DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lon and LON4

DIOPT Version :9

Sequence 1:	NP_730435.2	Gene:	Lon / 40138	FlyBaseID:	FBgn0036892	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	NP_566259.1	Gene:	LON4 / 819748	AraportID:	AT3G05790	Length:	942	Species:	Arabidopsis thaliana

Alignment Length:	1066	Identity:	429/1066 - (40%)
Similarity:	592/1066 - (55%)	Gaps:	247/1066 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RNRPIQSSLMQYCRDRSLRLQRLHGANLMVQRFYSRKRDDSNGDIIMGPDLMSDQDTHLPATVAV 87
            |:.|:::.|.:       :|..|.|.|   :..|...|...:.|:        |.||....|..
plant    22 RSTPVKNLLFK-------QLTLLTGWN---RSSYELGRRSFSSDL--------DSDTKSSTTTV- 67

  Fly    88 PDVWPH------VPLLAMRKNPLFPRFMKIVEVSNPIIMDLLRRKVKLNQPYVGVFLKKTDGE-- 144
             ...||      |..|.:...||.|.|...:.|.:|.::..|:...:...||.|.||.|.|..
plant    68 -SAKPHLDDCLTVIALPLPHKPLIPGFYMPIYVKDPKVLAALQESRRQQAPYAGAFLLKDDASSD 131

  Fly   145 -------EELITNL------NDVYNLGTFAQIQELQDLGDKLRMVVVAHRRIRITGQVVEDVPPP 196
                   |.::..|      |.::.:||.|||..:|  |:  :::::.||::|||..|.|...|
plant   132 SSSSSETENILEKLKGKELINRIHEVGTLAQISSIQ--GE--QVILIGHRQLRITEMVSESEDP- 191

  Fly   197 KPVKMTTLHYPLFNIKLQIPAEDQSTDQADAAPIKSRSDPARKPRGRIPRSRTGKSRESAAAEEL 261

plant   192 ----------------------------------------------------------------- 191

  Fly   262 IQNQTLEPPLKSGKVESSSLPKPPTEEKIVEPETGAKENVNQSAPSAQPVLIVEVENVK-QPIYK 325
                                                              |.|:|:::| :|..|
plant   192 --------------------------------------------------LTVKVDHLKDKPYDK 206

  Fly   326 QTEEVKALTQEIIKTLRDIITMNPLYRESLQ--------QMLHQNQRVVD-NPIYLCDLGASLSA 381
            ..:.:||...:::.||||::....|:|:.::        .:.|..:.:.: |...|.|.||.:|.
plant   207 DDDVIKATYFQVMSTLRDVLKTTSLWRDHVRTYTQACSLHIWHCLRHIGEFNYPKLADFGAGISG 271

  Fly   382 GEPAELQKILEETDIPERLQLALTLLKKELELSRLQQKIGREVEEKVKQQHRKYILQEQLKVIKK 446
            ....:.|.:|||.|:.:||:|.|.|:|||:|::::|:.|.:.||||.....|:.||:||:..|||
plant   272 ANKHQNQGVLEELDVHKRLELTLELVKKEVEINKIQESIAKAVEEKFSGDRRRIILKEQINAIKK 336

  Fly   447 ELGIEKDDKDAIGEKYR---EKLKDKVVPEAIMTVIDEELTKLNFLESHSSEFNVTRNYLDWLTS 508
            |||.|.|.|.|:.||:|   :.:||| :|..::.||:|||.||..||:.||||:||.|||||||.
plant   337 ELGGETDSKSALSEKFRGRIDPIKDK-IPGHVLKVIEEELKKLQLLETSSSEFDVTCNYLDWLTV 400

  Fly   509 LPWGVISTENLCLEKATETLNDDHYGMEDIKKRILEFIAVSSLKGSTQGKILCFHGPPGVGKTSI 573
            ||||..|.||..:.:|.:.|::||||:.|:|:||||||||..|:|::||||:|..||.|||||||
plant   401 LPWGNFSDENFNVLRAEKILDEDHYGLSDVKERILEFIAVGGLRGTSQGKIICLSGPTGVGKTSI 465

