DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lon and lonp2

DIOPT Version :9

Sequence 1:	NP_730435.2	Gene:	Lon / 40138	FlyBaseID:	FBgn0036892	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	XP_031756683.1	Gene:	lonp2 / 100145688	XenbaseID:	XB-GENE-948726	Length:	856	Species:	Xenopus tropicalis

Alignment Length:	837	Identity:	307/837 - (36%)
Similarity:	446/837 - (53%)	Gaps:	111/837 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 IPRSRTGKSRESAAAEELIQNQTLE-PPLKS---GKVESSSLPKPPTEEKIVEPETG----AKEN 300
            :|.|....|.::....||::|:.|. ..|||   |.|.::|.|....||.......|    |.:.
Frog    24 LPGSSMRTSVDTPGNMELVRNRLLRGTSLKSTIIGVVPNTSDPSSDREELPSLHRIGTAALAVQV 88

  Fly   301 VNQSAPSAQPVL---------IVEVENVKQPIYKQTEEVKALTQ-----EIIKTLRDIITMNPLY 351
            |..:.|.....|         |:||...:.....:.|::..|.|     |..:.|.|:......|
Frog    89 VGSNWPKPHYTLLVTGLCRFQIIEVRKERPYPVAEVEQLDRLEQLSSKEEFKEALGDLSEQFYKY 153

  Fly   352 RESLQQMLHQN-------QRVVDN-PIYLC-DLGASLSAGEPAELQKILEETDIPERLQLALTLL 407
            ...|..||..:       :|:::| |..|. |:..|:......|..:||:...:.||.::.:.||
Frog   154 AVQLVDMLDNSVPAVAKLKRLLNNLPRELLPDVLTSIIRTTNEEKLQILDAVSLEERFKVTIPLL 218

  Fly   408 KKELELSRLQQKIGREVEEKVKQQHRKYIL-----QEQLKVIKKELGIEK---DDKDA----IGE 460
            .:::|..:|.||     ....||...|.|:     ::...|..|...:|.   ||:|:    |.|
Frog   219 LRQIEGLKLLQK-----TRNPKQDDDKRIVAIRPPRKLGNVSGKSFSLENTDDDDEDSDDIIILE 278

  Fly   461 KYREKLKDKVVPEAIMTVIDEELTKLNFLESHSSEFNVTRNYLDWLTSLPWGVISTENLCLEKAT 525
            |   |:|...:||..:.|..:|:.:|..:.....|:.:|||||:.::.|||...:.:.|.:..|.
Frog   279 K---KIKSSNMPEPALKVCVKEIKRLKKMPQSMPEYALTRNYLELMSELPWSKATRDRLDIRAAR 340

  Fly   526 ETLNDDHYGMEDIKKRILEFIAVSSLKGSTQGKILCFHGPPGVGKTSIAKSIARALNREYFRFSV 590
            ..|::|||.|..:|||:||::||..||.:.:|.||||.|||||||||:.:|||:.|.||:.|.::
Frog   341 ILLDNDHYAMAKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSIAKTLGREFHRIAL 405

  Fly   591 GGMTDVAEIKGHRRTYVGAMPGKLIQCLKKTKIENPLVLIDEVDKIGKGYQGDPSSALLELLDPE 655
            ||:.|.::|:||||||||:|||::|..||...:.||:.|:|||||:||..||||::||||:||||
Frog   406 GGVCDQSDIRGHRRTYVGSMPGRIINGLKIVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPE 470

  Fly   656 QNANFLDHYLDVPVDLSRVLFICTANVIDTIPEPLRDRMELIEMSGYVAEEKIAIARQYLMPQAM 720
            ||.||.||||:|..|||:||||.|||.|.|||..|.||||:||:.||..|||:.||.::|:.:.:
Frog   471 QNHNFTDHYLNVAFDLSQVLFIATANTISTIPPALLDRMEVIEVPGYSQEEKLEIAHRHLISKQL 535

  Fly   721 KDCGLTDKHINISEDALNMLIRSYCRESGVRNLQKHIEKVIRKVAFRVVKKEGEH---------- 775
            ...|||.:.|.|.::|...:|..|.||:|||:|.:.:..:.|.||.:|.  ||:|
Frog   536 AQHGLTPEQIQIPQEATLEIITRYTREAGVRSLDRKLGAICRAVAVKVA--EGQHREPKSEHLEA 598

  Fly   776 ------------------------------FPVNADN--LTTFLGKQIFSSDRMYATTPVGVVMG 808
                                          .|:..|.  |...||..::..:........||.:|
Frog   599 PEGEERKESIPEGSKSGTIHDTADFALPPEMPILIDRHALKDILGPPMYDIEVFGRLNQPGVAIG 663

  Fly   809 LAWTAMGGSSLYIETSRRHIRQGAKTDPNTVAGSLHITGNLGDVMKESAQIALTVARNFLYSLEP 873
            ||||.:||..:::|.||   ..|        .|.|.:||.|||||||||.:|::..|:.....:.
Frog   664 LAWTPLGGEIMFVEASR---MDG--------EGQLTLTGQLGDVMKESAHLAISWLRSHAKKYQL 717

  Fly   874 NNL-----FLEQEHIHLHVPEGATPKDGPSAGITIITALVSLATGKPVRQDIAMTGEVSLKGKVL 933
            .|.     .|:...||||.|.||..|||||||:.|:|.|.||.:|:.|..|:|||||::|:|.||
Frog   718 TNASGSFDLLDNTDIHLHFPAGAVTKDGPSAGVAIVTCLASLFSGRLVCSDVAMTGEITLRGLVL 782

  Fly   934 PVGGIKEKTIAARRSGVNCLILPVDNKKDFEELPTYITDGLEVHFATTYEDVYKIAF 990
            ||||||:|.:||.|:|:..:|||..|:.|.||:|..:...||...|.:.::|...||
Frog   783 PVGGIKDKVLAAHRAGLKRVILPKRNETDLEEIPLNVRQDLEFVLAGSLDEVLNAAF 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lon	NP_730435.2	LON	93..>148	CDD:197740
		lon	95..990	CDD:273258	305/835 (37%)
		P-loop_NTPase	530..>581	CDD:304359	30/50 (60%)
		AAA	560..702	CDD:278434	89/141 (63%)
		ChlI	778..991	CDD:304493	90/220 (41%)
lonp2	XP_031756683.1	Lon	12..842	CDD:223542	307/837 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D157119at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920