DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and SETD1A

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_055527.1 Gene:SETD1A / 9739 HGNCID:29010 Length:1707 Species:Homo sapiens


Alignment Length:1828 Identity:360/1828 - (19%)
Similarity:575/1828 - (31%) Gaps:619/1828 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 QNETAAAKVLETQRAQESGSENEETDSITDQSSQSKSIKSA----------------TQFSVQRS 53
            |......|.| :::.|.||:..|..:|....||.:.:..:.                |.||..|.
Human   191 QTVPTGGKAL-SEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQ 254

  Fly    54 DTDGLRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGIS 118
            ||                      |.|....|..:..|.......:    ....:....|||..|
Human   255 DT----------------------PSSFGQFTPQSSQGTPYTSRGS----TPYSQDSAYSSSTTS 293

  Fly   119 KSDKVSKSKKSQISAFS----SDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSD 179
            .|.|..:|:.|...|||    |.|      ......:..:..:....|:.|||..:|....|||.
Human   294 TSFKPRRSENSYQDAFSRRHFSAS------SASTTASTAIAATTAATASSSASSSSLSSSSSSSS 352

  Fly   180 NELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQ----DFMEKTQMLGQTVNAK 240
            :...:..::      ||........|:.:..:..:.|..::|..:    .|.|.|          
Human   353 SSSSSQFRS------SDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENT---------- 401

  Fly   241 LAEEKVAKAKEETLVQTAVPRKRRGRP---KKVVPTVPAPGNSGPAINESADSGVISTT----ST 298
             ||............:.:.|..:..||   :...|..|.||..|.....|.:...:.|:    |.
Human   402 -AERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASP 465

  Fly   299 TQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACS 363
            .:|.:|:|:..||      |:|.|..|.       ||.|:   |.:|       :.|.:|.:..:
Human   466 ARSGSPAPETTNE------SVPFAQHSS-------LDSRI---EMLL-------KEQRSKFSFLA 507

  Fly   364 SSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICS---------KVLAAKSGYVSDY 419
            |..:||          :.|....|.:...|:...:|:....|:         .|....||   :.
Human   508 SDTEEE----------EENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSG---EP 559

  Fly   420 GSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASM 484
            |:.|....::..|                       :|..|                        
Human   560 GATRESPKANGQN-----------------------QASPC------------------------ 577

  Fly   485 LLKSSADD-TVEDQD-------------------------ILQLAGLSLGQSSEESNEYISKPSL 523
               ||.|| .:.|.|                         ...||.|.||....:. .|:..|. 
Human   578 ---SSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQP-AYLLPPR- 637

  Fly   524 KSLPTTSASKKY-------GEINRYVTTGQYFGRGGSLSATNPDNF------ISKMMNQRK---- 571
               |......:|       ..|..:|.:.:...|.|:.....|.:|      ::::...|:    
Human   638 ---PDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGL 699

  Fly   572 -----------------ETPAPSKSSCKIK--------------SRRS-------SAASMCSSYV 598
                             ..|.|.:::..:.              ||.:       :|..:.||.|
Human   700 IAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSV 764

  Fly   599 SGVSRMRRRHRRKSFSHNKSL-------NIDSKLLTEIEIITSTFNSRCRIQ-------DDRLTG 649
            ||.............:..|:|       .:.:.|:.|::.|.....:|..::       |.....
Human   765 SGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWES 829

  Fly   650 SSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEP----LVDFAML 710
            ...|.|...:|.|.||.                         :...:|.||.||    |||:   
Human   830 KEEKAKPFQNAAKQQAK-------------------------EEDKEKTKLKEPGLLSLVDW--- 866

  Fly   711 SASASGTPN------GSG-------------------SSNGNTKRRHKKS--QSNDSSSPDDHKL 748
             |.:.||..      |||                   .|..:.::|.:.|  ...|...|:..|.
Human   867 -AKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKE 930

  Fly   749 PLKKRHYLLTPGERPP---AEVAFANGK------LNAEAWAAAAAAAKSTASTKSQAQFNARSVK 804
            ..:...    ||.:||   .|.....||      |::|...|:..::........:........:
Human   931 AGEPGR----PGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDRE 991

  Fly   805 SALTPKKRHLLEQPTSVSGAGSSASNSPLRIVV------DNNSISGGKLLDISPSSLCSLKQQRR 863
            .|:...|:.     |.||......|:|..:..:      :|:|.|..:....|.||..|......
Human   992 EAVDTTKKE-----TEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSS 1051

