DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lon and lonp2

DIOPT Version :9

Sequence 1:	NP_730435.2	Gene:	Lon / 40138	FlyBaseID:	FBgn0036892	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	NP_001008573.1	Gene:	lonp2 / 494030	ZFINID:	ZDB-GENE-041212-1	Length:	840	Species:	Danio rerio

Alignment Length:	978	Identity:	329/978 - (33%)
Similarity:	482/978 - (49%)	Gaps:	196/978 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VAVPDVWPHVPLLAMRKNPLFPRFMKIVEVSNPIIMDLLRRKV----KLNQPYVGVFLKKTDGEE 145
            :.:|.   .:|||......|.|.....|.|.....|.|::.::    .|....:||.....|.|.
Zfish     7 IQIPS---RLPLLCTHDGVLLPGSTMRVSVDTARNMQLVKSRLLKGTSLKSTIIGVIPNTRDPEH 68

  Fly   146 ELITNLNDVYNLGTFAQIQELQDLGDKLRMVVVAHRRIRITGQVVEDVPPPKPVKMTTLHYPLFN 210
            : ...|..::::||                   |...:::.|.     ..|||      ||.|.
Zfish    69 D-SDELPSLHSIGT-------------------AGLAVQVVGS-----NWPKP------HYTLL- 101

  Fly   211 IKLQIPAEDQSTDQADAAPIKSRSDPARKPRGRIPRSRTGKSRESAAAEELIQNQTLEPPLKSGK 275
                                                 .||..|  ....:|::    |.|....:
Zfish   102 -------------------------------------ITGLCR--FRVSQLLR----ERPFPVAE 123

  Fly   276 VESSSLPKPPTEEKIVEPETGAKENVNQSAPSAQPVLIVEVENVKQPIYKQTEEVKA---LTQEI 337
            ||.....:..||.   :|..|                  |:..:.|..|:...::..   ::..:
Zfish   124 VEQLDKLEQYTEG---DPADG------------------ELGELSQRFYQAAVQLVGMLDMSVPV 167

  Fly   338 IKTLRDIITMNPLYRESLQQMLHQNQRVVDNPIYLCDLGASLSAGEPAELQKILEETDIPERLQL 402
            :..||.::...|  :|:|..:                |.|.:......:|| :|:..|:.||.:.
Zfish   168 VAKLRRLLDSLP--KETLPDV----------------LAAMIRTSNKEKLQ-VLDAVDLEERFKK 213

  Fly   403 ALTLLKKELELSRLQQKIGREVEEKVKQQHRKYILQEQLKVIKK---------ELGIEKDDKDAI 458
            ||.||.:::|..:|.||     ..|::....|.:|.     |:|         .|..|.:|:|:.
Zfish   214 ALPLLTRQIEGLKLLQK-----TRKLRPDDDKRVLS-----IRKGGVFPGRQFSLDEEVEDEDSD 268

  Fly   459 GEKYRE-KLKDKVVPEAIMTVIDEELTKLNFLESHSSEFNVTRNYLDWLTSLPWGVISTENLCLE 522
            .....| |:|...:|||.:.|..:||.:|..:.....|:.:|||||:.:..|||...:|:.|.:.
Zfish   269 DTALLERKVKAAAMPEAALRVCLKELRRLKKMPQSMPEYALTRNYLEMMVELPWSKSTTDCLDIR 333

  Fly   523 KATETLNDDHYGMEDIKKRILEFIAVSSLKGSTQGKILCFHGPPGVGKTSIAKSIARALNREYFR 587
            .|...|::|||.||.:|||:||::||..||.:.:|.||||.|||||||||:.:||||.|.||:.|
Zfish   334 AARVLLDNDHYAMEKLKKRVLEYLAVRQLKSTLKGPILCFVGPPGVGKTSVGRSIARTLGREFHR 398

  Fly   588 FSVGGMTDVAEIKGHRRTYVGAMPGKLIQCLKKTKIENPLVLIDEVDKIGKGYQGDPSSALLELL 652
            .::||:.|.::|:||||||||:|||::|..||...:.||:.|:|||||:||..||||::||||:|
Zfish   399 IALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVL 463

  Fly   653 DPEQNANFLDHYLDVPVDLSRVLFICTANVIDTIPEPLRDRMELIEMSGYVAEEKIAIARQYLMP 717
            |||||.:|.||||:||.|||:||||.|||...|||..|.||||::::.||..|||:.||.::|:|
Zfish   464 DPEQNHSFTDHYLNVPFDLSQVLFIATANTTATIPPALLDRMEVLQVPGYTQEEKVEIAHRHLIP 528

  Fly   718 QAMKDCGLTDKHINISEDALNMLIRSYCRESGVRNLQKHIEKVIRKVAFRVVKKEG--------- 773
            ..::..|||.:.:.|.:|....:|..|.||:|||:|::.|..|.|.||.:|.  ||
Zfish   529 HQLEQHGLTPQQLQIPQDTTLQIISKYTREAGVRSLERKIGAVCRAVAVKVA--EGQKVSRSEAP 591

  Fly   774 --EHFPVNADN---------------------LTTFLGKQIFSSDRMYATTPVGVVMGLAWTAMG 815
              :|...|.|:                     |...||..:|..:.....|..||.:|||||.||
Zfish   592 TEQHAEQNTDSKVEDSGIAAPPEMPIVIDHVALKDILGPPLFEMEVSERLTLPGVAIGLAWTPMG 656

  Fly   816 GSSLYIETSRRHIRQGAKTDPNTVAGSLHITGNLGDVMKESAQIALTVARN--FLYSLEPNNL-F 877
            |..:::|.||   .:|        .|.|.:||.|||||||||.:|::..|:  ..|.|...:. .
Zfish   657 GEIMFVEASR---MEG--------EGQLTLTGQLGDVMKESAHLAISWLRSNAKTYLLNDGSADL 710

  Fly   878 LEQEHIHLHVPEGATPKDGPSAGITIITALVSLATGKPVRQDIAMTGEVSLKGKVLPVGGIKEKT 942
            ||...||||.|.||..|||||||:||:|.|.||.:|:.||.|:|||||::|:|.||||||||:|.
Zfish   711 LEGTDIHLHFPAGAVTKDGPSAGVTIVTCLASLLSGRLVRSDVAMTGEITLRGLVLPVGGIKDKV 775

  Fly   943 IAARRSGVNCLILPVDNKKDFEELPTYITDGLEVHFATTYEDVYKIAFTDVTETTTNNVEEQEPL 1007
            :||.|:.:..:|:|..|:||.||:|..:...|:...|.|.::|...||.....:..|:   .:.|
Zfish   776 LAAHRANLKRIIIPKRNEKDLEEIPANVRADLDFVLAGTLDEVLNAAFDGGFPSAVNH---PQVL 837

  Fly  1008 QKL 1010
            .||
Zfish   838 SKL 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lon	NP_730435.2	LON	93..>148	CDD:197740	14/58 (24%)
		lon	95..990	CDD:273258	322/946 (34%)
		P-loop_NTPase	530..>581	CDD:304359	32/50 (64%)
		AAA	560..702	CDD:278434	87/141 (62%)
		ChlI	778..991	CDD:304493	96/236 (41%)
lonp2	NP_001008573.1	Lon	4..826	CDD:223542	325/959 (34%)
		LON	9..225	CDD:271862	59/333 (18%)
		AAA	371..513	CDD:278434	87/141 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..606		3/22 (14%)
		ChlI	618..825	CDD:304493	95/217 (44%)
		Microbody targeting signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03121	838..840		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D157119at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100411
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820