DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and SETDB1

DIOPT Version :10

Sequence 1:NP_524160.2 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_001353346.1 Gene:SETDB1 / 9869 HGNCID:10761 Length:1292 Species:Homo sapiens


Alignment Length:1440 Identity:275/1440 - (19%)
Similarity:439/1440 - (30%) Gaps:563/1440 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   489 SADDTVEDQDILQLAGL---SLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVT------- 543
            :|..|||.::|.:|...   .||.|.||...:|.:...|........|:..|:..:|.       
Human    12 AATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVA 76

  Fly   544 -TGQYFGRGGSLSATNPD----NFISKMMNQRKETPAPSKSS----------------------- 580
             ..|.|. ..|.:.||.:    :|.||:..|.:::.:..:||                       
Human    77 HVDQLFD-DASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSGDA 140

  Fly   581 ----CKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSH----------NKSLNIDSKLLTEIEI 631
                .|.:..|.:.|::..| ...|.:......:||.|.          :..|:.|..|:..:.|
Human   141 GSRTPKDQKLREAMAALRKS-AQDVQKFMDAVNKKSSSQDLHKGTLSQMSGELSKDGDLIVSMRI 204

  Fly   632 I----TSTFN-------------SRCRIQDDR-----LTGS-------SGKEKLLA--------- 658
            :    |.|::             .:.:::.|.     |:|:       ...:||..         
Human   205 LGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLYVGSRVVAKYK 269

  Fly   659 DANK--LQATLAAPSP-----AQQLTLNGGGPASTLSK----PLKRGLKK----------RKLSE 702
            |.|:  |.|.:.|.:|     .:.|.....|.||.:::    |:.|.|||          |...|
Human   270 DGNQVWLYAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIE 334

  Fly   703 ---------PLV---DFAMLSASASGT------PNGSGS---------------SNGNTKRRHKK 734
                     |:|   ...::.....||      ....||               ..|:|:.....
Human   335 EYVTAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMF 399

  Fly   735 SQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANG-----------------KLNAEAWAAA 782
            |....|:|..:     ||:..|.|   ||......:.|                 .:......|.
Human   400 SMKTSSASALE-----KKQGQLRT---RPNMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAP 456

  Fly   783 AAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVS----GAGSSASNSPLRIVVDNNSIS 843
            .|.....|...|....::.|::|.|...::.:.::.||..    |:|.|:..||..    :.::|
Human   457 PAPPFPPAPPLSPQAGDSESLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSPAL----SENVS 517

  Fly   844 GGKLLDISPSSLCSLKQQRR---GGAAKQKVSAAKDLVQLQSPAGSYPPPGVF---------EPS 896
            |||     |    .:.|..|   |..|.....:|     |.:|    |.|.||         |||
Human   518 GGK-----P----GINQTYRSPLGSTASAPAPSA-----LPAP----PAPPVFHGMLERAPAEPS 564

  Fly   897 VELEIQIPLSKL-------------------NESVITKAEVESPLLSALDIKEDT-KKEVGQRVV 941
                .:.|:.||                   ||....|..:..|||  .|.:..| ::.|.:::.
Human   565 ----YRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPLLVPLL--YDFRRMTARRRVNRKMG 623

  Fly   942 ETLLHKTGGNLLLKRKRKKINRTGFPT-----------------VRRKKRKVSVEQQTTAVIDEH 989
            ..:::||...|.| |..::|.|..|.|                 |.||             ...:
Human   624 FHVIYKTPCGLCL-RTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRK-------------FQPY 674

  Fly   990 EP-------EFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARET---FVARTNQK 1044
            :|       .:..:|.||..:      |.::....|......||:|..|....|   |:...:.|
Human   675 KPFYYILDITYGKEDVPLSCV------NEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCK 733

  Fly  1045 --APRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVL 1107
              ....|..|..:|....|..  .|.|                     :|.|  ..|.|.|:  |
Human   734 DGCRDKSKCACHQLTIQATAC--TPGG---------------------QINP--NSGYQYKR--L 771

  Fly  1108 EEPPPTPPPQ-QKKNKMEPN------------IRLP----------------------------- 1130
            ||..||...: .|:.|.:||            :||.                             
Human   772 EECLPTGVYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGK 836

  Fly  1131 ----------------------DGIDPNTNF-------------SCKIRLKRRKNLEAGTQP--- 1157
                                  |.|:...||             |..:.||.:::..:||:.   
Human   837 ILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE 901

  Fly  1158 ---------------------------------KKEKPVQPVTVEE------------IPPEIPV 1177
                                             :||..:...|.::            :||.|||
Human   902 SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVPPSIPV 966

  Fly  1178 ------SQEEIDAEAEAKRLDSIPTEHDPLPASESH-----NPGPQDYASCSESSEDKASTTSLR 1231
                  |.||......|..|............|:||     |.|.:..|..|....:||||:.|.
Human   967 GGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRMEAEKASTSGLG 1031

  Fly  1232 -------KLSKVKKTYLVAGLFSNHYKQSLMPPPAK---VNKKPGLEEQVGPASLLPPPPYCEKY 1286
                   |.:|.:.|       .:..|.|::...::   .|..|     |.|..|..||.....:
Human  1032 IKDEGDIKQAKKEDT-------DDRNKMSVVTESSRNYGYNPSP-----VKPEGLRRPPSKTSMH 1084

  Fly  1287 LRRTEMDF--ELPYDIWWAYTN---------SKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFD 1340
            ..|..|..  ..|.|:....::         |:.||.....:       |.|.::.::       
Human  1085 QSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSA-------TAVDSDDIQ------- 1135

  Fly  1341 HPTCNCKNQG----EKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQ-RHAVAPGVERFMTADK 1400
              |.:..::|    :|..:...:.|.|          |.:..|...:: .|.:|.......:.||
Human  1136 --TISSGSEGDDFEDKKNMTGPMKRQV----------AVKSTRGFALKSTHGIAIKSTNMASVDK 1188

  Fly  1401 GWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRF 1465
            |    ...|:.|.|            ::|.....|.|               :||.:..|:..|:
Human  1189 G----ESAPVRKNT------------RQFYDGEESCY---------------IIDAKLEGNLGRY 1222

  Fly  1466 VNHSCEPNCEMQK-----------WSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQP-- 1517
            :||||.||..:|.           |       :..||.:.|..|.|||:|||:.: ...||:.  
Human  1223 LNHSCSPNLFVQNVFVDTHDLRFPW-------VAFFASKRIRAGTELTWDYNYEV-GSVEGKELL 1279

  Fly  1518 CRCNTPQCRG 1527
            |.|...:|||
Human  1280 CCCGAIECRG 1289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_524160.2 PHA03247 <1018..1281 CDD:223021 75/413 (18%)
AWS 1340..1388 CDD:197795 8/52 (15%)
SET_ASH1L 1391..1531 CDD:380951 38/150 (25%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
SETDB1NP_001353346.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 108..147 2/38 (5%)
DUF5604 193..250 CDD:408109 8/56 (14%)
Tudor_SETDB1_rpt1 260..341 CDD:410453 17/80 (21%)
Tudor_SETDB1_rpt2 348..401 CDD:410548 6/52 (12%)
MBD 598..673 CDD:128673 19/90 (21%)
SET_SETDB1 675..>876 CDD:380915 39/233 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 869..1161 56/329 (17%)
SET <1203..1292 CDD:394802 31/110 (28%)
Blue background indicates that the domain is not in the aligned region.

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