DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lon and Lonp1

DIOPT Version :9

Sequence 1:	NP_730435.2	Gene:	Lon / 40138	FlyBaseID:	FBgn0036892	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	NP_596895.1	Gene:	Lonp1 / 170916	RGDID:	621598	Length:	950	Species:	Rattus norvegicus

Alignment Length:	941	Identity:	575/941 - (61%)
Similarity:	699/941 - (74%)	Gaps:	98/941 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 ATVAVPDVWPHVPLLAMRKNPLFPRFMKIVEVSNPIIMDLLRRKVKLNQPYVGVFLKKTD-GEEE 146
            |.:.||||:||:||:|:.:||:||||:|||||.|..:::||||||:|.|||||||||:.| .|.:
  Rat   101 APMTVPDVFPHLPLIAISRNPVFPRFIKIVEVKNKKLVELLRRKVRLAQPYVGVFLKRDDNNESD 165

  Fly   147 LITNLNDVYNLGTFAQIQELQDLGDKLRMVVVAHRRIRITGQVVEDVPPPKPVKMTTLHYPLFNI 211
            ::.:|:::|:.||||||.|:|||||||||:|..||||.|:.|:  :|.|.
  Rat   166 VVESLDEIYHTGTFAQIHEMQDLGDKLRMIVTGHRRIHISRQL--EVEPE--------------- 213

  Fly   212 KLQIPAEDQSTDQADAAPIKSRSDPARKPRGRIPRSRTGKSRESAAAEELIQNQTLEPPLKSGKV 276
            .|:..||::.         |||    ||                               ||.||.
  Rat   214 GLEPEAENKQ---------KSR----RK-------------------------------LKRGKK 234

  Fly   277 ESSSLPKPPTEEKIVEPETGAKENVNQ----SAPSAQPVLIVEVENVKQPIYKQTEEVKALTQEI 337
            |             |..|.|||..:..    ::.:::.||:||||||....::.||||||||.||
  Rat   235 E-------------VGDELGAKPQLEMVTEATSDTSKEVLMVEVENVAHEDFQVTEEVKALTAEI 286

  Fly   338 IKTLRDIITMNPLYRESLQQMLHQNQRVVDNPIYLCDLGASLSAGEPAELQKILEETDIPERLQL 402
            :||:||||.:|||||||:.||:...||||||||||.|:||:|:..|..|||.:||||:|.:||..
  Rat   287 VKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNILKRLYK 351

  Fly   403 ALTLLKKELELSRLQQKIGREVEEKVKQQHRKYILQEQLKVIKKELGIEKDDKDAIGEKYREKLK 467
            ||:|||||.|||:|||::|||||||:||.||||:||||||:||||||:||||||||.||:||:||
  Rat   352 ALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLK 416

  Fly   468 DKVVPEAIMTVIDEELTKLNFLESHSSEFNVTRNYLDWLTSLPWGVISTENLCLEKATETLNDDH 532
            :.|||:.:|.|:||||:||..|::|||||||||||||||||:|||..|.|||.|.:|...|.:||
  Rat   417 ELVVPKHVMDVVDEELSKLALLDNHSSEFNVTRNYLDWLTSIPWGRQSDENLDLARAQSVLEEDH 481

  Fly   533 YGMEDIKKRILEFIAVSSLKGSTQGKILCFHGPPGVGKTSIAKSIARALNREYFRFSVGGMTDVA 597
            |||||:|||:|||||||.|:||||||||||||||||||||||:||||||.|||||||||||||||
  Rat   482 YGMEDVKKRVLEFIAVSQLRGSTQGKILCFHGPPGVGKTSIARSIARALGREYFRFSVGGMTDVA 546

  Fly   598 EIKGHRRTYVGAMPGKLIQCLKKTKIENPLVLIDEVDKIGKGYQGDPSSALLELLDPEQNANFLD 662
            ||||||||||||||||:||||||||.||||||||||||||:||||||||||||||||||||||||
  Rat   547 EIKGHRRTYVGAMPGKIIQCLKKTKTENPLVLIDEVDKIGRGYQGDPSSALLELLDPEQNANFLD 611

