DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wnd and map3k13

DIOPT Version :9

Sequence 1:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_002936577.1	Gene:	map3k13 / 100493878	XenbaseID:	XB-GENE-5753317	Length:	963	Species:	Xenopus tropicalis

Alignment Length:	1019	Identity:	377/1019 - (36%)
Similarity:	505/1019 - (49%)	Gaps:	221/1019 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SSPNLSLDQTDNLRRSMACLQD-----EFGHLGIAATDLPFKSSDLDSPP-------------RL 81
            |||||.:   |.||.....:.|     ..||..|..|...:.|.|..|.|             |.
Frog    18 SSPNLIV---DTLREDKDYMVDYGDHTTIGHHEIKETPEKYDSLDNASSPVTATVLTSVSEDSRD 79

  Fly    82 QHHNNYAEITD-SSAENTCQQRWPPHVGGAGAAFGHPDKPI----------GWMYGLLGCMKPVL 135
            |..|:..::.| ...|||..|...|. |..|:..|:.|..|          |::.||.||::||.
Frog    80 QFENSVLQLRDQDEPENTAPQGSSPS-GDGGSNSGNEDIRIHFSRSGSGNGGFLEGLFGCLRPVW 143

  Fly   136 SFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDIKH 200
            :.|||....:.|.|:.:.|::|||.|:||:|||||||||||.|:.:.|.||:|||:|.|||||||
Frog   144 NIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRGEEVAIKKVREQKETDIKH 208

  Fly   201 LRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHS 265
            ||||.|.|||.|||||||:|.:|:|||:|.:|.|..:|:..:.:.|..||.||..||.||.|||.
Frog   209 LRKLKHPNIIAFKGVCTQAPCYCLIMEYCAHGQLYEVLRAGRKVTPRLLVDWSTGIASGMNYLHL 273

  Fly   266 HKIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIW 330
            ||||||||||||:|::..:.|||||||||:|.::.||||||||||||||||||||||.|||||||
Frog   274 HKIIHRDLKSPNVLVTHADTVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIW 338

  Fly   331 SYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQ 395
            |:||:|||:||.|||||||||||||||||:|||.|.||||||:|||:|:|..|:|||||||||||
Frog   339 SFGVLLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQ 403

  Fly   396 ILSHLDIAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTNIHKYEQDLIKRRTAEWRHAQD 460
            ||.|||||..::|...::.||::|..|:|||:.|.::|...||.||:.:::||:||..|.|||.|
Frog   404 ILMHLDIASADVLGTPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALD 468

  Fly   461 IRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAER----ERKLPGSGYK--PNRRF--GNTIRK 517
            ||..||.||::.|.|:.|||..|.||:.:|||:..|    |:|.||: ||  |.|..  .|::.|
Frog   469 IREHYERKLERANNLYMELSSIMLQLEVREKELIRREQAVEKKYPGT-YKRHPVRPIVHPNSVEK 532

  Fly   518 MQHYRRRLNPAPAAIQQQSTTPDPETTPESPVKCMLYAQLDSNCQPKSYLANIIPSSGLGAPMPN 582
            :   .::..| |:.:..|:..||               .|.|:        .|:.:.|..|
Frog   533 L---IKKKGP-PSRVPSQTKRPD---------------LLKSD--------GIVSAEGSAA---- 566

  Fly   583 KNKKVFRHRRNASGSFGAPPKYSPTRDRRYQSEPENRKVQLVERQTQTDAMDVSETDISP----- 642
                      :||...|:|...|.....||:|:|.:|:..  .:.:..|.:.|.:...||
Frog   567 ----------SASPISGSPKTSSGAGKSRYRSKPRHRRGN--SKGSHADFVGVLKQQESPIPSQQ 619

  Fly   643 --SAEAPRSQPIDVPVPNHRQLPLQLQRVQKI-AQAQARARSGST----SSAAGAVNPACPSNGN 700
              ....|.|.|:....|.|....:...|.|.: ...|..|...:.    ..||...:|.......
Frog   620 SSQHHTPASPPVTPCSPYHETSQVMTTRHQTLNVHGQNIANCANNLRYFGPAAALRSPLSSHAQR 684

  Fly   701 SLSTSELTYQDACSSPDQLIDDVMNSNERL----DMTECCSDNEN-----LERLGRKVIEFINEN 756
            .||.         |||| |:...:.::.|:    :...|..|..|     .|...::..:..|.|
Frog   685 RLSG---------SSPD-LLSSTLEADSRIQPEREYDYCQQDPYNPCPGCTEASVQQDTDTGNWN 739

  Fly   757 RLSIQSNTNSVS---NADNGNGGASP--------LELRESGNS-------------------PCL 791
                  |||.|:   ...:|:...||        .|..|||..                   |.|
Frog   740 ------NTNMVTAEYRTSDGDPPESPRHNLVPENYEKPESGGEQFTSLKAAIGVSALTVPTPPAL 798

  Fly   792 SRCSSTHSKRRKHPLGDNPNGSSIGNANGESHEQDSWSDEEGETTDYKYALRRRSIGRQPIARGM 856
            .|...|..|                  ||:    :|..:|||| .|.:....||.  |.|  |||
Frog   799 PRRIRTLRK------------------NGD----ESSEEEEGE-VDSEVEFPRRH--RPP--RGM 836

  Fly   857 RPRRSYKAPLSQKIAIHKRNVVIVSD-EEENTSEYSHSPSSQHSTLESNTDIADMKKTQATSTSS 920
            ...:||....|:..:        ||| ||.|||::|:||
Frog   837 SSCQSYSTFSSENFS--------VSDGEEGNTSDHSNSP-------------------------- 867

  Fly   921 NSYSEPEDDSSDSSDEEQGNRPTEAKAEGPALPMGAVRSSDIIS 964
                   ||.:.......|::..:..::.|.:|:.....||.:|
Frog   868 -------DDVAGGDKIWHGDKLDDLLSQTPEIPIEISMQSDGLS 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STYKc	161..400	CDD:214568	171/238 (72%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	170/235 (72%)
map3k13	XP_002936577.1	STKc_MAP3K12_13	175..411	CDD:270961	170/235 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	360	1.000	Domainoid score	I956
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1274
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003049
OrthoInspector	1	1.000	-	-		otm47913
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2490
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.990