Protein Alignment wnd and map3k20

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: XP_002934652.2
• Gene: map3k20 / 100495797
• XenbaseID: XB-GENE-985435
• Length: 790
• Species: Xenopus tropicalis
• Alignment Length: 884
• Identity: 215/884 - (24%)
• Similarity: 349/884 - (39%)
• Gaps: 245/884 - (27%)

  Fly   155 QIPFESITELEWLGSGAQGAVFSGR--LKNETVAVKKVKEL-KETDIKHLRKLDHENIIKFKGVC 216
            ||.|:.:...|..|.|:.|:|:..:  .:::.|||||:.:: ||.:|  |..|.|.|:|:|.|..
 Frog    10 QIKFDDLQFFENCGGGSFGSVYRAKWLSQDKEVAVKKLLKIEKEAEI--LSMLSHRNVIQFYGAV 72

  Fly   217 TQSPVFCIIMEFCPYGPLQNILK--EEQVMLPSRLVSWSKQIALGMQYLHSH---KIIHRDLKSP 276
            .:.|.:||:.|:...|.|.:.:.  ..:.|....:::||..:|.||.|||..   ::|||||||.
 Frog    73 LEPPNYCIVTEYAACGSLYDYINSTRSENMDMDHIMAWSMDVAKGMHYLHMEAPIRVIHRDLKSR 137

  Fly   277 NILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLT 341
            |::|:.:.::||.|||.|| ::..:|.||..||..|||||||::.|.||..|.:|||||||||||
 Frog   138 NVVITMDGILKICDFGASR-FHSHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLT 201

  Fly   342 CEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSHLD-IAGP 405
            .|:|:|.::...:.|.|...:.:|.:||:||:.|..|:..||::..:.||||:||:|:|: ::..
 Frog   202 REVPFKGLEGLQVAWLVVEKNERLTIPSSCPQSFAELMHQCWEADSKKRPSFKQIISNLESMSND 266

  Fly   406 ELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTNIHKYEQDLIKRRTAEWRHAQDIRMVYEDKL- 469
            ..|......:...:..|:.|:...|:.:.:...::...||:|.:|.    :|.:    ::|.||
 Frog   267 SKLPDQCNSFLHNKAEWRCEIEETLERLKRLERDLSYKEQELKERE----KHLK----MWEKKLT 323

  Fly   470 -QKTNQLFFELSEC----------MSQLQEKEKE-------------------IAERERKLPGSG 504
             |....|......|          |.||.:.:.|                   :.||:.|..|..
 Frog   324 EQSHTPLLPSFDICAWTEEDVYVWMQQLVKSDDENMYASLFRQHHITGKRLLLLEERDLKDMGIV 388

  Fly   505 YKPN-RRFGNTIRKMQHYRRRLNPAPAAIQQQSTTPDPE-----------------TTPESPVKC 551
            .|.: ......|.|:.|....|...|..|:...:..|.|                 :.||. .|.
 Frog   389 SKGHIIHLKTAIEKLTHDYLNLFHFPPLIKDFESENDEEEKLVNLELVFGYHLKSGSCPED-YKW 452

  Fly   552 MLYAQLDSNCQPKSYLANIIPSSGLGAPMPNK--------------------------------N 584
            .:|.:||.:....:|:.::..:.......|.|                                .
 Frog   453 KMYMELDGDEIAITYIKDVTFNRNQPDVEPLKMTKPPFVMEKWIVGIRENETVECIVTYENDVRT 517

  Fly   585 KKVFRH--------------RRNASGSFGAPPKYSPTRDRRYQSEPENRKVQLVE-RQTQTDAMD 634
            .|:.:|              .::...:..:|...|.::...|:|..:.:.:..:. ||..|
 Frog   518 PKITKHIHKIHWDKMKMQDAVKSVQLAIMSPLLTSESKQSNYESSVDCQWIYTLRMRQMAT---- 578

  Fly   635 VSETDISPSAEAPRSQPIDVPVPNHRQLPLQLQRVQKIAQAQARARSGSTSSAAGAVNPACPSNG 699
              .|....:|..||||  ...:.|..|:...||..:..|.|..|.|:..|
 Frog   579 --PTSPQHAAGLPRSQ--SSSLSNLSQILPYLQNQESYAAAVRRIRASPT--------------- 624

  Fly   700 NSLSTSELTYQDACSSPDQLIDDVMNSNERLDMTECCSDNENLERLGRKVIEFINENRLSIQSNT 764
              |..:.:.|..: |||.|.                     .|.:         |.:.|||||:
 Frog   625 --LQVTSINYSRS-SSPTQF---------------------GLAK---------NLSSLSIQSS- 655

  Fly   765 NSVSNADNGNGGASPLELRESGNSPCLSRCSSTHSKRRKHPLGDNPNGSSIGNANGESHEQDSWS 829
                                .|:|...:...|...:.|.|   ..||.||.      .|.:.|
 Frog   656 --------------------KGSSASSTASDSPSERERAH---RTPNNSSY------QHNRHS-- 689

  Fly   830 DEEGETTDYKYALRRRSIGRQPIARGMRPRRSYKA---------PLSQKIAIHKRNVVI------ 879
                      ..::|||.||.|   .|...::||:         |..|:.....:|..|
 Frog   690 ----------TPMQRRSGGRSP---QMNSGKNYKSYTVTYSHSRPFEQRPQRTNQNRYIPGMPKL 741

  Fly   880 -----VSDEEENTS-------EYSHSPSSQHSTLESNTD 906
                 |:.||:|.:       :||.....|.:|.:|:.|
 Frog   742 ESDAAVNGEEKNNNDGGWIKVDYSKKTHKQTTTSKSHKD 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	99/244 (41%)
map3k20	XP_002934652.2	Protein Kinases, catalytic domain	22..263	CDD:473864	99/243 (41%)
		SAM_superfamily	338..404	CDD:472832	11/65 (17%)