  Fly   663 HYLDVPVDLSRVLFICTANVIDTIPEPLRDRMELIEMSGYVAEEKIAIARQYLMPQAMKDCGLTD 727
            ||||||||||:|||||||||.||||||||||||:|.:|||||:||:|||.:||:|||...|||.:
  Rat   612 HYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARTLCGLDE 676

  Fly   728 KHINISEDALNMLIRSYCRESGVRNLQKHIEKVIRKVAFRVVKKEGEHFPVNADNLTTFLGKQIF 792
            ....:|...|.:||:.||||||||||||.:|||:||.|:::|..|.:...|..:||..|:||.:|
  Rat   677 SKAQLSATVLTLLIKQYCRESGVRNLQKQVEKVLRKAAYKIVSGEAQTVHVTPENLQDFVGKPVF 741

  Fly   793 SSDRMYATTPVGVVMGLAWTAMGGSSLYIETS-RRHIRQGAKTDPNTVAGSLHITGNLGDVMKES 856
            :.:|||..||.||||||||||||||:|::||| ||....|:|.|.:   |||.:||.||||||||
  Rat   742 TVERMYDVTPPGVVMGLAWTAMGGSTLFVETSLRRPQPSGSKEDKD---GSLEVTGQLGDVMKES 803

  Fly   857 AQIALTVARNFLYSLEPNNLFLEQEHIHLHVPEGATPKDGPSAGITIITALVSLATGKPVRQDIA 921
            |:||.|.||.||...:|.|.||...|||||||||||||||||||.||:|||:|||.|:||.|::|
  Rat   804 ARIAYTFARAFLMEQDPENDFLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLALGQPVLQNLA 868

  Fly   922 MTGEVSLKGKVLPVGGIKEKTIAARRSGVNCLILPVDNKKDFEELPTYITDGLEVHFATTYEDVY 986
            |||||||.||||||||||||||||:|:||.|:|||.:|:|||.:|..:||:||||||...|.|::
  Rat   869 MTGEVSLTGKVLPVGGIKEKTIAAKRAGVTCIILPAENRKDFSDLAPFITEGLEVHFVEHYRDIF 933

  Fly   987 KIAFTDVTETTTNNVEEQEPLQKLSSAAAAK 1017
            :|||               ||::...|.|.:
  Rat   934 RIAF---------------PLREHQEALAVE 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lon	NP_730435.2	LON	93..>148	CDD:197740	34/55 (62%)
		lon	95..990	CDD:273258	562/900 (62%)
		P-loop_NTPase	530..>581	CDD:304359	44/50 (88%)
		AAA	560..702	CDD:278434	131/141 (93%)
		ChlI	778..991	CDD:304493	139/213 (65%)
Lonp1	NP_596895.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..94
		LON	111..188	CDD:197740	44/76 (58%)
		lon	113..937	CDD:273258	562/900 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..243		17/102 (17%)
		P-loop_NTPase	479..>530	CDD:304359	44/50 (88%)
		AAA	509..651	CDD:278434	131/141 (93%)
		ChlI	727..938	CDD:304493	140/228 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338402
Domainoid	1	1.000	278	1.000	Domainoid score	I1641
eggNOG	1	0.900	-	-		E1_COG0466
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3521
Inparanoid	1	1.050	1084	1.000	Inparanoid score	I227
OMA	1	1.010	-	-		QHG55281
OrthoDB	1	1.010	-	-		D157119at33208
OrthoFinder	1	1.000	-	-		FOG0002884
OrthoInspector	1	1.000	-	-		oto98818
orthoMCL	1	0.900	-	-		OOG6_100411
Panther	1	1.100	-	-	LDO	PTHR43718
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810