DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lon and PIM1

DIOPT Version :9

Sequence 1:	NP_730435.2	Gene:	Lon / 40138	FlyBaseID:	FBgn0036892	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	NP_009531.1	Gene:	PIM1 / 852259	SGDID:	S000000118	Length:	1133	Species:	Saccharomyces cerevisiae

Alignment Length:	998	Identity:	429/998 - (42%)
Similarity:	599/998 - (60%)	Gaps:	129/998 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 VPDVWPHVPLLAMRKNPLFPRFMKIVEVSNPIIMDLLRRKVKLNQPYVGVF-LKKTDGEEELITN 150
            ||:|:|.:..|.:.:.||||.|.|.|.:|:..:|..::..:...|||:|.| ||.::.:.::||:
Yeast   175 VPEVYPQMLALPIARRPLFPGFYKAVVISDERVMKAIKEMLDRQQPYIGAFMLKNSEEDTDVITD 239

  Fly   151 LNDVYNLGTFAQIQELQDLGDK------LRMVVVAHRRIRITGQVVEDVPPPKPVKMTTLHYPLF 209
            .||||::|..|||.......|:      :..::..||||:|     :::.||...|..:
Yeast   240 KNDVYDVGVLAQITSAFPSKDEKTGTETMTALLYPHRRIKI-----DELFPPNEEKEKS------ 293

  Fly   210 NIKLQIPAEDQSTDQADAA--PIKSRSDPARKPR------GRIPRSRTGKSRESAAAEELIQNQT 266
              |.|....|..|...:.|  |....|.....|:      .|||.|.....:...|.||
Yeast   294 --KEQAKDTDTETTVVEDANNPEDQESTSPATPKLEDIVVERIPDSELQHHKRVEATEE------ 350

  Fly   267 LEPPLKSGKVESSSLPKPPTEEKIVEPE----TGAKENVNQSAPSAQPVLIVEVENVK-QPIYKQ 326
                      ||..|      :.|.|.|    |...:|.|        |.:|.|.|:: :|..::
Yeast   351 ----------ESEEL------DDIQEGEDINPTEFLKNYN--------VSLVNVLNLEDEPFDRK 391

  Fly   327 TEEVKALTQEIIKTLRDIITMNPLYRESLQQMLHQNQ----RVVDNPIYLCDLGASLSAGEPAEL 387
            :..:.|||.||:|..::|..:|.::||.:.......|    .:.:.|..|.|..|::||||..||
Yeast   392 SPVINALTSEILKVFKEISQLNTMFREQIATFSASIQSATTNIFEEPARLADFAAAVSAGEEDEL 456

  Fly   388 QKILEETDIPERLQLALTLLKKELELSRLQQKIGREVEEKVKQQHRKYILQEQLKVIKKELGIEK 452
            |.||...:|..||:.:|.:|||||..:.||.||.::||.|::::.|:|.|.||||.||:||||:
Yeast   457 QDILSSLNIEHRLEKSLLVLKKELMNAELQNKISKDVETKIQKRQREYYLMEQLKGIKRELGID- 520

  Fly   453 DDKDAIGEKYREKLKDKVVPEAIMTVIDEELTKLNFLESHSSEFNVTRNYLDWLTSLPWGVISTE 517
            |.:|.:.:.|:|::|...:|:::..:.|:|:|||:.||:..|||.|.|||||||||:|||..|.|
Yeast   521 DGRDKLIDTYKERIKSLKLPDSVQKIFDDEITKLSTLETSMSEFGVIRNYLDWLTSIPWGKHSKE 585

  Fly   518 NLCLEKATETLNDDHYGMEDIKKRILEFIAVSSLKGSTQGKILCFHGPPGVGKTSIAKSIARALN 582
            ...:.:|.:.|::|||||.|:|.||||||||..|.|...|||:||.||||||||||.||||||||
Yeast   586 QYSIPRAKKILDEDHYGMVDVKDRILEFIAVGKLLGKVDGKIICFVGPPGVGKTSIGKSIARALN 650

