Protein Alignment wnd and FGFR1

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_001167538.1
• Gene: FGFR1 / 2260
• HGNCID: 3688
• Length: 853
• Species: Homo sapiens
• Alignment Length: 366
• Identity: 111/366 - (30%)
• Similarity: 169/366 - (46%)
• Gaps: 91/366 - (24%)

  Fly   133 PVLSFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVF----SGRLKNE-----TVAVK 188
            |:|:     ||.|.:......|::|.:.:...:.||.|..|.|.    .|..|::     .||||
Human   486 PMLA-----GVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVK 545

  Fly   189 KVK-ELKETDIKHL------RKL--DHENIIKFKGVCTQ-SPVFCII------------------ 225
            .:| :..|.|:..|      .|:  .|:|||...|.||| .|::.|:
Human   546 MLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP 610

  Fly   226 -MEFCPYGPLQNILKEEQVMLPSR-LVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKI 288
             :|:| |.|..|  .|||  |.|: |||.:.|:|.||:||.|.|.|||||.:.|:|::.:.|:||
Human   611 GLEYC-YNPSHN--PEEQ--LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 670

  Fly   289 SDFGTSREWNEIS-TKMSFAG--TVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLTC-EIPYKDV 349
            :|||.:|:.:.|. .|.:..|  .|.|||||.:.:...:.:.|:||:||:|||:.|. ..||..|
Human   671 ADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV 735

  Fly   350 DSSAIIWGVGNNSLKLL-------VPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSHLDIAGPEL 407
            ....:        .|||       .||.|.....::::.||.:.|..||:|:|::..||    .:
Human   736 PVEEL--------FKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD----RI 788

  Fly   408 LRKTEKQYF-------------------ETQKSWKEEVRSH 429
            :..|..|.:                   .|..|.::.|.||
Human   789 VALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSH 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	97/285 (34%)
FGFR1	NP_001167538.1	IgI_1_FGFR	58..151	CDD:409362
		Ig strand A	58..61	CDD:409362
		Ig strand A'	73..79	CDD:409362
		Ig strand B	82..92	CDD:409362
		Ig strand C	96..101	CDD:409362
		Ig strand C'	104..106	CDD:409362
		Ig strand D	111..115	CDD:409362
		Ig strand E	118..123	CDD:409362
		Ig strand F	129..138	CDD:409362
		Ig strand G	141..151	CDD:409362
		IgI_2_FGFR	184..278	CDD:409443
		Ig strand A	184..187	CDD:409443
		Ig strand A'	195..200	CDD:409443
		Ig strand B	204..212	CDD:409443
		Ig strand C	218..223	CDD:409443
		Ig strand C'	226..228	CDD:409443
		Ig strand D	237..240	CDD:409443
		Ig strand E	244..249	CDD:409443
		Ig strand F	258..265	CDD:409443
		Ig strand G	268..278	CDD:409443
		Ig	286..390	CDD:472250
		Ig strand B	304..308	CDD:409353
		Ig strand C	317..321	CDD:409353
		Ig strand E	355..359	CDD:409353
		Ig strand F	369..374	CDD:409353
		Ig strand G	382..385	CDD:409353
		PTKc_FGFR1	495..796	CDD:270678	100/317 (32%)