DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lon and Lonp2

DIOPT Version :9

Sequence 1:	NP_730435.2	Gene:	Lon / 40138	FlyBaseID:	FBgn0036892	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	XP_006255300.1	Gene:	Lonp2 / 291922	RGDID:	1305466	Length:	852	Species:	Rattus norvegicus

Alignment Length:	837	Identity:	298/837 - (35%)
Similarity:	459/837 - (54%)	Gaps:	115/837 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 IPRSRTGKSRESAAAEELIQNQTLEPPLKSGKVESSSL------PKPPTEEKIVEP--ETG---- 296
            :|.|....|.::|...:|::::.    ||...::|:.|      |.|.::.:.:.|  ..|
  Rat    24 LPGSTMRTSVDTARNLQLVRSRL----LKGTSLQSTILGVIPNTPDPASDSQDLPPLHRIGTAAL 84

  Fly   297 AKENVNQSAPSAQPVLIVE-------VENVKQPIY--KQTEEVKALTQ--EIIKTLRDIITMN-P 349
            |.:.|..:.|.....|::.       |:.:|:..|  .:.|::..|.:  ...||..::..:: .
  Rat    85 AVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNTCKTREELGELSEQ 149

  Fly   350 LYRESLQ--QMLHQN-------QRVVDN--PIYLCDLGASLSAGEPAELQKILEETDIPERLQLA 403
            .||.|:|  :||..:       :|::|:  ...|.|:..|:......|..:||:...:.:|.::.
  Rat   150 FYRYSVQLVEMLDMSVPAVAKLRRLLDSLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMT 214

  Fly   404 LTLLKKELELSRLQQKIGREVEEKVKQQHRKYILQEQLKVIKKELGI--------EKDDKDAIGE 460
            :.||.:::|..:|.||     ..|.||...|.::  .::.|::...|        |::|.|.| .
  Rat   215 IPLLVRQIEGLKLLQK-----TRKPKQDDDKRVI--AIRPIRRITHIPGALEDEEEEEDNDDI-V 271

  Fly   461 KYREKLKDKVVPEAIMTVIDEELTKLNFLESHSSEFNVTRNYLDWLTSLPWGVISTENLCLEKAT 525
            ...:|::...:||....|..:|:.:|..:.....|:.:|||||:.:..|||...:|:.|.:..|.
  Rat   272 MLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAAR 336

  Fly   526 ETLNDDHYGMEDIKKRILEFIAVSSLKGSTQGKILCFHGPPGVGKTSIAKSIARALNREYFRFSV 590
            ..|::|||.||.:|:|:||::||..||.:.:|.||||.|||||||||:.:|:|:.|.||:.|.::
  Rat   337 ILLDNDHYAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIAL 401

  Fly   591 GGMTDVAEIKGHRRTYVGAMPGKLIQCLKKTKIENPLVLIDEVDKIGKGYQGDPSSALLELLDPE 655
            ||:.|.::|:||||||||:|||::|..||...:.||:.|:|||||:||..||||::||||:||||
  Rat   402 GGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPE 466

  Fly   656 QNANFLDHYLDVPVDLSRVLFICTANVIDTIPEPLRDRMELIEMSGYVAEEKIAIARQYLMPQAM 720
            ||.||.||||:|..|||:||||.|||...|||..|.||||:|::.||..||||.||.::|:|:.:
  Rat   467 QNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQL 531

  Fly   721 KDCGLTDKHINISEDALNMLIRSYCRESGVRNLQKHIEKVIRKVAFRVVKKEGEH---------- 775
            :..|||.:.|.|.:.....:|..|.||:|||:|.:....:.|.||.:|.  ||:|
  Rat   532 EQHGLTPQQIQIPQLTTLAIITRYTREAGVRSLDRKFGAICRAVAVKVA--EGQHKEAKLDRSDV 594

  Fly   776 ------------------------------FPVNADN--LTTFLGKQIFSSDRMYATTPVGVVMG 808
                                          .|:..|:  |...||..::..:.....:..||.:|
  Rat   595 ADGEGCKEHVLEDAKPESIGDAADLALPPEMPILIDSHALKDILGPPLYELEVSERLSQPGVAIG 659

  Fly   809 LAWTAMGGSSLYIETSRRHIRQGAKTDPNTVAGSLHITGNLGDVMKESAQIALTVARNFLYSLEP 873
            ||||.:||..:::|.||   ..|        .|.|.:||.|||||||||.:|::..|:.......
  Rat   660 LAWTPLGGKIMFVEASR---MDG--------EGQLTLTGQLGDVMKESAHLAISWLRSNAKKYHL 713

  Fly   874 NNLF-----LEQEHIHLHVPEGATPKDGPSAGITIITALVSLATGKPVRQDIAMTGEVSLKGKVL 933
            .|.|     |:...||||.|.||..|||||||:||:|.|.||.:|:.||.|:|||||::|:|.||
  Rat   714 TNAFGSFDLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVL 778

  Fly   934 PVGGIKEKTIAARRSGVNCLILPVDNKKDFEELPTYITDGLEVHFATTYEDVYKIAF 990
            ||||||:|.:||.|:|:..:|:|..|:||.||:|:.:...|....|:..::|...||
  Rat   779 PVGGIKDKVLAAHRAGLKHIIIPQRNEKDLEEIPSNVKQDLSFVTASCLDEVLNAAF 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lon	NP_730435.2	LON	93..>148	CDD:197740
		lon	95..990	CDD:273258	296/835 (35%)
		P-loop_NTPase	530..>581	CDD:304359	29/50 (58%)
		AAA	560..702	CDD:278434	86/141 (61%)
		ChlI	778..991	CDD:304493	92/220 (42%)
Lonp2	XP_006255300.1	LON	9..210	CDD:271862	38/189 (20%)
		Lon	11..838	CDD:223542	298/837 (36%)
		AAA	371..513	CDD:278434	86/141 (61%)
		ChlI	629..837	CDD:304493	92/218 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0466
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D157119at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100411
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720