DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9372 and PRSS8

DIOPT Version :9

Sequence 1:	NP_649132.1	Gene:	CG9372 / 40137	FlyBaseID:	FBgn0036891	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_002764.1	Gene:	PRSS8 / 5652	HGNCID:	9491	Length:	343	Species:	Homo sapiens

Alignment Length:	275	Identity:	92/275 - (33%)
Similarity:	140/275 - (50%)	Gaps:	39/275 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 TSADGDEPRIVNKPEQRGCGITSRQFPRLTGGRPAEPDEWPWMAALLQEGLPFVWCGGVLITDRH 210
            |.|:|.|         ..||:..:  .|:|||..|...:|||..::..||:..  |||.|::::.
Human    28 TGAEGAE---------APCGVAPQ--ARITGGSSAVAGQWPWQVSITYEGVHV--CGGSLVSEQW 79

  Fly   211 VLTAAHCI-YKKNKEDIFVRLGEYNTHMLNETRARDFRIANMVLHIDYNPQNYDNDIAIVRIDRA 274
            ||:||||. .:.:||...|:||.:.....:|. |:...:.:::.|..|..:....|||::::.|.
Human    80 VLSAAHCFPSEHHKEAYEVKLGAHQLDSYSED-AKVSTLKDIIPHPSYLQEGSQGDIALLQLSRP 143

  Fly   275 TIFNTYIWPVCMPPVNEDW-SDRNAIVTGWGTQKFGGPHSNI-----LMEVNLPVWKQSDC---- 329
            ..|:.||.|:|:|..|..: :..:..|||||   ...|..::     |.::.:|:..:..|
Human   144 ITFSRYIRPICLPAANASFPNGLHCTVTGWG---HVAPSVSLLTPKPLQQLEVPLISRETCNCLY 205

  Fly   330 -------RSSFVQHVPDTAMCAGFPEGGQDSCQGDSGGPLLVQLPNQRWVTIGIVSWGVGCGQRG 387
                   ...|||   :..:|||:.|||:|:|||||||||...:.. .|...||||||..||.|.
Human   206 NIDAKPEEPHFVQ---EDMVCAGYVEGGKDACQGDSGGPLSCPVEG-LWYLTGIVSWGDACGARN 266

  Fly   388 RPGIYTRVDRYLDWI 402
            |||:||....|..||
Human   267 RPGVYTLASSYASWI 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9372	NP_649132.1	CLIP	87..132	CDD:197829
		Tryp_SPc	173..402	CDD:214473	84/246 (34%)
		Tryp_SPc	176..402	CDD:238113	82/243 (34%)
PRSS8	NP_002764.1	Tryp_SPc	44..281	CDD:214473	84/246 (34%)
PRSS8	NP_002764.1	Tryp_SPc	45..284	CDD:238113	85/247 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910