DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lon and lonp-1

DIOPT Version :9

Sequence 1:	NP_730435.2	Gene:	Lon / 40138	FlyBaseID:	FBgn0036892	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	NP_492796.1	Gene:	lonp-1 / 172966	WormBaseID:	WBGene00016391	Length:	971	Species:	Caenorhabditis elegans

Alignment Length:	1042	Identity:	500/1042 - (47%)
Similarity:	661/1042 - (63%)	Gaps:	131/1042 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLARAIRVRPMMRGIASSSVWNRNRPIQSSLMQYCRDRSLRLQRLHGANLMVQRFYSRKRDDSNG 65
            :|..|.|.|.:....|..|....::..||.||.    :|:.|    ..|...:||||...|
Worm     8 LLRGATRTRLLAAASAHQSFATFSQRNQSILMM----KSMEL----AGNSGERRFYSTHDD---- 60

  Fly    66 DIIMGPDLMSDQDTHLPATVAVPDVWPHVPLLAMRKNPLFPRFMKIVE-VSNPIIMDLLRRKVKL 129
            .|.:...|...:|....:.:.||...|:||:||:.:.||||.|:|.|: |.:..:..|:||::.|
Worm    61 PIAVDDSLELYKDLGGMSPIQVPADMPNVPMLAINRYPLFPGFIKKVDIVKDDNLKALIRRQLSL 125

  Fly   130 NQPYVGVFLKKTD-GEEELITNLNDVYNLGTFAQIQELQDLGDKLRMVVVAHRRIRITGQVVEDV 193
            .|||.|||:|:.| .:||.||:|::||..|:|.||.|::|.|..|.:|:.||||||    .:|.:
Worm   126 KQPYAGVFVKRDDENKEETITSLSEVYPTGSFVQIIEVRDQGSVLELVLSAHRRIR----ALEPI 186

  Fly   194 PPPKPVKMTTLHYPLFNIKLQIPAEDQSTDQADAAPIKSRSDPARKPRGRIPRSRTGKSRESAAA 258
            ....|...|.|:                               .|:.||:...|.|
Worm   187 DEITPKNETPLN-------------------------------GRRARGKRAASAT--------- 211

  Fly   259 EELIQNQTLEPPLKSGKVESSSLPKPP---TEEKIVEPETGAKENVNQ--SAPSA------QPVL 312
                  ..|.||           |.||   .....|.||..|.|...:  :.|||      :.::
Worm   212 ------SPLTPP-----------PSPPPLAPSVASVAPEISATEEKEEKTTPPSATGEKQKKGII 259

  Fly   313 IVEVEN-VKQPIYKQTEEVKALTQEIIKTLRDIITMNPLYRESLQQMLHQNQRVVDNPIYLCDLG 376
            :|..|| |.:|:.| ..|.||....|::|:||::..|.|:.:.:..:||.:|.|:|||:|||||.
Worm   260 MVRTENVVAEPVPK-NNETKATMMAIVQTIRDVVQFNQLFGQQINLLLHPSQNVIDNPVYLCDLV 323

  Fly   377 ASL-SAGEPAELQKILEETDIPERLQLALTLLKKELELSRLQQKIGREVEEKVKQQHRKYILQEQ 440
            |:| .:.|..:||::::|.|:.:||::||.|::||..:::|:..|.::||:||:..||||:|.||
Worm   324 ATLVQSAETKDLQEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHHRKYLLNEQ 388

  Fly   441 LKVIKKELGIEKDDKDAIGEKYREKLKDKVVPEAIMTVIDEELTKLNFLESHSSEFNVTRNYLDW 505
            |||||||||||||:|..|.||..|::|...|||..:.||:||.|||.||:.|||||:||||||:|
Worm   389 LKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEW 453

  Fly   506 LTSLPWGVISTENLCLEKATETLNDDHYGMEDIKKRILEFIAVSSLKGSTQGKILCFHGPPGVGK 570
            |||:|||:.|.||..|..|.:.|::.||||:|:|:||:|||||:.|:.|..||||||||||||||
Worm   454 LTSVPWGLTSPENRRLSVAKKALDEGHYGMKDVKERIMEFIAVNLLRKSIGGKILCFHGPPGVGK 518

