Protein Alignment wnd and abl1

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: XP_002936228.2
• Gene: abl1 / 100490771
• XenbaseID: XB-GENE-6054675
• Length: 1128
• Species: Xenopus tropicalis
• Alignment Length: 914
• Identity: 207/914 - (22%)
• Similarity: 335/914 - (36%)
• Gaps: 262/914 - (28%)

  Fly   148 SQRSEDWQIPFESITELEWLGSGAQGAVFSGRLK--NETVAVKKVKE--------LKETDIKHLR 202
            |...:.|:|....||....||.|..|.|:.|..|  |.|||||.:||        |||..:  ::
 Frog   256 SPNYDKWEIERTDITMKHKLGGGQYGEVYEGVWKKYNLTVAVKTLKEDTMEVEEFLKEAAV--MK 318

  Fly   203 KLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKE--EQVMLPSRLVSWSKQIALGMQYLHS 265
            ::.|.|:::..||||:.|.|.||.||..||.|.:.|::  .|.:....|:..:.||:..|:||..
 Frog   319 EVKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRDCNRQEVTAVVLLHMATQISSAMEYLEK 383

  Fly   266 HKIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGT---VAWMAPEVIRNEPCSEKV 327
            ...|||||.:.|.|:..|.:||::|||.||.... .|..:.||.   :.|.|||.:.....|.|.
 Frog   384 KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG-DTYTAHAGAKFPIKWTAPESLAYNKFSIKS 447

  Fly   328 DIWSYGVVLWEMLTCEI-PYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRP 391
            |:|::||:|||:.|..: ||..:|.|. ::.:.....::..|..|||....|::.||:..|.:||
 Frog   448 DVWAFGVLLWEIATYGMSPYPGIDLSQ-VYELLEKDYRMERPEGCPEKVYELMRECWQWSPLDRP 511

  Fly   392 SFRQILSHLDIAGPELLRKTEKQYFET---QKSWKEEVRSHLKEITQNG-----TNIHKYEQDLI 448
            ||.:|  |.|              |||   :.|..:||.   ||:.:.|     :|:.:..:...
 Frog   512 SFAEI--HQD--------------FETMFQESSISDEVE---KELGKKGLKVTVSNLLQAPELPT 557

  Fly   449 KRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAERE--------RKLPGSGY 505
            |.|..        |.|.|.|        .|.:|..|.....|.::.|.|        ||..|:|
 Frog   558 KTRIT--------RRVPESK--------DENAETASVRAAGELDVFEPESAVSPLLPRKERGAG- 605

  Fly   506 KPNRRFGNTIRKMQHYRRRLNPAPAAIQQQSTTPDPETTPESPVKCMLYAQLDSNCQPKSYLANI 570
                                         ....||                 |....||....|:
 Frog   606 -----------------------------DGVLPD-----------------DDRLLPKDKKTNL 624

  Fly   571 IPSSGLGAPMPNKNKKVFRHRRNASGSFGAPPKYSPT-RDRRYQSEPENRKVQLVERQTQTDAMD 634
            ..|:           .:.|.::||.    .|||.|.: ||....||         .|.|..:..:
 Frog   625 FFST-----------LIKRKKKNAP----TPPKRSSSFRDMEGHSE---------RRSTDGEGKE 665

  Fly   635 VSETDISPSAEAPRSQPIDVPVPNHRQLPLQLQRVQKIAQAQARARSGSTSSAAGAVN------- 692
            .:..|:..:.                          |::.......:||...:.|.::
 Frog   666 ANGGDLLDTF--------------------------KLSTNGTALSNGSIQGSTGFLSSQWKKSS 704

  Fly   693 -----PACPSNGNSLSTSELTYQDACSS---PDQLIDDVMNS---NERLDMTECCSDNENLERLG 746
                 .|.||...::.::...:..:||:   |....|....|   ...:..:.|..|....:.|.
 Frog   705 TMTGRQASPSEEETICSTSKRFLRSCSASCMPHGAKDTEWKSVTLPREITSSRCLLDTPGSDSLK 769

  Fly   747 RKVIEFINENRLSIQSNTNSVSNADNGNGGASPLE-------------LRESGNSPCLSRCSSTH 798
            :       ..:.::.....:.|..:...|..:|..             .:::..||..|..|.|.
 Frog   770 K-------AEKPALPRKRGNESKPEGTRGTVTPPPRLPKKCEDPNDEVFKDADPSPNSSPPSLTP 827

  Fly   799 SKRRKHPLGDNPNGS-------------SIGNANGESHEQDSWSDEEGETTDYKYALRRRSIGRQ 850
            ...|:.|.|  |.|:             |:.:..|.|.:|.|::.:    ::.:..|||.... :
 Frog   828 KLLRRKPAG--PAGAPLQKEEASNIRLGSVNSDTGPSTKQTSFAGK----SEAELRLRRPKTS-E 885

  Fly   851 PIARG----MRPRRSYKAPLSQKIAIHKRNVVIVSDEEENTSEYSHSPSSQHST--------LES 903
            |..:.    ::.:.|...|||        ::........|..:.:..||..|.|        |.|
 Frog   886 PATKDKVKVLKVKPSPPLPLS--------SIGSSPSASSNLGKAAKPPSQSHDTSPSEPKHKLTS 942

  Fly   904 NTDIADMKKTQATSTSSN------SYSEPEDDSSDS------SDEEQGNRPTEAKAEGPALPMGA 956
            .||  ::.||......|:      |.|:|:.....|      .|:.|.:.|:.:.:.. .:|:.:
 Frog   943 QTD--ELSKTPPPVPDSSKKPVLLSSSKPQVTGKLSGGMVAGGDQSQPSAPSSSSSTA-FVPLIS 1004

  Fly   957 VRSS 960
            .|.|
 Frog  1005 TRVS 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	92/251 (37%)
abl1	XP_002936228.2	SH3_Abl	92..145	CDD:212784
		SH2_ABL	150..243	CDD:198189
		PTKc_Abl	262..524	CDD:270645	99/281 (35%)
		F_actin_bind	1003..1128	CDD:471692	2/6 (33%)