Protein Alignment wnd and zak-1

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_001367790.1
• Gene: zak-1 / 175954
• WormBaseID: WBGene00006971
• Length: 745
• Species: Caenorhabditis elegans
• Alignment Length: 886
• Identity: 212/886 - (23%)
• Similarity: 341/886 - (38%)
• Gaps: 267/886 - (30%)

  Fly   148 SQRSEDWQIPF-----ESITELEWLGSGAQGAVFSGRL-----KNETVAVKKVKEL-KETDIKHL 201
            |..:.|.::.|     :.|...:.:|.|..||||||..     ...|:|:|||..| ||.:|  |
 Worm    13 SSNNSDQRVLFPDIQRDDIQVGDHIGVGTFGAVFSGNWTLPDGSQRTIALKKVFVLEKEAEI--L 75

  Fly   202 RKLDHENIIKFKGVC-TQSPVFCIIMEFCPYGPLQNIL--KEEQVMLPSR-------LVSWSKQI 256
            .|:.|:|||:|.|:| .....|.|:.|:...|.|.:.:  :|.|....|.       :|.|:.||
 Worm    76 SKIRHKNIIQFYGICKATGNDFFIVTEYAEKGSLYDFIHSEESQSFASSSGGNSFDVVVKWASQI 140

  Fly   257 ALGMQYLH---SHKIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPE-V 317
            |.|:||||   ...||||||||.|:::..|.|.||.|||||::.....|..|:.||.|||:|| :
 Worm   141 ASGIQYLHYDAVDTIIHRDLKSKNVVLDKNLVCKICDFGTSKDLTHSCTAPSWGGTAAWMSPEMI 205

  Fly   318 IRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLC 382
            :::|..:...|:|||||||||:|:.|:||||.....|...:..:.:.|.:|.:||...|.|:..|
 Worm   206 LQSEGLTTATDVWSYGVVLWEILSKEVPYKDYSEFRIFTMITQSGITLAIPPSCPAPLKQLMSNC 270

  Fly   383 WKSKPRNRPSFRQILSHLD-IAG-PELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTNIHKYEQ 445
            ||..|::|.:.|||...|: :|| .:::.:.||  |...:.||.|:....|       |:.|..:
 Worm   271 WKMTPKDRANMRQIQGELNRLAGNQKVMDECEK--FMGLEDWKTEIEKQEK-------NVEKMRK 326

  Fly   446 DLIKRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAER---ERKLPGSGYKP 507
            ||.|||                                .||:.:||.:.:|   |:.:..|...|
 Worm   327 DLEKRR--------------------------------EQLEIREKALKQRMKVEQAVLDSARHP 359

  Fly   508 NRRFGNTIRKMQHYRRRLNPAPAAIQQQS---TTPDPETTPESPVKCMLYAQLDSNCQPKSYLAN 569
                                 |..:.|.|   |:...||.            |......|.:|..
 Worm   360 ---------------------PEDVHQWSEHHTSHWVETV------------LGRVANDKKFLDR 391

  Fly   570 IIPSSGLGAPMPNKNKKVFRHRRNASGSFGAPPKYSPTRDRRYQSEPENRKVQLVERQTQTDAM- 633
            :             |..|||:|...:...|..           |::.|:..|..|..:.:...|
 Worm   392 V-------------NAAVFRNRITGARLLGMT-----------QNDLEHLGVHKVGSRIELMKMI 432

  Fly   634 -DVSETDIS----PSAEAPRSQPIDVPVPNHRQLPLQLQR-----------VQKI---------- 672
             .:::|..:    |:.|  :::.|::.:...::...||..           |:|:
 Worm   433 RKLADTQKALHNFPTLE--QAKRIEMTLKTEKEAAGQLANDVDIVIIVGMYVRKMNATRRKFKFY 495

  Fly   673 --------AQAQARARSGSTSSAAGAV--------------NPACPSNGNSLSTSELTYQDACSS 715
                    ....|:::|...||....|              .|||     |:|:...|      :
 Worm   496 ADSDWIDDTDIPAKSKSKHASSLIKTVCFSVLDENTKKPINEPAC-----SISSGMTT------N 549

  Fly   716 PDQLI----DDV-MNSNERLDMTECCSDNENLERLGRKVIEFINENRLSIQSNTNSVSNADNGNG 775
            ||.:.    ||| :.....:...:..:...|.|.:  ||:..:.|:::..:.:.:
 Worm   550 PDWITVDTEDDVKIRVIVSVYYADIVTQPRNTEVI--KVVTSLEESKILEERHVH---------- 602

  Fly   776 GASPLELRESGNSPCLSRCSSTHSKRRKHPLGDNPNG----SSIGNANGESHEQDSWSDEEGETT 836
                |.||.|.:|..:|..|...:. ..||.|...||    :|.....|..|.:.:..:..|
 Worm   603 ----LRLRRSSSSASISTPSPVIAP-VYHPFGHLNNGFHHTTSSPQLRGFWHRKQTGMNRHG--- 659

  Fly   837 DYKYALRRRSIGRQPIARGMRPRRSYKAPLSQKIAIHKRNVVIVSDEEENTSEYSHSPSSQHSTL 901
                                                      :...|..:..|...:||.....:
 Worm   660 ------------------------------------------LTETELSSLQEQLRTPSPDKKVV 682

  Fly   902 ESNTDIADMKKT-QATSTSSNSYSEPEDDSSDSSDEEQGNR 941
            :.|..|...|.| :..:|::||....:.|:::.:.|.|..|
 Worm   683 DENVIIHVPKLTRRRRTTTTNSEDTEKSDTNNKTPESQARR 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	104/256 (41%)
zak-1	NP_001367790.1	Protein Kinases, catalytic domain	38..291	CDD:473864	104/254 (41%)