DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wnd and dlk-1

DIOPT Version :9

Sequence 1:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001021443.1	Gene:	dlk-1 / 173128	WormBaseID:	WBGene00001008	Length:	928	Species:	Caenorhabditis elegans

Alignment Length:	1071	Identity:	309/1071 - (28%)
Similarity:	453/1071 - (42%)	Gaps:	293/1071 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DLVTAASRQQQQLHGRRRHHGSSPNLSLDQTDNLRRSMACLQDEFGHLGIAATDLPFKSSDLD-- 76
            ||||..|.:|.         |.:|                                 :|||..
Worm    11 DLVTPTSEEQP---------GPAP---------------------------------ESSDFSTV 33

  Fly    77 --SPPRLQHHNNYAEITDSSAENT------------CQQRWPPHVGGAGAAFGHPDKP------- 120
              ||       :.:|:...||.||            .|:...|......||.|:..||
Worm    34 VLSP-------DGSELVTQSAPNTPIQHREQANAEFGQKEGSPDPKNMVAATGNASKPSLNSFYA 91

  Fly   121 --IGWM-YGLLGCMKPVLSFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKN 182
              :|.: .||..|.:||..:.|....:|::....|.|:|||::|:||||||||:|||||.|:|:|
Worm    92 DGLGQLRNGLFSCFQPVFGYFGTKTTVEIEKSEDELWEIPFDAISELEWLGSGSQGAVFRGQLEN 156

  Fly   183 ETVAVKKVKELKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPS 247
            .|||||||.:||||:|||||.|.|:|||:|.|||::||.:||:||:|..|.|..:||....:...
Worm   157 RTVAVKKVNQLKETEIKHLRHLRHQNIIEFLGVCSKSPCYCIVMEYCSKGQLCTVLKSRNTITRE 221

  Fly   248 RLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREWNEI-STKMSFAGTVA 311
            ....|.|:||.||.|||.:|:|||||||||||||..:.:||.|||||....:: ||.|||.|||:
Worm   222 LFAQWVKEIADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHMQKKMDSTMMSFCGTVS 286

  Fly   312 WMAPEVIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFK 376
            |||||:|:.:||:||||::|:|||||||||.|.||.::...|||:|||.|.|.|.:|...|:|..
Worm   287 WMAPEMIKKQPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVGTNILSLPMPEEAPKGLV 351

  Fly   377 LLVKLCWKSKPRNRPSFRQILSHLDIAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQNGT--- 438
            ||:|.|...|.||||||..|..|.:|..|||...||:::   |.:| :..|...|.|....|
Worm   352 LLIKQCLSQKGRNRPSFSHIRQHWEIFKPELFEMTEEEW---QLAW-DSYREFAKCIQYPSTVTR 412

  Fly   439 ------NIHKYEQDLIKRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAERE 497
                  :....|:::.::|..:..|.:|||.:||.||::||:::.:|..|.::|:.||.|:||.|
Worm   413 DHGGPKSAFAMEEEIQRKRHEQLNHIKDIRNMYEMKLKRTNKMYDKLQGCFTELKLKESELAEWE 477

  Fly   498 RKLPGSGYKPNRRFGNTIRKMQHYRRRLNPAP-AAIQQQSTTPDPETTPESPVKCMLYAQLDSNC 561
            :.|.......|:   |:.:.:...|.:|...| ......|:..|.:....||.:|
Worm   478 KDLTEREQWHNQ---NSPKAVAAPRAQLRGYPNEGYDDMSSDEDVQPCRGSPYRC---------- 529

  Fly   562 QPKSYLANIIPSSGL-GAPMPNKNKKVFRHRRNASG-----SFGA-PPKY--------------- 604
                  :|...|||: .:|...::..     |:::|     |.|| |||.
Worm   530 ------SNTSSSSGVQSSPFSRQSSS-----RSSAGQQTRRSEGANPPKILRNDAIRHSGSYWET 583

  Fly   605 ------SPTRDRRYQSEP-------------ENRKVQLVERQT--------QTDAMDVSETDISP 642
                  ||.||..:..:.             .....|:...||        .:|....|...:|.
Worm   584 LGGARGSPARDSGFSQDSGMWSAGAGSCTAINGGGQQVCYSQTLYRNGDGRWSDGRIASRRRVST 648

  Fly   643 SAEAPRSQPIDVPVPNHRQLPLQLQRVQKIAQAQARARSGSTSSAAGAVNPACPSNGNSLSTSEL 707
            |.....:.| ..||...|..|.::..                    |.::.:.|.:.:.|:.|..
Worm   649 SVNKSTAVP-GQPVFFTRDSPSRVPH--------------------GVISCSSPRSSSKLNRSSY 692

  Fly   708 TYQDACSSPDQLIDDVMNSNERLDMTECCSDNENLERLGRKVIEFINENRLSIQSNTNSVSNADN 772
            ..::|   |.||.|..           ||:.                             :.|..
Worm   693 PSRNA---PHQLEDGC-----------CCAH-----------------------------ARAPR 714

  Fly   773 GNGGASPLELRESGNSPCLSRCSSTHSKRRKHPLGDNPNGSSIGNANGESHEQDSWSDEEG---- 833
            ....|.|:                |.|.|.:.|   .|..:...||       :|:.|.|.
Worm   715 AKSIAVPM----------------TSSSRARSP---TPYDNDFENA-------ESFVDPESPKNL 753

  Fly   834 ----------ETTDYKYALRRRSIGRQPIARGMRPRRSYKAPLSQKIAIHKRNVVIVSDEEENTS 888
                      |:|.|..||....:...||...  |..:|..|.         :|.:|.:|..|..
Worm   754 KNLEKIVNLPESTSYDEALCNSDVTMNPIYTS--PITTYSNPC---------HVELVDEENANDV 807

  Fly   889 EYSHSPSSQHSTLESNTDIADMKKTQATSTSSNSYSEPEDDSSDSSDEEQGNRPTEAKAEGPALP 953
            :.:.|..|:    .|.:|.||::.::....:.|:......:|.|.......::.|...:...:|.
Worm   808 DLTSSMDSR----RSRSDDADVESSEEDEGNGNNILNTSMESEDLRYRIDTSQSTMMSSLERSLE 868

  Fly   954 MGAVRSSDI-----------ISIPTFEADGA 973
            :||.||..:           :||.|....|:
Worm   869 IGATRSDGLSDNEMRVQAVKMSIKTHRRTGS 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STYKc	161..400	CDD:214568	140/239 (59%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	136/236 (58%)
dlk-1	NP_001021443.1	PKc_like	141..377	CDD:304357	136/235 (58%)
dlk-1	NP_001021443.1	S_TKc	141..374	CDD:214567	135/232 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161738
Domainoid	1	1.000	289	1.000	Domainoid score	I843
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H120233
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2281
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003049
OrthoInspector	1	1.000	-	-		oto19993
orthoMCL	1	0.900	-	-		OOG6_105153
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2490
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.720