  Fly   864 GGAAKQKVSAAKDLVQLQSPA---GSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSA 925
            ..::....|:::|..:.:.||   .:.|||        .|:.:|         |.|.||.|:   
Human  1052 SSSSSSSESSSEDEEEEERPAALPSASPPP--------REVPVP---------TPAPVEVPV--- 1096

  Fly   926 LDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHE 990
                  .::..|..|..           |..:.....|...||         .|...:|.:...|
Human  1097 ------PERVAGSPVTP-----------LPEQEASPARPAGPT---------EESPPSAPLRPPE 1135

  Fly   991 PEFD-------PDDEPLQSL---------RETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVA 1039
            |...       ||:.|...:         |:|.|.:.:.|..||.||  ....|||     .|..
Human  1136 PPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPP--PATPPQA-----KFPG 1193

  Fly  1040 RTNQKAPRLSVVALERLQR-------------PQTPAR-GRPR-GRKPKNREQAEAAPQPPPK-- 1087
            ..::||||    .:||..|             |:..:| ||.| |.:.:..|:.||.|.....  
Human  1194 PASRKAPR----GVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLA 1254

  Fly  1088 --SEPEIRPAKKRGRQPKQPVLEEPPPT--------PPPQQKKNKMEPNIRLPDGIDPNTNFSCK 1142
              ::..:.|| :|| .|..|.:|:...|        |.|......:|.|..|  .:.|       
Human  1255 VLADLALTPA-RRG-LPALPAVEDSEATETSDEAERPRPLLSHILLEHNYAL--AVKP------- 1308

  Fly  1143 IRLKRRKNLEAGTQPKKE-KPVQPV---------TVEEI--PPEIPVSQEEIDAEAEAKRLDSIP 1195
                        |.|... :|.:||         ..:|:  .||:.|::.|   |.:.::|....
Human  1309 ------------TPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAE---EPKPQQLQQQR 1358

  Fly  1196 TEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAK 1260
            .|.:    .|....|.::....|:||.......:||:.|           ..:|.::...|||  
Human  1359 EEGE----EEGEEEGEEEEEESSDSSSSSDGEGALRRRS-----------LRSHARRRRPPPP-- 1406

  Fly  1261 VNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMD-FELPYDIWWAYTNSKLPTRNVV--------- 1315
                             ||||....|..|:|.: ..:.||||    ||.|.:.::.         
Human  1407 -----------------PPPPPPRAYEPRSEFEQMTILYDIW----NSGLDSEDMSYLRLTYERL 1450

  Fly  1316 ------------PSWNYRKIRTNVYA--ESVRPNLAGFDHPTCNCKNQG-------EK-SCLDNC 1358
                        ..|.:..| ||:..  ...||.....:|.|.:.:::|       || ..||.|
Human  1451 LQQTSGADWLNDTHWVHHTI-TNLTTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVC 1514

  Fly  1359 ---LNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTAD--------------------- 1399
               ..::...:...:|....|:...|:  |...|.|....|.:|                     
Human  1515 PVSARQLEGVDTQGTNRVLSERRSEQR--RLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRI 1577

  Fly  1400 KGWGVRTKLPIAKGTYILEYVGEVV-------TEKEFKQR-MASIYLNDTHHYCLHLDGGLVIDG 1456
            ..||:....|||....::||||:.:       .||.:.|. :.|.||       ..:|...:||.
Human  1578 HEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYL-------FRVDHDTIIDA 1635

  Fly  1457 QRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQ--PCR 1519
            .:.|:..||:||.|.|||..:..::....::|:::|:.|...||:||||.|    |.|..  ||.
Human  1636 TKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKF----PLEDNKIPCL 1696

  Fly  1520 CNTPQCRG 1527
            |.|..|||
Human  1697 CGTESCRG 1704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 12/58 (21%)
SET 1392..1512 CDD:214614 39/148 (26%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
SETD1ANP_055527.1 RRM_Set1A 92..186 CDD:240992
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..308 27/140 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 331..363 8/37 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..486 26/121 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..655 31/216 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..854 6/44 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..1251 86/425 (20%)
DNA_pol3_delta2 <1070..>1130 CDD:331068 19/105 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1264..1293 9/30 (30%)
HCFC1-binding motif (HBM) 1299..1303 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1307..1417 31/165 (19%)
Interaction with CFP1 1415..1450 10/38 (26%)
N-SET 1425..1562 CDD:314603 29/143 (20%)
Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269|PubMed:17998332 1450..1537 16/87 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1472..1499 5/26 (19%)
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 1492..1497 0/4 (0%)
SET 1568..1691 CDD:214614 39/133 (29%)
PostSET 1691..1707 CDD:214703 7/14 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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