DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9372 and KLKB1

DIOPT Version :9

Sequence 1:	NP_649132.1	Gene:	CG9372 / 40137	FlyBaseID:	FBgn0036891	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	423	Identity:	123/423 - (29%)
Similarity:	197/423 - (46%)	Gaps:	57/423 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PQSTIAKTVSTDFLDLLDFSDNDEFQWGESENQVYENRTGENRVVS-------FLSQHRL--NKR 71
            |.:.:.:|:.|...:.|.|:........||:..|...:|.|:...|       .:|.:.|  .||
Human   233 PDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKR 297

  Fly    72 QAPT---SQLLENKDYG-------------ACSTPLGESGRCRHIIYCRMPE-LKNDVWRLVSQL 119
            ..|.   |::....|:|             .|.....:..||:...|..:|| .|.:..:
Human   298 TLPEPCHSKIYPGVDFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCK----- 357

  Fly   120 CIIEKSSIGICCTDQSTSNRFSPQVVTSADGDEPRIVNKPEQRGCGITSRQFPRLTGGRPAEPDE 184
            |.:..|..|     ..|...:..|   .:.|...|:.|..:...|  |::...|:.||..:...|
Human   358 CFLRLSMDG-----SPTRIAYGTQ---GSSGYSLRLCNTGDNSVC--TTKTSTRIVGGTNSSWGE 412

  Fly   185 WPWMAAL-----LQEGLPFVWCGGVLITDRHVLTAAHCIYKKNKEDIFVRLGEYNTHMLNETRAR 244
            |||..:|     .|..|    |||.||..:.|||||||......:|:: |:.....::.:.|:..
Human   413 WPWQVSLQVKLTAQRHL----CGGSLIGHQWVLTAAHCFDGLPLQDVW-RIYSGILNLSDITKDT 472

  Fly   245 DF-RIANMVLHIDYNPQNYDNDIAIVRIDRATIFNTYIWPVCMPPVNEDWSD--RNAIVTGWGTQ 306
            .| :|..:::|.:|.....::|||::::.....:..:..|:|:|. ..|.|.  .|..|||||..
Human   473 PFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPS-KGDTSTIYTNCWVTGWGFS 536

  Fly   307 KFGGPHSNILMEVNLPVWKQSDCRSSFVQH-VPDTAMCAGFPEGGQDSCQGDSGGPLLVQLPNQR 370
            |..|...|||.:||:|:....:|:..:..: :....:|||:.|||:|:|:|||||||:.: .|..
Human   537 KEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCK-HNGM 600

  Fly   371 WVTIGIVSWGVGCGQRGRPGIYTRVDRYLDWIL 403
            |..:||.|||.||.:|.:||:||:|..|:||||
Human   601 WRLVGITSWGEGCARREQPGVYTKVAEYMDWIL 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9372	NP_649132.1	CLIP	87..132	CDD:197829	10/45 (22%)
		Tryp_SPc	173..402	CDD:214473	84/237 (35%)
		Tryp_SPc	176..402	CDD:238113	83/234 (35%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519	13/61 (21%)
		APPLE	303..386	CDD:128519	17/95 (18%)
		Tryp_SPc	401..632	CDD:214473	84/237 (35%)
		Tryp_SPc	402..632	CDD:238113	83/236 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42230
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910