DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ash1 and SETD1A

DIOPT Version :10

Sequence 1:NP_524160.2 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_055527.1 Gene:SETD1A / 9739 HGNCID:29010 Length:1707 Species:Homo sapiens


Alignment Length:1828 Identity:360/1828 - (19%)
Similarity:575/1828 - (31%) Gaps:619/1828 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 QNETAAAKVLETQRAQESGSENEETDSITDQSSQSKSIKSA----------------TQFSVQRS 53
            |......|.| :::.|.||:..|..:|....||.:.:..:.                |.||..|.
Human   191 QTVPTGGKAL-SEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQ 254

  Fly    54 DTDGLRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGIS 118
            ||                      |.|....|..:..|.......:    ....:....|||..|
Human   255 DT----------------------PSSFGQFTPQSSQGTPYTSRGS----TPYSQDSAYSSSTTS 293

  Fly   119 KSDKVSKSKKSQISAFS----SDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSD 179
            .|.|..:|:.|...|||    |.|      ......:..:..:....|:.|||..:|....|||.
Human   294 TSFKPRRSENSYQDAFSRRHFSAS------SASTTASTAIAATTAATASSSASSSSLSSSSSSSS 352

  Fly   180 NELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQ----DFMEKTQMLGQTVNAK 240
            :...:..::      ||........|:.:..:..:.|..::|..:    .|.|.|          
Human   353 SSSSSQFRS------SDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENT---------- 401

  Fly   241 LAEEKVAKAKEETLVQTAVPRKRRGRP---KKVVPTVPAPGNSGPAINESADSGVISTT----ST 298
             ||............:.:.|..:..||   :...|..|.||..|.....|.:...:.|:    |.
Human   402 -AERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASP 465

  Fly   299 TQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACS 363
            .:|.:|:|:..||      |:|.|..|.       ||.|:   |.:|       :.|.:|.:..:
Human   466 ARSGSPAPETTNE------SVPFAQHSS-------LDSRI---EMLL-------KEQRSKFSFLA 507

  Fly   364 SSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICS---------KVLAAKSGYVSDY 419
            |..:||          :.|....|.:...|:...:|:....|:         .|....||   :.
Human   508 SDTEEE----------EENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSG---EP 559

  Fly   420 GSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASM 484
            |:.|....::..|                       :|..|                        
Human   560 GATRESPKANGQN-----------------------QASPC------------------------ 577

  Fly   485 LLKSSADD-TVEDQD-------------------------ILQLAGLSLGQSSEESNEYISKPSL 523
               ||.|| .:.|.|                         ...||.|.||....:. .|:..|. 
Human   578 ---SSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQP-AYLLPPR- 637

  Fly   524 KSLPTTSASKKY-------GEINRYVTTGQYFGRGGSLSATNPDNF------ISKMMNQRK---- 571
               |......:|       ..|..:|.:.:...|.|:.....|.:|      ::::...|:    
Human   638 ---PDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGL 699

  Fly   572 -----------------ETPAPSKSSCKIK--------------SRRS-------SAASMCSSYV 598
                             ..|.|.:::..:.              ||.:       :|..:.||.|
Human   700 IAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSV 764

  Fly   599 SGVSRMRRRHRRKSFSHNKSL-------NIDSKLLTEIEIITSTFNSRCRIQ-------DDRLTG 649
            ||.............:..|:|       .:.:.|:.|::.|.....:|..::       |.....
Human   765 SGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWES 829

  Fly   650 SSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEP----LVDFAML 710
            ...|.|...:|.|.||.                         :...:|.||.||    |||:   
Human   830 KEEKAKPFQNAAKQQAK-------------------------EEDKEKTKLKEPGLLSLVDW--- 866

  Fly   711 SASASGTPN------GSG-------------------SSNGNTKRRHKKS--QSNDSSSPDDHKL 748
             |.:.||..      |||                   .|..:.::|.:.|  ...|...|:..|.
Human   867 -AKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKE 930

  Fly   749 PLKKRHYLLTPGERPP---AEVAFANGK------LNAEAWAAAAAAAKSTASTKSQAQFNARSVK 804
            ..:...    ||.:||   .|.....||      |::|...|:..::........:........:
Human   931 AGEPGR----PGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDRE 991

  Fly   805 SALTPKKRHLLEQPTSVSGAGSSASNSPLRIVV------DNNSISGGKLLDISPSSLCSLKQQRR 863
            .|:...|:.     |.||......|:|..:..:      :|:|.|..:....|.||..|......
Human   992 EAVDTTKKE-----TEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSS 1051

  Fly   864 GGAAKQKVSAAKDLVQLQSPA---GSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSA 925
            ..::....|:::|..:.:.||   .:.|||        .|:.:|         |.|.||.|:   
Human  1052 SSSSSSSESSSEDEEEEERPAALPSASPPP--------REVPVP---------TPAPVEVPV--- 1096

