Protein Alignment wnd and Btk

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_038510.2
• Gene: Btk / 12229
• MGIID: 88216
• Length: 659
• Species: Mus musculus
• Alignment Length: 266
• Identity: 89/266 - (33%)
• Similarity: 144/266 - (54%)
• Gaps: 15/266 - (5%)

  Fly   154 WQIPFESITELEWLGSGAQGAVFSGRLKNE-TVAVKKVKE--LKETDI----KHLRKLDHENIIK 211
            |:|..:.:|.|:.||:|..|.|..|:.:.: .||:|.::|  :.|.:.    |.:..|.||.:::
Mouse   395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQ 459

  Fly   212 FKGVCT-QSPVFCIIMEFCPYGPLQNILKEEQVMLPS-RLVSWSKQIALGMQYLHSHKIIHRDLK 274
            ..|||| |.|:| ||.|:...|.|.|.|:|.:....: :|:...|.:...|:||.|.:.:||||.
Mouse   460 LYGVCTKQRPIF-IITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLA 523

  Fly   275 SPNILISTNEVVKISDFGTSREW--NEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLW 337
            :.|.|::...|||:||||.||..  :|.::.:.....|.|..|||:.....|.|.|||::||::|
Mouse   524 ARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMW 588

  Fly   338 EMLTC-EIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSH-L 400
            |:.:. ::||:...:|.....:. ..|:|..|....|....::..||..|...||||:.:||: |
Mouse   589 EIYSLGKMPYERFTNSETAEHIA-QGLRLYRPHLASERVYTIMYSCWHEKADERPSFKILLSNIL 652

  Fly   401 DIAGPE 406
            |:...|
Mouse   653 DVMDEE 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	84/248 (34%)
Btk	NP_038510.2	PH_Btk	6..166	CDD:269944
		Inositol-(1,3,4,5)-tetrakisphosphate 1-binding. /evidence=ECO:0000250|UniProtKB:Q06187	12..24
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..210
		SH3_BTK	217..271	CDD:212839
		SH2_Tec_Btk	274..378	CDD:198260
		PTKc_Btk_Bmx	397..652	CDD:173657	85/256 (33%)
		CAV1-binding. /evidence=ECO:0000250|UniProtKB:Q06187	581..588		3/6 (50%)