Protein Alignment wnd and MLKL

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_689862.1
• Gene: MLKL / 197259
• HGNCID: 26617
• Length: 471
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 75/287 - (26%)
• Similarity: 130/287 - (45%)
• Gaps: 48/287 - (16%)

  Fly   155 QIPFESITELE--------W--LGSGAQGAVFSGRLKNETVAVKKVKELK-----------ETDI 198
            :||.|.|.|::        |  |.......::.|......||:|..|:|:           ..:|
Human   187 EIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEI 251

  Fly   199 KHLRKLDHENIIKFKGVCTQS----PVFCIIMEFCPYGPLQNIL-KEEQVMLPSRLVSWSKQIAL 258
            |.::|.:..||::..|:|...    |.|.|:||:|..|.|:.:| :|:.:.|..|:| .....|.
Human   252 KTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMV-LVLGAAR 315

  Fly   259 GMQYLHSHKI--IHRDLKSPNILISTNEVVKISDF-----------GTSREWNEISTKMSFAGTV 310
            |:..||..:.  :|..::|.|.|::....||::.|           ||:||      |.....:.
Human   316 GLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTRE------KTDRVKST 374

  Fly   311 AWMAPEVIRN--EPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPE 373
            |:::|:.:.:  .....|.:|:|:|:||||:.|.:||::..:|..|...|.....:..:...||.
Human   375 AYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPS 439

  Fly   374 GFKLLVKLCWKSKPRNRPSFRQILSHL 400
            ..:.::..|....|..|||..:||..|
Human   440 ELREIIDECRAHDPSVRPSVDEILKKL 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	69/265 (26%)
MLKL	NP_689862.1	N-terminal bundle and brace (NBB), mediates INSP6 binding. /evidence=ECO:0000269|PubMed:29883610	1..149
		MLKL_NTD	5..121	CDD:411030
		Protein Kinases, catalytic domain	177..469	CDD:473864	75/287 (26%)