Protein Alignment wnd and map3k7

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: XP_012818037.1
• Gene: map3k7 / 100101764
• XenbaseID: XB-GENE-481530
• Length: 617
• Species: Xenopus tropicalis
• Alignment Length: 674
• Identity: 167/674 - (24%)
• Similarity: 274/674 - (40%)
• Gaps: 191/674 - (28%)

  Fly   133 PVLSFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKE-- 195
            |||:|                .:|.::.|...|.:|.|..|.|...:.:.:.||:|:::...|
 Frog    13 PVLNF----------------EEIDYKEIEVEEVVGRGTFGVVCKAKWRGKDVAIKQIESESERK 61

  Fly   196 ---TDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLP----SRLVSWS 253
               .:::.|.:::|.||:|..|.|. :|| |::||:...|.|.|:|...: .||    :..:||.
 Frog    62 AFIVELRQLSRVNHPNIVKLYGACL-NPV-CLVMEYAEGGSLYNVLHGAE-PLPYYTAAHAMSWC 123

  Fly   254 KQIALGMQYLHSHK---IIHRDLKSPN-ILISTNEVVKISDFGTSREWNEISTKM-SFAGTVAWM 313
            .|.|.|:.||||.|   :||||||.|| :|::...|:||.||||:   .:|.|.| :..|:.|||
 Frog   124 LQCAQGVAYLHSMKPKALIHRDLKPPNLLLVAGGTVLKICDFGTA---CDIQTHMTNNKGSAAWM 185

  Fly   314 APEVIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSA--IIWGVGNNSLKLLVPSTCPEGFK 376
            ||||......|||.|::|:|::|||::|...|:.::...|  |:|.|.|.:...|: ...|:..:
 Frog   186 APEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLI-KNLPKPIE 249

  Fly   377 LLVKLCWKSKPRNRPSFRQ---ILSHL--DIAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQN 436
            .|:..||...|..|||..:   |::||  ...|.::..:...||.:..:|..........:||..
 Frog   250 SLMTRCWSKDPPQRPSMEEIVKIMTHLMQYFPGADVSLQYPCQYSDEGQSNSATSTGSCIDITST 314

  Fly   437 GT------NIH------KYEQDLIKRRTAEWRHAQDIRMVYEDKLQKTNQLFFELS-----ECMS 484
            .|      ||.      ....|.|||  .|.:.||.::. ...:..:|.:|....|     |.:|
 Frog   315 NTSNKSDINIEAGDFQASASNDTIKR--IESKLAQHLKN-QSKQSGETGRLSLPPSRGSSVESLS 376

  Fly   485 QLQEK-------------EKEIAERERKL---------PGSGYKPNRRFGNTI------------ 515
            :::.:             ..:::|.|.::         |..|::....|||.:
 Frog   377 EIRGRPPSTLGTSEGKRMSADMSELEARISASTAAYAKPKRGHRKTASFGNILDVPEIIITAGNG 441

  Fly   516 ------------------RKMQHYRRRLNPAPAAIQQQSTTPD--PETTPESPVKC--------- 551
                              ::.::..|..:|:...|.....|||  |...|..|.:.
 Frog   442 QQRRRSVQDLTIVGTESSQESRNSSRSSSPSVRMITTSGPTPDKPPRGLPWGPDESSDTNGSDNS 506

  Fly   552 --MLYAQLDSNCQPKSYLANIIPSSGLGAPMPNKNKK--VF-RHRRNASGSFGAPPKYSPTRDRR 611
              |.|..||...||.             ||.||..:.  || :|.:.|.
 Frog   507 IPMAYLTLDHQLQPL-------------APCPNSKESMAVFEQHCKMAQ---------------- 542

  Fly   612 YQSEPENRKVQ-----LVERQTQTDA-MDVSETDISPSAEAPRSQPIDVPVPNHRQL-------- 662
                 |..|||     |::|:.:..| :|..|.|         .|.....|..|::|
 Frog   543 -----EYMKVQTEIALLLQRKQELIAELDQDEKD---------QQNTSRLVQEHKKLLDENKSLS 593

  Fly   663 --PLQLQRVQKIAQAQARARSGST 684
              ..|.::..::.::|.:.|.|::
 Frog   594 TYYQQCKKQLEVIRSQQQKRQGTS 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	91/256 (36%)
map3k7	XP_012818037.1	STKc_TAK1	31..281	CDD:270960	91/256 (36%)