DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf6 and taf-6.1

DIOPT Version :9

Sequence 1:	NP_524161.2	Gene:	Taf6 / 40134	FlyBaseID:	FBgn0010417	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_493919.1	Gene:	taf-6.1 / 173498	WormBaseID:	WBGene00006387	Length:	470	Species:	Caenorhabditis elegans

Alignment Length:	457	Identity:	118/457 - (25%)
Similarity:	222/457 - (48%)	Gaps:	54/457 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KPSKPSSPSSSMLYGSSISAESMKVIAESIGVGSLSDDAAKELAEDVS-IKLKRIVQDAAKFMNH 67
            :||...:......:.:.|..::   .||.:|:.||:.:|| ||.|.:| .|||.||:.:||:...
Worm     9 RPSPTKTSEEPAAHQTPIFTQT---AAEMLGITSLNTEAA-ELLEFLSREKLKEIVRLSAKWTQK 69

  Fly    68 AKRQKLSVRDID-------------------MSLKVRNVEPQYGFVAKDFIPFRFASGGGRELHF 113
            :.|::::|.|::                   ::|.::.::|..|            :..|.....
Worm    70 SARRRMAVADVEHAIRSTRQCGGLNISSVDTLNLGIQQLQPIQG------------TSTGIYSFL 122

  Fly   114 TEDKEIDLGEITSTNSVKIPLDLTLRSHWFVVEGVQPTVPENPPPLSK-DSQLLDSVNPVIKMDQ 177
            ....::|:.:..:...:|||.||.:.|:..|.|| ||...|....:.: |....:.:.|.: |..
Worm   123 KSSADVDVDKEDTETFIKIPRDLRVISYPLVNEG-QPVQSEYTVNVDEDDGNFFEKIVPEV-MTM 185

  Fly   178 GLNKDAAGKPTTGKIHKLKN-VETIHVKQL-----ATHE-LSVEQQLYYKEITEACVGSDEPRRG 235
            ...|:.....||..:...:: |:|..:.|.     :|.| |:||||::.|:|...|:|.|:.:|.
Worm   186 IPEKNTPSSSTTSSLQMFRDAVKTAKIDQKVGLKPSTIEILTVEQQIFMKDIITVCMGQDDKKRH 250

  Fly   236 EALQSLGSDPGLHEMLPRMCTFIAEGVKVNVVQNNLALLIYLMRMVRALLDNPSLFLEKYLHELI 300
            |||.:|.:|.||...||.:...|.:.:..|:.|..|:|:||..|::|:|..|.:..:...||.::
Worm   251 EALYTLETDAGLQVFLPHLTERICKSISANISQRCLSLIIYAGRVLRSLSHNKACDMTVTLHHVL 315

  Fly   301 PSVMTCIVSKQLCMRPELDNHWALRDFASRLMAQICKNFNTLTNNLQTRVTRIFS---KALQNDK 362
            |::::|.|.:.:|:|||.|||||||||:::.:..:.:: ....::......|:|.   :..::..
Worm   316 PALLSCCVGRNMCLRPETDNHWALRDFSAKTLVGLVRD-QVDKHDAGRTARRLFDFSHRIFRDTG 379

  Fly   363 THLSSLYGSIAGLSE-LGGEVIKVFIIPRLKFISERIEPHL-LGTSI--SNTDKTAAGHIRAMLQ 423
            :..|.:||::..|.| :.|.....:::..|...:.|.:.|: .|:.|  |......|..:...:.
Worm   380 SSFSMIYGTVHILQEFVAGPKKAAWLLTELGETNARCKSHIESGSRIGASQLSIQEAQKLNQQIL 444

  Fly   424 KC 425
            ||
Worm   445 KC 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf6	NP_524161.2	TAF6	22..383	CDD:173968	106/392 (27%)
taf-6.1	NP_493919.1	TAF6	32..404	CDD:227426	106/387 (27%)
		TAF6C	225..446	CDD:381749	64/221 (29%)
		HEAT repeat	228..259	CDD:381749	14/30 (47%)
		HEAT repeat	266..301	CDD:381749	12/34 (35%)
		HEAT repeat	311..354	CDD:381749	18/43 (42%)
		HEAT repeat	360..395	CDD:381749	6/34 (18%)
		HEAT repeat	399..445	CDD:381749	7/45 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I5359
eggNOG	1	0.900	-	-		E1_COG5095
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7561
Inparanoid	1	1.050	144	1.000	Inparanoid score	I3034
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D384329at2759
OrthoFinder	1	1.000	-	-		FOG0003125
OrthoInspector	1	1.000	-	-		otm14794
orthoMCL	1	0.900	-	-		OOG6_103103
Panther	1	1.100	-	-	LDO	PTHR10221
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1473
SonicParanoid	1	1.000	-	-		X2507
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860