Protein Alignment wnd and map3k12

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: XP_004912001.1
• Gene: map3k12 / 100488307
• XenbaseID: XB-GENE-482768
• Length: 814
• Species: Xenopus tropicalis
• Alignment Length: 932
• Identity: 350/932 - (37%)
• Similarity: 478/932 - (51%)
• Gaps: 201/932 - (21%)

  Fly    51 MACLQD------EFGHLGIAATDLPFKSSDLDSPPRL----------------------QHHNN- 86
            ||||.:      .|..|   .:|.|.:..|:|:||..                      ..||:
 Frog     1 MACLHETRTPSPSFASL---LSDGPIRRLDIDTPPGCTPEQELTPTQCVLRGVVRSEGGSPHNDD 62

  Fly    87 -YAEITDSSAENTCQQRWPPHVGGAGAAFGHPDKP--------------IGWMYGLLGCMKPVLS 136
             ...:|.|.:::  .|:.....||..|.....|:|              :|::.||.||::||.:
 Frog    63 CTTPLTHSVSQD--PQKAEDRGGGGAADCPLEDRPCRALGEGRMQCQAGVGFLGGLFGCLRPVWA 125

  Fly   137 FIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDIKHL 201
            .||||...|.| |..:.|::|||.|.:|:|:|||||||||.|:...:.||||||:::||||||||
 Frog   126 MIGKTYSTEHK-QGEDPWEVPFEEIQDLQWVGSGAQGAVFLGKFHGDEVAVKKVRDIKETDIKHL 189

  Fly   202 RKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSH 266
            |||.|.|||.|||||||:|.:||:||||..|.|..:|:..:.:.||.||.||..||.||.|||.|
 Frog   190 RKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRKITPSLLVDWSMGIAGGMNYLHLH 254

  Fly   267 KIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWS 331
            |||||||||||:||:.:::|||||||||:|.::.||||||||||||||||||||||.||||||||
 Frog   255 KIIHRDLKSPNMLITYDDLVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWS 319

  Fly   332 YGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQI 396
            :||||||:||.|||||||||||||||||:|||.|.|||:||:|||||::.||.||||||||||||
 Frog   320 FGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKLLLRQCWDSKPRNRPSFRQI 384

  Fly   397 LSHLDIAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTNIHKYEQDLIKRRTAEWRHAQDI 461
            |.|||||..::|...::.||::|..|::|||.|.::|...||.:.:.|::||.||..|.|||.||
 Frog   385 LCHLDIASADVLSTPQETYFKSQVEWRDEVRLHFEKIKSEGTCLQRLEEELITRRREELRHALDI 449

  Fly   462 RMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAERERKLPGSGYKPNRRFGNTIRKMQHYRRRLN 526
            |..||.|||:.|.|:.||:..|.||:.||||:..||:.|       .:::
 Frog   450 REHYERKLQRANTLYVELNSLMLQLELKEKELLRREQIL-------EKKY--------------- 492

  Fly   527 PAPAAIQQQSTTPDPETTPESPVKCMLYAQLDSNCQPKSYLANIIPSSGLGAPMPNKNKKVFRHR 591
              ||.::||   |.|.:|.|..:|   ...:.....|.....:|:.|..|   :|..:..:  ..
 Frog   493 --PAILRQQ---PRPSSTVEKLIK---KRNVPQKLSPHGKRPDILKSEVL---LPKVDSVL--SP 544

  Fly   592 RNASGSFGAPPKYSPTRDRRYQSEPENRKVQLVERQTQTDAMDVSETDISPSAEAPRSQPIDVPV 656
            ...:|....||  ||.|.||  .:|..||.:        |.::: ...::|. ..|:|||
 Frog   545 STPTGCQKLPP--SPGRGRR--GKPRYRKAK--------DMVNL-RAAVTPE-PTPQSQP----- 590

  Fly   657 PNHRQLPLQLQRVQKI-AQAQARARSGSTSSAAGAVN--PACPSNGNSLSTSELTYQDACSSPDQ 718
            |.....||.......: ...:|.||.||.|:.:..|.  |..|                  |||
 Frog   591 PARDPHPLSSSSPDLLCTPLEAEARRGSQSAESSPVRSLPGPP------------------SPD- 636

  Fly   719 LIDDVMNSNERLDMTECCSDNENL---ERLGRKVIEFINENRLSIQSNTNSVSNADNGNGGASPL 780
                  :.:.|...:......::|   .||.|..:....:..||.:.....|.         |.|
 Frog   637 ------SPSGRAAGSRAARGGQHLTPSARLYRAAVTRSQKRGLSSEEEEGEVD---------SEL 686

  Fly   781 EL--RESGNSPCLSRCSSTHSKRRKHPLGDNPNGSSIGNANGESHEQDSWSD-EEGETTDYKYAL 842
            |:  |:||...|            :.|.|.:.|         :|...::.|| |||.|||..:::
 Frog   687 EMERRQSGGVTC------------RWPTGMSQN---------QSPSSENLSDGEEGNTTDPSHSV 730

  Fly   843 RRRSIGRQPIARGMRP--------RRSYKAP---------LSQKIAIHKR-------------NV 877
            ....:...   ...||        .:|.:.|         ||:|.|:.::             ||
 Frog   731 TPDVLSTN---TDERPDDRSEDLVSQSSEPPLDLLTQSDGLSEKEAVIQKVKTQLSNEQTAGENV 792

  Fly   878 VIVSDEEENTSEYSHSPSSQHS 899
            |:..|.:.:::|..||.|:..|
 Frog   793 VLYDDSDCDSAELDHSLSATTS 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	172/235 (73%)
map3k12	XP_004912001.1	STKc_MAP3K12_13	155..391	CDD:270961	172/235 (73%)