DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment asf1 and Asf1a

DIOPT Version :9

Sequence 1:	NP_001189131.1	Gene:	asf1 / 40141	FlyBaseID:	FBgn0029094	Length:	218	Species:	Drosophila melanogaster
Sequence 2:	NP_079817.1	Gene:	Asf1a / 66403	MGIID:	1913653	Length:	204	Species:	Mus musculus

Alignment Length:	209	Identity:	129/209 - (61%)
Similarity:	157/209 - (75%)	Gaps:	17/209 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKVHITNVVVLDNPSSFFNPFQFELTFECIEELKEDLEWKMIYVGSAESEEHDQVLDTIYVGPV 65
            ||||.:.|||||||||.|:||||||:||||||:|.||||||:||||||||||:|||||::.||||
Mouse     1 MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPV 65

  Fly    66 PEGRHIFVFQADPPDVSKIPEPDAVGVTIVLLTCSYRGQEFVRVGYYVNNDYADPEMRENPPTKP 130
            |.|||:||||||.|:...||:.||||||:||:||:||||||:||||||||:|.:.|:|||||.||
Mouse    66 PAGRHMFVFQADAPNAGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKP 130

  Fly   131 LFEKLTRNILASKPRVTRFKINWDYGHINGNGNGVENGH------QDEMATDG-PSTSEAASAVI 188
            .|.||.||||||.||||||.|||:     .|...:|:..      |..::||. ||.|:..|.
Mouse   131 DFSKLQRNILASNPRVTRFHINWE-----DNTEKLEDAESSNPNLQSLLSTDALPSASKGWST-- 188

  Fly   189 HPEDDNSLAMPMEN 202
               .:|||.:.:|:
Mouse   189 ---SENSLNVMLES 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
asf1	NP_001189131.1	ASF1_hist_chap	1..154	CDD:282572	115/152 (76%)
Asf1a	NP_079817.1	Interaction with histone H3, CHAF1B, and HIRA. /evidence=ECO:0000250	1..156		116/159 (73%)
		ASF1_hist_chap	1..154	CDD:398417	115/152 (76%)
		Required for interaction with HIRA. /evidence=ECO:0000250	31..37		3/5 (60%)
		Required for interaction with HIRA. /evidence=ECO:0000250	155..204		13/50 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835909
Domainoid	1	1.000	255	1.000	Domainoid score	I2032
eggNOG	1	0.900	-	-		E1_COG5137
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8528
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3160
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54218
OrthoDB	1	1.010	-	-		D1334998at2759
OrthoFinder	1	1.000	-	-		FOG0001913
OrthoInspector	1	1.000	-	-		otm44071
orthoMCL	1	0.900	-	-		OOG6_101293
Panther	1	1.100	-	-	LDO	PTHR12040
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R94
SonicParanoid	1	1.000	-	-		X1264
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800