Protein Alignment wnd and Ripk1

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_033094.3
• Gene: Ripk1 / 19766
• MGIID: 108212
• Length: 656
• Species: Mus musculus
• Alignment Length: 654
• Identity: 145/654 - (22%)
• Similarity: 251/654 - (38%)
• Gaps: 175/654 - (26%)

  Fly   185 VAVKKV---------KELKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKE 240
            |.:|||         .|:...:.|.:.:|.|..::|..|:..:...:.::||:...|.|.::||.
Mouse    42 VILKKVYTGPNRAEYNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKT 106

  Fly   241 E---QVMLPSRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTS--REWNEI 300
            :   .:.|..|::   .:...||.|||...:||:|||..|||:..:..:||:|.|.:  :.|:::
Mouse   107 QIDVPLSLKGRII---VEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKL 168

  Fly   301 -------------STKMSFAGTVAWMAPEVIR--NEPCSEKVDIWSYGVVLWEMLTCEIPYKDV- 349
                         :||.:..||:.:||||.:.  |...:||.|::|:|:|||.:...:.||::|
Mouse   169 TKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVI 233

  Fly   350 --DSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQI--------LSHLDIAG 404
              :...|....||......:...||.....|::.||::.|.:||:|..|        |||.:...
Mouse   234 CTEQFVICIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYV 298

  Fly   405 PELLRKTEKQY----------FETQ---------KSWKEEVRS-HLKEITQNG-------TNIHK 442
            .|.:...:|:|          |..|         :|..|:..| |..:..|.|       ::..:
Mouse   299 EEDVASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSSSPE 363

  Fly   443 YEQDLIKRRTAEWRHAQDIRMVYEDKLQK--TNQLFFELSECMSQLQEKEKEI--AERERKLPGS 503
            |.||            ::.|.| :.|||:  :...|...:|..::.|.::.|.  .|.|||
Mouse   364 YPQD------------ENDRSV-QAKLQEEASYHAFGIFAEKQTKPQPRQNEAYNREEERK---- 411

  Fly   504 GYKPNRRFGNTIRKMQH-----YRRRLNPAPAAIQQQSTTPDPETTPESPVKCMLYAQLDSNCQP 563
                        |::.|     .|.|.|...|..:..|   ||.||.....           .|.
Mouse   412 ------------RRVSHDPFAQQRARENIKSAGARGHS---DPSTTSRGIA-----------VQQ 450

  Fly   564 KSYLA-NIIPSSGLGAPMPNKNKKVFRHRRNASGSFGAPPKYSPTRDRRYQSEPENRKVQLVERQ 627
            .|:.| ..:.::||             :.::..|:.|....|.|...:.|
Mouse   451 LSWPATQTVWNNGL-------------YNQHGFGTTGTGVWYPPNLSQMY--------------- 487

  Fly   628 TQTDAMDVSETDISPSAEAPRSQPIDVPVPNHRQLPLQLQRVQKIAQAQARARSGSTSSAAGAVN 692
             .|....|.||:|          |...|...:...|:....::......:..:.|:.:.....:|
Mouse   488 -STYKTPVPETNI----------PGSTPTMPYFSGPVADDLIKYTIFNSSGIQIGNHNYMDVGLN 541

  Fly   693 PACPSN---GNSLSTSELTYQDACSSPDQLIDDV--------MNSNERLDMTECCSD--NENLER 744
            ...|:|   ..|.|..:..:.:..|..|:.::.:        .|...:|..||...|  :.:.||
Mouse   542 SQPPNNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLGRQWKNCARKLGFTESQIDEIDHDYER 606

  Fly   745 LGRK 748
            .|.|
Mouse   607 DGLK 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	72/257 (28%)
Ripk1	NP_033094.3	Protein Kinases, catalytic domain	23..291	CDD:473864	69/251 (27%)
		Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:Q13546	291..567		65/357 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..373		10/57 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..423		9/50 (18%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:18442983, ECO:0000269|PubMed:27819681, ECO:0000269|PubMed:27819682	520..536		1/15 (7%)
		Death_RIP1	568..653	CDD:260048	10/43 (23%)