DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lon and lonp1

DIOPT Version :9

Sequence 1:	NP_730435.2	Gene:	Lon / 40138	FlyBaseID:	FBgn0036892	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	XP_691712.4	Gene:	lonp1 / 563257	ZFINID:	ZDB-GENE-030131-4006	Length:	966	Species:	Danio rerio

Alignment Length:	959	Identity:	582/959 - (60%)
Similarity:	712/959 - (74%)	Gaps:	73/959 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 CRDRSLRLQRLHGANLMVQRFYSRKRDDSNGDIIMGPDLMSDQDTHLPATVAVPDVWPHVPLLAM 99
            |:.||:...|..|.:.......|...|...||  ..||.........|  :.||:|:|:|||:|:
Zfish    76 CQTRSVFGNRSSGFSGEDGAESSGTADGDGGD--EAPDSPPQMSALTP--MLVPEVFPNVPLIAV 136

  Fly   100 RKNPLFPRFMKIVEVSNPIIMDLLRRKVKLNQPYVGVFLKKTD-GEEELITNLNDVYNLGTFAQI 163
            .:||:||||:||:||.|..:|:||||||:|.|||.|||||:.| .|.:::.:|:.||:.|||.||
Zfish   137 NRNPVFPRFIKIIEVKNKQLMELLRRKVRLAQPYAGVFLKRDDSNESDVVESLDAVYHTGTFVQI 201

  Fly   164 QELQDLGDKLRMVVVAHRRIRITGQVVEDVPPPKPVKMTTLHYPLFNIKLQIPAEDQSTDQADAA 228
            .|:|||||||||:|:.||||||...:..:...|:|              ::..||:|.:.:
Zfish   202 HEMQDLGDKLRMIVMGHRRIRINKALSVEPEEPEP--------------MEAEAEEQKSSR---- 248

  Fly   229 PIKSRSDPARKPRGRIPRSRTGKSRESAAAEELIQNQTLEPPLKSGKVESSSLPKPPTEEKIVEP 293
                     ||.:    |||    ||.....:|::....|..|   :||  :|| ||:
Zfish   249 ---------RKQK----RSR----REPEPLADLMEQTVREADL---RVE--ALP-PPS------- 283

  Fly   294 ETGAKENVNQSAPSAQPVLIVEVENVKQPIYKQTEEVKALTQEIIKTLRDIITMNPLYRESLQQM 358
                             ||:|||:||....::.||||||||.||:||:||||.:|||||||:.||
Zfish   284 -----------------VLMVEVDNVAHEEFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQM 331

  Fly   359 LHQNQRVVDNPIYLCDLGASLSAGEPAELQKILEETDIPERLQLALTLLKKELELSRLQQKIGRE 423
            :...||||||||||.|:||:|:..|..|||.:||||:||:||..||:|||||.|||:|||::|||
Zfish   332 MQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEYELSKLQQRLGRE 396

  Fly   424 VEEKVKQQHRKYILQEQLKVIKKELGIEKDDKDAIGEKYREKLKDKVVPEAIMTVIDEELTKLNF 488
            ||||:||.||||:||||||:||||||:||:|||||.||:||:|:|:.||:.||.||:|||.||..
Zfish   397 VEEKIKQTHRKYLLQEQLKIIKKELGLEKEDKDAIEEKFRERLRDRTVPQHIMDVINEELNKLGL 461

  Fly   489 LESHSSEFNVTRNYLDWLTSLPWGVISTENLCLEKATETLNDDHYGMEDIKKRILEFIAVSSLKG 553
            |::|||||||||||||||||:|||..|.|||.|.:|.|.|.:|||||:|:|||||||||||.|:|
Zfish   462 LDNHSSEFNVTRNYLDWLTSMPWGTNSEENLELRRAKEVLEEDHYGMDDVKKRILEFIAVSQLRG 526