  Fly   583 REYFRFSVGGMTDVAEIKGHRRTYVGAMPGKLIQCLKKTKIENPLVLIDEVDKIGK-GYQGDPSS 646
            |::|||||||||||||||||||||:||:||:::|.|||.:.:|||:||||:||||. |..||||:
Yeast   651 RKFFRFSVGGMTDVAEIKGHRRTYIGALPGRVVQALKKCQTQNPLILIDEIDKIGHGGIHGDPSA 715

  Fly   647 ALLELLDPEQNANFLDHYLDVPVDLSRVLFICTANVIDTIPEPLRDRMELIEMSGYVAEEKIAIA 711
            ||||:||||||.:|||:|||:|:|||:|||:||||.::|||.||.||||:||::|||||:|:.||
Yeast   716 ALLEVLDPEQNNSFLDNYLDIPIDLSKVLFVCTANSLETIPRPLLDRMEVIELTGYVAEDKVKIA 780

  Fly   712 RQYLMPQAMKDCGLTDKHINISEDALNMLIRSYCRESGVRNLQKHIEKVIRKVAFRVVKK----- 771
            .|||:|.|.|..||.:.|::::|||:..|::.||||||||||:|||||:.||.|.:||||
Yeast   781 EQYLVPSAKKSAGLENSHVDMTEDAITALMKYYCRESGVRNLKKHIEKIYRKAALQVVKKLSIED 845

  Fly   772 -------------------------------------------------EGEHFPVNADNLTTFL 787
                                                             |..:..::..||..::
Yeast   846 SPTSSADSKPKESVSSEEKAENNAKSSSEKTKDNNSEKTSDDIEALKTSEKINVSISQKNLKDYV 910

  Fly   788 GKQIFSSDRMYATTPVGVVMGLAWTAMGGSSLYIETSRRHIRQGAKTDPNTVAGSLHITGNLGDV 852
            |..::::||:|.|||.|||||||||.|||.|||:|:.........|..      :...||.||||
Yeast   911 GPPVYTTDRLYETTPPGVVMGLAWTNMGGCSLYVESVLEQPLHNCKHP------TFERTGQLGDV 969

  Fly   853 MKESAQIALTVARNFLYSLEPNNLFLEQEHIHLHVPEGATPKDGPSAGITIITALVSLATGKPVR 917
            ||||:::|.:.|:.:|....|.|.|.|:..||||.|||||||||||||:|:.|:.:|||..|.:.
Yeast   970 MKESSRLAYSFAKMYLAQKFPENRFFEKASIHLHCPEGATPKDGPSAGVTMATSFLSLALNKSID 1034

  Fly   918 QDIAMTGEVSLKGKVLPVGGIKEKTIAARRSGVNCLILPVDNKKDFEELPTYITDGLEVHFATTY 982
            ..:|||||::|.||||.:||::||.:||:|||...:|.|.||..|:||||..:.:|||...|..|
Yeast  1035 PTVAMTGELTLTGKVLRIGGLREKAVAAKRSGAKTIIFPKDNLNDWEELPDNVKEGLEPLAADWY 1099

  Fly   983 EDVYKIAFTDVTETTTNNVEEQE 1005
            .|:::..|.||.....|:|.:.|
Yeast  1100 NDIFQKLFKDVNTKEGNSVWKAE 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lon	NP_730435.2	LON	93..>148	CDD:197740	17/55 (31%)
		lon	95..990	CDD:273258	419/973 (43%)
		P-loop_NTPase	530..>581	CDD:304359	37/50 (74%)
		AAA	560..702	CDD:278434	104/142 (73%)
		ChlI	778..991	CDD:304493	100/212 (47%)
PIM1	NP_009531.1	lon	183..1107	CDD:273258	419/973 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343060
Domainoid	1	1.000	220	1.000	Domainoid score	I459
eggNOG	1	0.900	-	-		E1_COG0466
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3521
Inparanoid	1	1.050	737	1.000	Inparanoid score	I77
Isobase	1	0.950	-	0	Normalized mean entropy	S666
OMA	1	1.010	-	-		QHG55281
OrthoFinder	1	1.000	-	-		FOG0002884
OrthoInspector	1	1.000	-	-		oto100356
orthoMCL	1	0.900	-	-		OOG6_100411
Panther	1	1.100	-	-	LDO	PTHR43718
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R662
SonicParanoid	1	1.000	-	-		X2242
TreeFam	1	0.960	-	-
	16	15.740