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Protein Alignment ash1 and KMT2B

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_055542.1	Gene:	KMT2B / 9757	HGNCID:	15840	Length:	2715	Species:	Homo sapiens

Alignment Length:	1110	Identity:	224/1110 - (20%)
Similarity:	337/1110 - (30%)	Gaps:	397/1110 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 RCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGG------------------GPAS 685
            ||||.:.|..|...:...|..|.:.|..:.:|:|:.:..  ||                  .|..
Human  1777 RCRILEYRPWGPREEPAHLEAAEENQTIVHSPAPSSEPP--GGEDPPLDTDVLVPGAPERHSPIQ 1839

  Fly   686 TLSKPLK-----------RGLKKRKLSEPLVDFAMLSASASGTPNGS---------GSSNGNT-- 728
            .|..||:           |.....::..|       :.|.|..|.|.         ||.:..|
Human  1840 NLDPPLRPDSGSAPPPAPRSFSGARIKVP-------NYSPSRRPLGGVSFGPLPSPGSPSSLTHH 1897

  Fly   729 ------------KRRHKKSQSNDSSSPDDH--KLPLKKRHYL-----------LTP--GERPP-- 764
                        .||.::........|...  ..|||....|           |||  ||..|
Human  1898 IPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPG 1962

  Fly   765 --------------------------AEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSV 803
                                      |::.||...|..|.:.....||.:..|:....   ..|.
Human  1963 PAPSPPPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGP---GDSS 2024

  Fly   804 KSALTPKKRHLLEQPTSVSGAGSSASNSP--LRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGA 866
            :...:|..|::....|.||..|.:.|.:|  .||    ..:.|   :|....|.....||.||
Human  2025 EEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRI----EQLDG---VDDGTDSEAEAVQQPRG-- 2080

  Fly   867 AKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKED 931
                        |...|:|    |||                         |.:.:|.|...:..
Human  2081 ------------QGTPPSG----PGV-------------------------VRAGVLGAAGDRAR 2104

  Fly   932 TKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPD 996
            ..:::...:|:.:|...||                                            |.
Human  2105 PPEDLPSEIVDFVLKNLGG--------------------------------------------PG 2125

  Fly   997 DEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAG------EARETFVARTNQKAPRLSVVALER 1055
            |.......|:         ..|.|||.....|..|      :...||.....  ||.:.|::|..
Human  2126 DGGAGPREES---------LPPAPPLANGSQPSQGLTASPADPTRTFAWLPG--APGVRVLSLGP 2179

  Fly  1056 LQRPQTPARGR----PRGRKPKNREQAEAAPQPPPKSEPEIRP-----AKKRGRQPKQPVL---- 1107
            ...|..||..:    .:..:...:...|..|.|||..:|.:.|     |......|..|:|
Human  2180 APEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLP 2244

  Fly  1108 ------EEPPPTPPP-------------------------QQKKNKMEPNIRLP----DG-IDPN 1136
                  ..|||.|||                         ..:.....|..:.|    || ...:
Human  2245 VVGVVRPAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEASED 2309

  Fly  1137 T---------NFSCKIRLKR----------RKNLEAGTQ---PKKEK-PVQPVTVEEIPPEIPVS 1178
            |         .|| ::|:|.          |....||.:   |.:|: |:.|:. |:.||::|..
Human  2310 TPQVPGLGSGGFS-RVRMKTPTVRGVLDLDRPGEPAGEESPGPLQERSPLLPLP-EDGPPQVPDG 2372

  Fly  1179 QEEIDAEAEAKRL--DSIPTEHDPLPASESHNPGP-------------QDYASCSESSEDKASTT 1228
            ..::..|::....  ::..:|.:|....:..|..|             :|..|....|.:.|..|
Human  2373 PPDLLLESQWHHYSGEASSSEEEPPSPDDKENQAPKRTGPHLRFEISSEDGFSVEAESLEGAWRT 2437

  Fly  1229 SLRKLSKVKKTYLV----------AGLFSNHYKQSLMPPPAKVNKKPGLE---------EQVGPA 1274
            .:.|:.:.:....:          |.|...|:...:.    ...:.||.:         .|.|..
Human  2438 LIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIF----LAEQLPGAQRCQHYKFRYHQQGEG 2498

  Fly  1275 SLLPP-PPY----CEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRTNVYAESVRP 1334
            ...|| .|:    .|.|||:...|.                       :|:...:..|..|..
Human  2499 QEEPPLNPHGAARAEVYLRKCTFDM-----------------------FNFLASQHRVLPEGA-- 2538

  Fly  1335 NLAGFDHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRN-QKIQRHAVAPGVERFMTA 1398
                    ||   ::.|.........|....|     .|...:.|: :|..:.||  ||.|  :|
Human  2539 --------TC---DEEEDEVQLRSTRRATSLE-----LPMAMRFRHLKKTSKEAV--GVYR--SA 2583

  Fly  1399 DKGWGVRTKLPIAKGTYILEYVGEVV-------TEKEFKQRMASIYLNDTHHYCLHLDGGLVIDG 1456
            ..|.|:..|..|..|..::||.|.|:       .||.:..:....|:       ..:|...|:|.
Human  2584 IHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYM-------FRMDDFDVVDA 2641

  Fly  1457 QRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCN 1521
            ...|:..||:||||||||..:...|.|...:|:||.|.|..||||||||.|.:.:.|...||.|.
Human  2642 TMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCG 2706

  Fly  1522 TPQCR 1526
            ..:||
Human  2707 AKRCR 2711

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.