  Fly   554 STQGKILCFHGPPGVGKTSIAKSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKLIQCL 618
            |||||||||:|||||||||||:||||||||||||||||||||||||||||||||||||||:||||
Zfish   527 STQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCL 591

  Fly   619 KKTKIENPLVLIDEVDKIGKGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSRVLFICTANVI 683
            ||||.||||||||||||||:||||||||||||||||||||||||||||||||||:||||||||:.
Zfish   592 KKTKTENPLVLIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANIT 656

  Fly   684 DTIPEPLRDRMELIEMSGYVAEEKIAIARQYLMPQAMKDCGLTDKHINISEDALNMLIRSYCRES 748
            ||||||||||||:|.:|||||:||:|||.:||:||....|||.::.:.|:.:|||:|||.|||||
Zfish   657 DTIPEPLRDRMEMINVSGYVAQEKLAIAEKYLVPQLRTLCGLDEQKVKINPEALNLLIRQYCRES 721

  Fly   749 GVRNLQKHIEKVIRKVAFRVVKKEGEHFPVNADNLTTFLGKQIFSSDRMYATTPVGVVMGLAWTA 813
            |||||||.:|||.||||||:|..|.....|.::||..::||.:|:.||||..||.||||||||||
Zfish   722 GVRNLQKQVEKVFRKVAFRIVSGEETAVDVTSNNLQDYVGKPLFTVDRMYDVTPPGVVMGLAWTA 786

  Fly   814 MGGSSLYIETSRRHIRQ-GAKTDPNTVAGSLHITGNLGDVMKESAQIALTVARNFLYSLEPNNLF 877
            ||||:|:||||.|..|. ..|..|..  |||.:||.|||||||||:||.|.||:||...:|:|.|
Zfish   787 MGGSTLFIETSLRRPRDPPGKDGPKD--GSLEVTGQLGDVMKESAKIAYTFARSFLMKEQPDNEF 849

  Fly   878 LEQEHIHLHVPEGATPKDGPSAGITIITALVSLATGKPVRQDIAMTGEVSLKGKVLPVGGIKEKT 942
            |...|||||||||||||||||||.||:|||:||||...:||::|||||:||.||:||||||||||
Zfish   850 LVSSHIHLHVPEGATPKDGPSAGCTIVTALLSLATNTALRQNVAMTGELSLTGKILPVGGIKEKT 914

  Fly   943 IAARRSGVNCLILPVDNKKDFEELPTYITDGLEVHFATTYEDVYKIAFT 991
            |||:|:||.|:|||.:|:|||.:||.|||:||||||...|.::|.:.|:
Zfish   915 IAAKRAGVTCIILPAENRKDFSDLPEYITEGLEVHFVENYSEIYNLVFS 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lon	NP_730435.2	LON	93..>148	CDD:197740	33/55 (60%)
		lon	95..990	CDD:273258	564/896 (63%)
		P-loop_NTPase	530..>581	CDD:304359	43/50 (86%)
		AAA	560..702	CDD:278434	130/141 (92%)
		ChlI	778..991	CDD:304493	136/213 (64%)
lonp1	XP_691712.4	LON	131..228	CDD:197740	58/96 (60%)
		lon	132..962	CDD:273258	564/896 (63%)
		LON	<340..379	CDD:197740	24/38 (63%)
		P-loop_NTPase	489..>564	CDD:304359	60/74 (81%)
		AAA	533..675	CDD:278434	130/141 (92%)
		ChlI	751..957	CDD:304493	135/207 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577894
Domainoid	1	1.000	275	1.000	Domainoid score	I1724
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3521
Inparanoid	1	1.050	1091	1.000	Inparanoid score	I232
OMA	1	1.010	-	-		QHG55281
OrthoDB	1	1.010	-	-		D157119at33208
OrthoFinder	1	1.000	-	-		FOG0002884
OrthoInspector	1	1.000	-	-		oto39245
orthoMCL	1	0.900	-	-		OOG6_100411
Panther	1	1.100	-	-	LDO	PTHR43718
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2242
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910