	1.000	Inparanoid score	I1295
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003049
OrthoInspector	1	1.000	-	-		otm44868
orthoMCL	1	0.900	-	-		OOG6_105153
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.720