DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wnd and sel-15

DIOPT Version :9

Sequence 1:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001366799.1	Gene:	sel-15 / 175225	WormBaseID:	WBGene00016030	Length:	847	Species:	Caenorhabditis elegans

Alignment Length:	344	Identity:	100/344 - (29%)
Similarity:	160/344 - (46%)	Gaps:	54/344 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 KTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKEL-----KETD-- 197
            |..:::::|.....:.:....|...|.:|||:.|.|:.|..:.:.||||:.:.:     .|||
Worm   495 KADLLQLRSALPAPFHLCLAEIEFQESIGSGSFGKVYKGTYRGKLVAVKRYRAMAFGCKSETDML 559

  Fly   198 ---IKHLRKLDHENIIKFKGVCTQSP-VFCIIMEFCPYGPLQNILKEE-QVMLPSRLVSWSKQIA 257
               :..|.:|.|.|::.|.|.....| .|.||.||...|.|..:|.|| :||.|:..:..|..:|
Worm   560 CREVSILSRLAHPNVVAFVGTSLDDPSQFAIITEFVENGSLFRLLHEEKRVMDPAFRLRISLDVA 624

  Fly   258 LGMQYLH---SHKIIHRDLKSPNILISTNEVVKISDFGTSR----EWNEISTKMSFAGTVAWMAP 315
            .||:|||   :..:|||||.|.||||..:....::|||.||    ..:|..||.  .|.:.||||
Worm   625 RGMRYLHESAAKPVIHRDLNSHNILIHADGRSVVADFGESRFVCQREDENLTKQ--PGNLRWMAP 687

  Fly   316 EVI-RNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSA----IIWGVGNNSLKLLVPSTCPEGF 375
            ||. ::.....|||::|:.:|:||:.|.|:|:..:..:|    :.:..|..:|.....:..|...
Worm   688 EVFSQSGKYDRKVDVFSFALVIWEIHTAELPFSHLKPAAAAAEMTYKRGRPTLPNQPTAQFPAHI 752

  Fly   376 KLLVKLCWKSKPRNRPSFRQIL---------SHLDIAGPELLRKTEKQYFETQKSWKE------- 424
            ..|:...|..:..:||.|.:|:         :|.||:.|..:.:...|       |::
Worm   753 LSLIPQAWHPESSSRPDFVEIVALLEPHVESTHTDISAPSTVSQLTSQ-------WEQLSVAPPP 810

  Fly   425 -----EVRSHLKEITQNGT 438
                 .:.|.|..|...||
Worm   811 ASKFPPILSALHGIAATGT 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STYKc	161..400	CDD:214568	87/271 (32%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	87/268 (32%)
sel-15	NP_001366799.1	ANKYR	3..217	CDD:223738
		ANK repeat	115..147	CDD:293786
		PHA03095	128..>388	CDD:222980
		ANK repeat	153..180	CDD:293786
		ANK repeat	182..213	CDD:293786
		ANK repeat	215..246	CDD:293786
		ANK repeat	285..318	CDD:293786
		ANK repeat	320..353	CDD:293786
		ANKYR	<323..458	CDD:223738
		ANK repeat	355..380	CDD:293786
		PKc_TNNI3K	522..780	CDD:270966	85/259 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910