DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lon and Lonp2

DIOPT Version :9

Sequence 1:	NP_730435.2	Gene:	Lon / 40138	FlyBaseID:	FBgn0036892	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	NP_080103.1	Gene:	Lonp2 / 66887	MGIID:	1914137	Length:	852	Species:	Mus musculus

Alignment Length:	830	Identity:	298/830 - (35%)
Similarity:	443/830 - (53%)	Gaps:	123/830 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 IKSRSDPARKPRGRIPRSRTGKSRESAAAEELIQNQTLEPPLKSGKVESSSLPKPPTEEKIVEPE 294
            |.:..|||...:...|..|.|   .:|.|.:::               .|:.|||.....|
Mouse    60 IPNTPDPASDTQDLPPLHRIG---TAALAVQVV---------------GSNWPKPHYTLLI---- 102

  Fly   295 TGAKENVNQSAPSAQPVLIVEVENVKQ-----PIYKQTEEVKALTQEIIKTLRDIITMNPLYRES 354
            ||............:|..:.|||.:.:     .|.|..||:..|:::..:           |...
Mouse   103 TGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNICKSREELGELSEQFYR-----------YAVQ 156

  Fly   355 LQQMLHQN-------QRVVDN--PIYLCDLGASLSAGEPAELQKILEETDIPERLQLALTLLKKE 410
            |.:||..:       :|::||  ...|.|:..|:......|..:||:...:.:|.::.:.||.::
Mouse   157 LVEMLDMSVPAVAKLRRLLDNLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMTIPLLVRQ 221

  Fly   411 LELSRLQQKIGREVEEKVKQQHRKYILQEQLKVIKK--------ELGIEKDDKDAIGEKYREKLK 467
            :|..:|.||     ..|.||...|.::  .::.|::        |...|::|.|.| ....:|::
Mouse   222 IEGLKLLQK-----TRKPKQDDDKRVI--AIRPIRRIPHIPGTLEDEEEEEDNDDI-VMLEKKIR 278

  Fly   468 DKVVPEAIMTVIDEELTKLNFLESHSSEFNVTRNYLDWLTSLPWGVISTENLCLEKATETLNDDH 532
            ...:||....|..:|:.:|..:.....|:.:|||||:.:..|||...:|:.|.:..|...|::||
Mouse   279 TSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDH 343

  Fly   533 YGMEDIKKRILEFIAVSSLKGSTQGKILCFHGPPGVGKTSIAKSIARALNREYFRFSVGGMTDVA 597
            |.||.:|:|:||::||..||.:.:|.||||.|||||||||:.:|:|:.|.||:.|.::||:.|.:
Mouse   344 YAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQS 408

  Fly   598 EIKGHRRTYVGAMPGKLIQCLKKTKIENPLVLIDEVDKIGKGYQGDPSSALLELLDPEQNANFLD 662
            :|:||||||||:|||::|..||...:.||:.|:|||||:||..||||::||||:||||||.||.|
Mouse   409 DIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTD 473

  Fly   663 HYLDVPVDLSRVLFICTANVIDTIPEPLRDRMELIEMSGYVAEEKIAIARQYLMPQAMKDCGLTD 727
            |||:|..|||:||||.|||...|||..|.||||:|::.||..||||.||.::|:|:.::..|||.
Mouse   474 HYLNVAFDLSQVLFIATANTTATIPPALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTP 538

  Fly   728 KHINISEDALNMLIRSYCRESGVRNLQKHIEKVIRKVAFRVVKKEGEH----------------- 775
            :.|.|.:.....:|..|.||:|||:|.:....:.|.||.:|.  ||:|
Mouse   539 QQIQIPQHTTLAIITRYTREAGVRSLDRKFGAICRAVAVKVA--EGQHKEAKLDRSDVADGEGCK 601

  Fly   776 -----------------------FPVNADN--LTTFLGKQIFSSDRMYATTPVGVVMGLAWTAMG 815
                                   .|:..|:  |...||..::..:.....:..||.:|||||.:|
Mouse   602 EHVLEDAKPESISDTADLALPPEMPILIDSHALKDILGPPLYELEVSERLSQPGVAIGLAWTPLG 666

  Fly   816 GSSLYIETSRRHIRQGAKTDPNTVAGSLHITGNLGDVMKESAQIALTVARNFLYSLEPNNLF--- 877
            |..:::|.||   ..|        .|.|.:||.|||||||||.:|::..|:........|.|
Mouse   667 GKIMFVEASR---MDG--------EGQLTLTGQLGDVMKESAHLAISWLRSNAKKYHLTNAFGSF 720

  Fly   878 --LEQEHIHLHVPEGATPKDGPSAGITIITALVSLATGKPVRQDIAMTGEVSLKGKVLPVGGIKE 940
              |:...||||.|.||..|||||||:||:|.|.||.:|:.||.|:|||||::|:|.||||||||:
Mouse   721 DLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKD 785

  Fly   941 KTIAARRSGVNCLILPVDNKKDFEELPTYITDGLEVHFATTYEDVYKIAF 990
            |.:||.|:|:..:|:|..|:||.||:|:.:...|....|:..::|...||
Mouse   786 KVLAAHRAGLKQIIIPQRNEKDLEEIPSNVRQDLSFVTASCLDEVLNAAF 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lon	NP_730435.2	LON	93..>148	CDD:197740
		lon	95..990	CDD:273258	296/828 (36%)
		P-loop_NTPase	530..>581	CDD:304359	29/50 (58%)
		AAA	560..702	CDD:278434	86/141 (61%)
		ChlI	778..991	CDD:304493	92/220 (42%)
Lonp2	NP_080103.1	LON	4..202	CDD:271862	36/174 (21%)
		Lon	11..838	CDD:223542	298/830 (36%)
		AAA	371..513	CDD:278434	86/141 (61%)
		ChlI	629..837	CDD:304493	92/218 (42%)
		Microbody targeting signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03121	850..852
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0466
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100411
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710