  Fly   574 AKSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKLIQCLKKTKIENPLVLIDEVDKIG- 637
            .:||||||:|::|||||||::||||||||||||:||||||::||||....|||||||||:||:|
plant   466 GRSIARALDRKFFRFSVGGLSDVAEIKGHRRTYIGAMPGKMVQCLKNVGTENPLVLIDEIDKLGV 530

  Fly   638 KGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSRVLFICTANVIDTIPEPLRDRMELIEMSGY 702
            :|:.|||:||:||||||||||||||||||||:|||:|||:|||||.||||.||.||||:|.:|||
plant   531 RGHHGDPASAMLELLDPEQNANFLDHYLDVPIDLSKVLFVCTANVTDTIPGPLLDRMEVITLSGY 595

  Fly   703 VAEEKIAIARQYLMPQAMKDCGLTDKHINISEDALNMLIRSYCRESGVRNLQKHIEKVIRKVAFR 767
            :.:||:.|||.||...|.:|||:..:.:::|:.|...||..||||:|||||||.|||:.||:|.:
plant   596 ITDEKMHIARDYLEKTARRDCGIKPEQVDVSDAAFLSLIEHYCREAGVRNLQKQIEKIFRKIALK 660

  Fly   768 VVKK-----------------------------------EG------------------------ 773
            :|:|                                   ||
plant   661 LVRKAASTEVPRISDDVTTDTEETKSLAKTDLESPETSAEGSTVLTDELATGDPTESTTEQSGEV 725

  Fly   774 ----EHFPVNADNLTTFLGKQIFSSDRMYATTPVGVVMGLAWTAMGGSSLYIETSRRHIRQGAKT 834
                |.:.::..||:.::||.:|..:::|..||||||||||||:||||:|||||:  .:.:|..
plant   726 AETVEKYMIDESNLSDYVGKPVFQEEKIYEQTPVGVVMGLAWTSMGGSTLYIETT--FVEEGEG- 787

  Fly   835 DPNTVAGSLHITGNLGDVMKESAQIALTVARNFLYSLEPNNLFLEQEHIHLHVPEGATPKDGPSA 899
                 .|.|||||.|||||||||:||.||||..:...||.|.......:|||||.||||||||||
plant   788 -----KGGLHITGRLGDVMKESAEIAHTVARRIMLEKEPENKLFANSKLHLHVPAGATPKDGPSA 847

  Fly   900 GITIITALVSLATGKPVRQDIAMTGEVSLKGKVLPVGGIKEKTIAARRSGVNCLILPVDNKKDFE 964
            |.|:||:|:|||..||||:|:||||||:|.|::|.:||:||||||||||.|..:|.|..|::||:
plant   848 GCTMITSLLSLALKKPVRKDLAMTGEVTLTGRILAIGGVKEKTIAARRSQVKVIIFPEANRRDFD 912

  Fly   965 ELPTYITDGLEVHFATTYEDVYKIAF 990
            ||...:.:||||||...||.::::||
plant   913 ELARNVKEGLEVHFVDEYEQIFELAF 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lon	NP_730435.2	LON	93..>148	CDD:197740	18/69 (26%)
		lon	95..990	CDD:273258	410/986 (42%)
		P-loop_NTPase	530..>581	CDD:304359	34/50 (68%)
		AAA	560..702	CDD:278434	107/142 (75%)
		ChlI	778..991	CDD:304493	119/213 (56%)
LON4	NP_566259.1	LON	78..>125	CDD:197740	14/46 (30%)
		lon	81..938	CDD:273258	410/985 (42%)
		P-loop_NTPase	408..>475	CDD:304359	40/66 (61%)
		AAA	452..595	CDD:278434	107/142 (75%)
		ChlI	734..938	CDD:304493	117/211 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	247	1.000	Domainoid score	I538
eggNOG	1	0.900	-	-		E1_COG0466
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	744	1.000	Inparanoid score	I110
OMA	1	1.010	-	-		QHG55281
OrthoDB	1	1.010	-	-		D528132at2759
OrthoFinder	1	1.000	-	-		FOG0002884
OrthoInspector	1	1.000	-	-		otm3299
orthoMCL	1	0.900	-	-		OOG6_100411
Panther	1	1.100	-	-	LDO	PTHR43718
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2242
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840