DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf6 and taf6

DIOPT Version :9

Sequence 1:	NP_524161.2	Gene:	Taf6 / 40134	FlyBaseID:	FBgn0010417	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001004557.1	Gene:	taf6 / 447818	ZFINID:	ZDB-GENE-040912-23	Length:	636	Species:	Danio rerio

Alignment Length:	627	Identity:	290/627 - (46%)
Similarity:	402/627 - (64%)	Gaps:	64/627 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ISAESMKVIAESIGVGSLSDDAAKELAEDVSIKLKRIVQDAAKFMNHAKRQKLSVRDIDMSLKVR 85
            :..:|||.:|||:|:|||.:|:...|:|:||.::|.|.|||.|||:|.||.||:..|||.:||::
Zfish    14 LPTDSMKAMAESVGIGSLQEDSCLTLSEEVSYRIKEIAQDALKFMHHGKRCKLTTGDIDHALKLK 78

  Fly    86 NVEPQYGFVAKDFIPFRFASGGGRELHFTEDKEIDLGEITSTNSVKIPLDLTLRSHWFVVEGVQP 150
            ||||.|||.:::||||||||||||||||.|:||:||.:|.:|...::|||::|::||..::||||
Zfish    79 NVEPLYGFQSEEFIPFRFASGGGRELHFYEEKEVDLSDIINTPLPRVPLDVSLKAHWLSIDGVQP 143

  Fly   151 TVPENPPPLSKDSQLLDSVNPVIKMDQGLNKD----AAGKPTTGKIHKLKNVETIHVKQLATHEL 211
            .:|||||..||:.|..:|..|:..:..|...:    |.|:.....  ::|..|.:.:|..:||||
Zfish   144 AIPENPPSASKEQQKAESTEPLKAVKPGQEDEGFIQAKGQSAVSA--EVKGKEKMRMKPRSTHEL 206

  Fly   212 SVEQQLYYKEITEACVGSDEPRRGEALQSLGSDPGLHEMLPRMCTFIAEGVKVNVVQNNLALLIY 276
            ||||||||||||||||||.|.:|.|||||:.:||||::||||..|||:|||:|||||||||||||
Zfish   207 SVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIY 271

  Fly   277 LMRMVRALLDNPSLFLEKYLHELIPSVMTCIVSKQLCMRPELDNHWALRDFASRLMAQICKNFNT 341
            |||||:||:|||:|:||||||||||:|:|||||||||:||::||||||||||:|||||.||.|:|
Zfish   272 LMRMVKALMDNPTLYLEKYLHELIPAVVTCIVSKQLCLRPDVDNHWALRDFAARLMAQSCKTFST 336

  Fly   342 LTNNLQTRVTRIFSKALQNDKTHLSSLYGSIAGLSELGGEVIKVFIIPRLKFISERIEPHLLGTS 406
            .|||:|:|:|:.|:|||.::||..::.||.||||:|||.:|||..|||||.....||:..:.|..
Zfish   337 TTNNIQSRITKTFTKALLDEKTQWTTRYGCIAGLAELGHDVIKTLIIPRLFVEGARIKAVMDGPV 401

  Fly   407 ISNTDKTAAGHIRAMLQKCCPPILRQMRSAPDTAEDYKNDFGFLGPSLCQAVVKVRNAPASSIVT 471
            :||.||..|.|::::|.|.|..::.:.|..||..|.||.|:|:||..||..|||.|...|....|
Zfish   402 VSNIDKIGADHVQSLLLKHCASVVAKTRPVPDLVEQYKADYGYLGTMLCSHVVKARAQAAFQAQT 466

  Fly   472 LSSNTINTAPITSAAQTATTIGRVSMPTTQRQGSPGVSSLPQIRAI---------QANQPAQKFV 527
            ::..|:.   ||....| .|:.:..:.|:....:|.:..:|....:         |.:.||.|::
Zfish   467 VNRTTLT---ITQPRPT-LTMSQSGLSTSGVSRTPSIIKVPSSLTLMSTRPGTPTQPSPPATKYI 527

  Fly   528 -------------IVTQNSPQQGQAKVVRRGSSPHS------------------------VVLSA 555
                         ::|.:|.|.|........|:|.|                        :|:|.
Zfish   528 VMATSAGAASTQQVITLSSSQSGSPVTSTVPSTPTSLQPLVKLESGNPGAVGSSRPIQKYIVVSL 592

  Fly   556 ASNAASASNSNS---SSSGSLLAAAQRSSDNVCVIAGSEAPA 594
            .|:::|..|..|   |||.|.:     |.::...:..||:||
Zfish   593 PSSSSSMDNKGSGVLSSSTSPI-----SMESAVKLECSESPA 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf6	NP_524161.2	TAF6	22..383	CDD:173968	218/364 (60%)
taf6	NP_001004557.1	TAF6	15..378	CDD:173968	218/364 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592196
Domainoid	1	1.000	275	1.000	Domainoid score	I1727
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7561
Inparanoid	1	1.050	535	1.000	Inparanoid score	I1166
OMA	1	1.010	-	-		QHG49222
OrthoDB	1	1.010	-	-		D384329at2759
OrthoFinder	1	1.000	-	-		FOG0003125
OrthoInspector	1	1.000	-	-		oto38766
orthoMCL	1	0.900	-	-		OOG6_103103
Panther	1	1.100	-	-	LDO	PTHR10221
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1473
SonicParanoid	1	1.000	-	-		X2507
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940