DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wnd and FGR

DIOPT Version :9

Sequence 1:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001036194.1	Gene:	FGR / 2268	HGNCID:	3697	Length:	529	Species:	Homo sapiens

Alignment Length:	304	Identity:	89/304 - (29%)
Similarity:	143/304 - (47%)	Gaps:	43/304 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 MKPVLSFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNET-VAVKKVKE-- 192
            |||....:.|           :.|:|...|||....||:|..|.|:.|.....| ||||.:|.
Human   244 MKPQTLGLAK-----------DAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297

  Fly   193 ------LKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKE---EQVMLPSR 248
                  |:|..:  ::.|.|:.:::...|.::.|:: |:.||..:|.|.:.||.   :.:.|| :
Human   298 MSPKAFLEEAQV--MKLLRHDKLVQLYAVVSEEPIY-IVTEFMCHGSLLDFLKNPEGQDLRLP-Q 358

  Fly   249 LVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSR-----EWNEI-STKMSFA 307
            ||..:.|:|.||.|:.....|||||::.|||:......||:|||.:|     |:|.. .:|.
Human   359 LVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF--- 420

  Fly   308 GTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLT-CEIPYKDVDSSAIIWGVGNNSLKLLVPSTC 371
             .:.|.|||.......:.|.|:||:|::|.|::| ..|||..::...::..| .....:..|..|
Human   421 -PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQV-EQGYHMPCPPGC 483

  Fly   372 PEGFKLLVKLCWKSKPRNRPSFRQILSHLDIAGPELLRKTEKQY 415
            |......::..|:..|..||:|..:.|.|:    :.....|.||
Human   484 PASLYEAMEQTWRLDPEERPTFEYLQSFLE----DYFTSAEPQY 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STYKc	161..400	CDD:214568	78/257 (30%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	77/254 (30%)
FGR	NP_001036194.1	SH3	80..137	CDD:327375
		SH2_Src_Fgr	140..240	CDD:198230
		PKc_like	267..514	CDD:328722	77/259 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910