  Fly   926 LDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHE 990
                  .::..|..|..           |..:.....|...||         .|...:|.:...|
Human  1097 ------PERVAGSPVTP-----------LPEQEASPARPAGPT---------EESPPSAPLRPPE 1135

  Fly   991 PEFD-------PDDEPLQSL---------RETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVA 1039
            |...       ||:.|...:         |:|.|.:.:.|..||.||  ....|||     .|..
Human  1136 PPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPP--PATPPQA-----KFPG 1193

  Fly  1040 RTNQKAPRLSVVALERLQR-------------PQTPAR-GRPR-GRKPKNREQAEAAPQPPPK-- 1087
            ..::||||    .:||..|             |:..:| ||.| |.:.:..|:.||.|.....  
Human  1194 PASRKAPR----GVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLA 1254

  Fly  1088 --SEPEIRPAKKRGRQPKQPVLEEPPPT--------PPPQQKKNKMEPNIRLPDGIDPNTNFSCK 1142
              ::..:.|| :|| .|..|.:|:...|        |.|......:|.|..|  .:.|       
Human  1255 VLADLALTPA-RRG-LPALPAVEDSEATETSDEAERPRPLLSHILLEHNYAL--AVKP------- 1308

  Fly  1143 IRLKRRKNLEAGTQPKKE-KPVQPV---------TVEEI--PPEIPVSQEEIDAEAEAKRLDSIP 1195
                        |.|... :|.:||         ..:|:  .||:.|::.|   |.:.::|....
Human  1309 ------------TPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAE---EPKPQQLQQQR 1358

  Fly  1196 TEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAK 1260
            .|.:    .|....|.::....|:||.......:||:.|           ..:|.::...|||  
Human  1359 EEGE----EEGEEEGEEEEEESSDSSSSSDGEGALRRRS-----------LRSHARRRRPPPP-- 1406

  Fly  1261 VNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMD-FELPYDIWWAYTNSKLPTRNVV--------- 1315
                             ||||....|..|:|.: ..:.||||    ||.|.:.::.         
Human  1407 -----------------PPPPPPRAYEPRSEFEQMTILYDIW----NSGLDSEDMSYLRLTYERL 1450

  Fly  1316 ------------PSWNYRKIRTNVYA--ESVRPNLAGFDHPTCNCKNQG-------EK-SCLDNC 1358
                        ..|.:..| ||:..  ...||.....:|.|.:.:::|       || ..||.|
Human  1451 LQQTSGADWLNDTHWVHHTI-TNLTTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVC 1514

  Fly  1359 ---LNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTAD--------------------- 1399
               ..::...:...:|....|:...|:  |...|.|....|.:|                     
Human  1515 PVSARQLEGVDTQGTNRVLSERRSEQR--RLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRI 1577

  Fly  1400 KGWGVRTKLPIAKGTYILEYVGEVV-------TEKEFKQR-MASIYLNDTHHYCLHLDGGLVIDG 1456
            ..||:....|||....::||||:.:       .||.:.|. :.|.||       ..:|...:||.
Human  1578 HEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYL-------FRVDHDTIIDA 1635

  Fly  1457 QRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQ--PCR 1519
            .:.|:..||:||.|.|||..:..::....::|:::|:.|...||:||||.|    |.|..  ||.
Human  1636 TKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKF----PLEDNKIPCL 1696

  Fly  1520 CNTPQCRG 1527
            |.|..|||
Human  1697 CGTESCRG 1704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_524160.2 PHA03247 <1018..1281 CDD:223021 65/301 (22%)
AWS 1340..1388 CDD:197795 12/58 (21%)
SET_ASH1L 1391..1531 CDD:380951 49/168 (29%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
SETD1ANP_055527.1 Interaction with WDR82. /evidence=ECO:0000269|PubMed:37030068 60..89
RRM_Set1A 92..186 CDD:409964
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..308 27/140 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 331..363 8/37 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..486 26/121 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..655 31/216 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..854 6/44 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..1251 86/425 (20%)
PRK12323 <1070..>1130 CDD:481241 19/105 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1264..1293 9/30 (30%)
HCFC1-binding motif (HBM) 1299..1303 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1307..1417 31/165 (19%)
Interaction with CFP1 1415..1450 10/38 (26%)
N-SET 1425..1562 CDD:463344 29/143 (20%)
Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269|PubMed:17998332 1450..1537 16/87 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1472..1499 5/26 (19%)
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 1492..1497 0/4 (0%)
RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827 1537..1542 1/6 (17%)
SET_SETD1 1556..1703 CDD:380946 44/157 (28%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.