DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wnd and Map3k21

DIOPT Version :10

Sequence 1:NP_649137.3 Gene:wnd / 40143 FlyBaseID:FBgn0036896 Length:977 Species:Drosophila melanogaster
Sequence 2:NP_663583.2 Gene:Map3k21 / 234878 MGIID:2385307 Length:1002 Species:Mus musculus


Alignment Length:1004 Identity:244/1004 - (24%)
Similarity:354/1004 - (35%) Gaps:356/1004 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 IPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETD----IKHLRK-------LDHENI 209
            :.||.:...|.:|:|..|.|:....:.:.||||..:...|.|    .:.:|:       |.|.||
Mouse   105 VDFERLELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARLFAMLRHPNI 169

  Fly   210 IKFKGVCTQSPVFCIIMEFCPYGPLQNIL------------KEEQVMLPSRLVSWSKQIALGMQY 262
            |:.:|||.:.|..|:::||...|.|...|            :..:.:.|..||:|:.|||.||.|
Mouse   170 IQLRGVCLRQPHLCLVLEFARGGALNRALAAAASDPRAPGPRRARRIPPQVLVNWAVQIARGMLY 234

  Fly   263 LHSH---KIIHRDLKSPNILI--------STNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPE 316
            ||..   .|:||||||.|||:        ..|:.:||:|||.:|||:. :|:||.|||.||||||
Mouse   235 LHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHR-TTRMSAAGTYAWMAPE 298

  Fly   317 VIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKL 381
            |||:...|:..|||||||:|||:||.|:||:.:|..|:.:||..|.|.|.:||||||.|..|:|.
Mouse   299 VIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKE 363

  Fly   382 CWKSKPRNRPSFRQILSHLDIAGPELLRKTEKQYFET-QKSWKEEVRSHLKEITQNGTNIHKYEQ 445
            ||:..|..||||..||..|......:|....::.|.: |:.||.|::....|:......:...|:
Mouse   364 CWEQDPHIRPSFALILQQLTAIEEAVLTNMPQESFHSMQEDWKLEIQQMFSELRTKEKELRSREE 428

  Fly   446 DLIKRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAERERKLPGSGYKPNRR 510
            :|.:....                ||:.:|.         |:.:|:::||||             
Mouse   429 ELSRAALQ----------------QKSQELL---------LRRREQQLAERE------------- 455

  Fly   511 FGNTIRKMQHYRRRLNPAPAAIQQQSTTPDPETTPESPVKCMLYAQLDSNCQPKSYLANIIPSSG 575
                   :....|.||                         :|..||...               
Mouse   456 -------IDVLERELN-------------------------VLIFQLSQE--------------- 473

  Fly   576 LGAPMPNKNKKVFR---------HRRNASGSF--GAPPKYSPTRDRRYQSE-------------P 616
              ||...|.|..||         ||.:....|  ....:.|||.|:|..|:             |
Mouse   474 --APHVKKRKGRFRRGRLRLKDGHRISLPSDFQHKITVQASPTLDKRRSSDSGLCSPPGSPLMLP 536

  Fly   617 ENRKVQLVERQT-----------QTDAMDVSET------DISPSAEAPRSQPIDVPVPNHRQLPL 664
            ..|.:||...:.           |.|..||..:      ...||:...:.:|             
Mouse   537 RLRAIQLTSDENNKTRGRNMVFRQEDFEDVKRSFKKKGCTWGPSSVQTKERP------------- 588

  Fly   665 QLQRVQKIAQAQARARSGSTSSAAGAVNPACPSNGNSLSTSELTYQDACSSPDQLIDDVMNSNER 729
                       :.|.|          |.|.  |:|||..:|.|......:....|..|...|.|.
Mouse   589 -----------EGRER----------VRPL--SDGNSPWSSLLIKSQKTTPLASLFVDQPGSCEE 630

  Fly   730 LDMTECCSDNENLERLGRKVIEFINENRLSI-------QSNTNSVSNADNGNGGASP-------- 779
            ..:..     |.||....|..:|..:..:.:       :.:::...:.:.|:...||        
Mouse   631 QKLVP-----EGLEHRKPKQTKFPGQAHVGLPLCKDSQREDSSEAESREEGSPKGSPVNNVGAPM 690

  Fly   780 ----------------------------------------LELRESGNSPCLSRCSSTHSKRRKH 804
                                                    :|.:|.|.....|||.|:.|...:.
Mouse   691 LRKKTESALCECGMLLASMALGLDVRKLHGAQAPAKPSPKMEKKEEGALQPASRCQSSPSSLLRQ 755

  Fly   805 P-LGDNPNG------------------------------SSIGNANGESHEQDSWSDEEGETT-- 836
            | .|..|:|                              ||:|||.          |..|.||  
Mouse   756 PSAGRAPSGGSTLLLPSAPSHSSKSSLSMKCLLQAGKEESSLGNAR----------DLCGPTTLT 810

  Fly   837 -DYKYALRRRSIGRQPIARGMRPRRSYKAPLSQKIAIHKR------NVVIVSDEEENTSEYSHSP 894
             |...|.........|   |:||:..|....|...||.::      ...||.|:           
Mouse   811 PDPGSAAPESGCELIP---GLRPKTDYGVLRSMPHAILEQTGERLPGCAIVGDK----------- 861

  Fly   895 SSQHSTLESNTDIADMKKTQATSTSSNSYSEPEDDS-----SDSSDEEQGNRPTEAKAEG----- 949
            ...|..:.|.            .|.....|.|||..     |.....:..::.:..|.||     
Mouse   862 GCHHMQMGSE------------ETPLWLQSAPEDSGLPHSPSPGPQRDLASQASLVKPEGVLGEC 914

  Fly   950 ---PALPM----GAVRSSDIISIPTFEAD 971
               ||||.    .:||::   |.||:..|
Mouse   915 QACPALPQRPHTASVRTT---SPPTWVCD 940

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wndNP_649137.3 STKc_MAP3K12_13 167..403 CDD:270961 114/269 (42%)
Map3k21NP_663583.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
SH3 28..82 CDD:473055
Protein Kinases, catalytic domain 115..385 CDD:473864 114/270 (42%)
Leucine-zipper 1 409..430 2/20 (10%)
Leucine-zipper 2 444..466 9/66 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 508..531 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..604 11/65 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 640..689 5/48 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 721..778 12/56 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 797..823 9/35 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 878..899 5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

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