  Fly   571 TSIAKSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKLIQCLKKTKIENPLVLIDEVDK 635
            ||||||||.||||||||||||||||||||||||||||||||||:|||:||.|.||||||||||||
Worm   519 TSIAKSIATALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKMIQCMKKVKTENPLVLIDEVDK 583

  Fly   636 I-GKGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSRVLFICTANVIDTIPEPLRDRMELIEM 699
            | |.|:.|||:|||||||||||||||.||:|||||||||||||||||.|..||.|||||||:|::
Worm   584 IGGAGFHGDPASALLELLDPEQNANFNDHFLDVPVDLSRVLFICTANEISKIPGPLRDRMEMIDV 648

  Fly   700 SGYVAEEKIAIARQYLMPQAMKDCGLTDKHINISEDALNMLIRSYCRESGVRNLQKHIEKVIRKV 764
            |||:||||:.||.|:|:||..||..|..:.:.|.:.||..||:.|||||||||||:|||::.||.
Worm   649 SGYLAEEKVEIAHQHLIPQLRKDTSLATEQLKIEDSALEELIKHYCRESGVRNLQQHIERIFRKA 713

  Fly   765 AFRV-----------------------------------VKKEGEHFPVNADNLTTFLGKQIFSS 794
            |.::                                   :|...|...|..:||..|:|:..|:|
Worm   714 ALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTS 778

  Fly   795 DRMYATTPVGVVMGLAWTAMGGSSLYIETSRRHIRQGAKTD-PNTVAGSLHITGNLGDVMKESAQ 858
            ||||..||.||:|||||||||||:|||||..:.     ..| .|...||:..|||||||||||.:
Worm   779 DRMYEVTPPGVIMGLAWTAMGGSALYIETVLKR-----PVDLTNDKDGSIETTGNLGDVMKESVR 838

  Fly   859 IALTVARNFLYSLEPNNLFLEQEHIHLHVPEGATPKDGPSAGITIITALVSLATGKPVRQDIAMT 923
            .|||||:..|...:|:|.|.::.|||:|||||||||||||||:|::::|:|||..:||.||:|||
Worm   839 TALTVAKGILAREQPDNKFFDKAHIHIHVPEGATPKDGPSAGVTLVSSLLSLALDRPVVQDMAMT 903

  Fly   924 GEVSLKGKVLPVGGIKEKTIAARRSGVNCLILPVDNKKDFEELPTYITDGLEVHFATTYEDVYKI 988
            ||:||.|||||||||:||.|||||.|...:.||.:|::||::||.::...|::.|.:.|:::|:.
Worm   904 GEISLTGKVLPVGGIREKVIAARRVGAKRVFLPNENRRDFDDLPEFMKSELDIRFVSHYDELYEH 968

  Fly   989 AF 990
            .|
Worm   969 LF 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lon	NP_730435.2	LON	93..>148	CDD:197740	26/56 (46%)
		lon	95..990	CDD:273258	474/946 (50%)
		P-loop_NTPase	530..>581	CDD:304359	37/50 (74%)
		AAA	560..702	CDD:278434	123/142 (87%)
		ChlI	778..991	CDD:304493	118/214 (55%)
lonp-1	NP_492796.1	LON	89..>151	CDD:197740	29/61 (48%)
		lon	90..970	CDD:273258	474/946 (50%)
		P-loop_NTPase	465..>531	CDD:304359	44/65 (68%)
		AAA	508..646	CDD:278434	121/137 (88%)
		ChlI	761..970	CDD:304493	117/213 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158357
Domainoid	1	1.000	245	1.000	Domainoid score	I1217
eggNOG	1	0.900	-	-		E1_COG0466
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3521
Inparanoid	1	1.050	877	1.000	Inparanoid score	I204
Isobase	1	0.950	-	0	Normalized mean entropy	S666
OMA	1	1.010	-	-		QHG55281
OrthoDB	1	1.010	-	-		D157119at33208
OrthoFinder	1	1.000	-	-		FOG0002884
OrthoInspector	1	1.000	-	-		oto18443
orthoMCL	1	0.900	-	-		OOG6_100411
Panther	1	1.100	-	-	LDO	PTHR43718
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R662
SonicParanoid	1	1.000	-	-		X2242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790