DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9372 and Prss12

DIOPT Version :9

Sequence 1:	NP_649132.1	Gene:	CG9372 / 40137	FlyBaseID:	FBgn0036891	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_032965.1	Gene:	Prss12 / 19142	MGIID:	1100881	Length:	761	Species:	Mus musculus

Alignment Length:	296	Identity:	94/296 - (31%)
Similarity:	150/296 - (50%)	Gaps:	43/296 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 GICC--TDQSTSNRFSPQVVTSADGDEPRIVNKPEQRGCG--ITSRQFPRLTGGRPAEPDEWPWM 188
            |:.|  .::..|:..:.::::|               |||  :..|:..|:.||..:....|||.
Mouse   482 GVICDYLEKKASSSGNKEMLSS---------------GCGLRLLHRRQKRIIGGNNSLRGAWPWQ 531

  Fly   189 AAL---LQEGLPFVWCGGVLITDRHVLTAAHCI--YKKNKEDIFVRLGEYNTHMLNETRARDFRI 248
            |:|   ...|...:.||..|::...|||||||.  |..|.....||:|:|:| ::.|...::..:
Mouse   532 ASLRLRSAHGDGRLLCGATLLSSCWVLTAAHCFKRYGNNSRSYAVRVGDYHT-LVPEEFEQEIGV 595

  Fly   249 ANMVLHIDYNPQNYDNDIAIVRI----DRATIFNTYIWPVCMPPVNEDWSDR------NAIVTGW 303
            ..:|:|.:|.|...|.|||:||:    ::....:|::.|.|:|.    |.:|      |..:|||
Mouse   596 QQIVIHRNYRPDRSDYDIALVRLQGPGEQCARLSTHVLPACLPL----WRERPQKTASNCHITGW 656

  Fly   304 GTQKFGGPHSNILMEVNLPVWKQSDCRSSFVQHVPDTAMCAG-FPEGGQ-DSCQGDSGGPLLVQL 366
            |..  |..:|..|.:..:|:..:..|:..:........:||| ..|..: |||||||||||:.:.
Mouse   657 GDT--GRAYSRTLQQAAVPLLPKRFCKERYKGLFTGRMLCAGNLQEDNRVDSCQGDSGGPLMCEK 719

  Fly   367 PNQRWVTIGIVSWGVGCGQRGRPGIYTRVDRYLDWI 402
            |::.||..|:.|||.|||.:..||:||||..::.||
Mouse   720 PDESWVVYGVTSWGYGCGVKDTPGVYTRVPAFVPWI 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9372	NP_649132.1	CLIP	87..132	CDD:197829	2/5 (40%)
		Tryp_SPc	173..402	CDD:214473	84/245 (34%)
		Tryp_SPc	176..402	CDD:238113	83/242 (34%)
Prss12	NP_032965.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..87
		KR	83..159	CDD:214527
		SR	166..265	CDD:214555
		SRCR	171..265	CDD:278931
		SR	273..372	CDD:214555
		SRCR	278..371	CDD:278931
		SR	386..485	CDD:214555	1/2 (50%)
		SRCR	396..485	CDD:278931	1/2 (50%)
		Zymogen activation region	505..516		3/10 (30%)
		Tryp_SPc	516..755	CDD:214473	84/245 (34%)
		Tryp_SPc	517..758	CDD:238113	85/246 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6614
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860