Protein Alignment ash1 and SET1

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_011987.1
• Gene: SET1 / 856519
• SGDID: S000001161
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 1340
• Identity: 255/1340 - (19%)
• Similarity: 402/1340 - (30%)
• Gaps: 506/1340 - (37%)

  Fly   411 AKSGYV--------SDYGSVRHQRSSHNHNSG----YKSD-------ASCKSRYSTKSCMSRRSR 456
            ::||:.        ..|.|..:||..:|||.|    |..|       ||.:..|:|
Yeast    25 SRSGHYQYSNGHSHQQYSSQYNQRRRYNHNDGTRRRYNDDRPHSSNNASTRQYYAT--------- 80

  Fly   457 AKSCGYRSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKP 521
                       .:.:||..:.:|                 .||....|:|..:.|..:.......
Yeast    81 -----------NNSQSGPYVNKK-----------------SDISSRRGMSQSRYSNSNVHNTLAS 117

  Fly   522 SLKSLPTTSA---SKKYGEINRYVT-------------TGQYFGRGGSLSATNPDNFISKMMNQR 570
            |..||||.||   .::...:.||.|             .|::|.:...||....|...|:
Yeast   118 SSGSLPTESALLLQQRPPSVLRYNTDNLKSKFHYFDPIKGEFFNKDKMLSWKATDKEFSE----- 177

  Fly   571 KETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITST 635
                              :...:......|..:.:.:||......:...| ::.::|..::.|
Yeast   178 ------------------TGYYVVKELQDGQFKFKIKHRHPEIKASDPRN-ENGIMTSGKVAT-- 221

  Fly   636 FNSRC--------RIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLK 692
             :.:|        ||..||.                                      :|..|
Yeast   222 -HRKCRNSLILLPRISYDRY--------------------------------------SLGPP-- 245

  Fly   693 RGLKKRKLSEPLVDFAMLSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRH-YL 756
                      |..:..:..|..|.|.|....|..|..:::.:....::.:..:..|||   | ||
Yeast   246 ----------PSCEIVVYPAQDSTTTNIQDISIKNYFKKYGEISHFEAFNDPNSALPL---HVYL 297

  Fly   757 LTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTAS------TKSQAQFNARSVKSALTPKKRHLL 815
            :        :.|.::||:|..|.||.:|..|..:|      .|.:...|..|:.
Yeast   298 I--------KYASSDGKINDAAKAAFSAVRKHESSGCFIMGFKFEVILNKHSIL----------- 343

  Fly   816 EQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAKDLVQL 880
                                   ||.||  |.::|:...|..|::..:  .||:|.:..:...:|
Yeast   344 -----------------------NNIIS--KFVEINVKKLQKLQENLK--KAKEKEAENEKAKEL 381

  Fly   881 QSPAGSYPPPGVFEPSVEL-------EIQIPLSKL----NESV--ITKAEVESPLLSALDIKEDT 932
            |....:.|.    ||.|:.       |.:||...|    |..|  ::|..|........|.|...
Yeast   382 QGKDITLPK----EPKVDTLSHSSGSEKRIPYDLLGVVNNRPVLHVSKIFVAKHRFCVEDFKYKL 442

  Fly   933 KKEVGQRVVETLLHKTG-------------------GNLLLKRKRKKI--------------NRT 964
            :   |.|..:.:.|.||                   |||.:..:.::|              |||
Yeast   443 R---GYRCAKFIDHPTGIYIIFNDIAHAQTCSNAESGNLTIMSRSRRIPILIKFHLILPRFQNRT 504

  Fly   965 GFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQ 1029
            .|.                                    :.:.|||:.||      |:..|...:
Yeast   505 RFN------------------------------------KSSSSSNSTNV------PIKYESKEE 527

  Fly  1030 AGEARETFVARTNQKAPRLSVV----------ALERLQRPQTPARGRPRGRKPKNREQAEAAPQP 1084
            ..||....:.:..:|...:.:.          ||:....|:..|:     |:.|.:|:.:.....
Yeast   528 FIEATAKQILKDLEKTLHVDIKKRLIGPTVFDALDHANFPELLAK-----RELKEKEKRQQIASK 587

  Fly  1085 PPKSEPEIRPAKKR--------GRQPKQPVLEEPPPTPPPQQKKNKMEPNI-----------RLP 1130
            ..:.|.:.:...||        |...|             ..|:|....|.           :|.
Yeast   588 IAEDELKRKEEAKRDFDLFGLYGGYAK-------------SNKRNLKRHNSLALDHTSLKRKKLS 639

  Fly  1131 DGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPE--------IPVSQEEIDAEAE 1187
            :||.|..:.           |...|..|:..|:....:..:..|        ...|.||.:.||.
Yeast   640 NGIKPMAHL-----------LNEETDSKETTPLNDEGITRVSKEHDEEDENMTSSSSEEEEEEAP 693

  Fly  1188 AKRLDSIPTEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQ 1252
            .|:..|   |.:|......|..|.:........|.|....:|:.|
Yeast   694 DKKFKS---ESEPTTPESDHLHGIKPLVPDQNGSSDVLDASSMYK-------------------- 735

  Fly  1253 SLMPPPAKVNKKPGLEEQVGPASLLPPPPYCEKYLR-----------RTEMDFELPYDIWWAYTN 1306
               |...::           |..:.||..|..||.:           :.|.|..:...:...||.
Yeast   736 ---PTATEI-----------PEPVYPPEEYDLKYSQTLSSMDLQNAIKDEEDMLILKQLLSTYTP 786

  Fly  1307 SKLPTRNVVPSWNYRKIRTNVYAE------SVRPNLAGFD---HPTCNCKNQGEKSCLD----NC 1358
            :..|..:....:...:.|..|..|      .:..|...||   .|..:.|.:|.:...|    |.
Yeast   787 TVTPETSAALEYKIWQSRRKVLEEEKASDWQIELNGTLFDSELQPGSSFKAEGFRKIADKLKINY 851

  Fly  1359 L--NRMVY------------TECSPSNCPAGEKCR------------------------NQKIQR 1385
            |  .|.|:            .|.:|..|...|...                        .|.|:.
Yeast   852 LPHRRRVHQPLNTVNIHNERNEYTPELCQREESSNKEPSDSVPQEVSSSRDNRASNRRFQQDIEA 916

  Fly  1386 HAVAPGVERFM-----------------TADKGWGVRTKLPIAKGTYILEYVGEVV-------TE 1426
            ...|.|.|..:                 :|...||:.....||....|:|||||.:       .|
Yeast   917 QKAAIGTESELLSLNQLNKRKKPVMFARSAIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMRE 981

  Fly  1427 KEF-KQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLF 1490
            |.: |..:.|.||       ..:|...|||..:.|...||:||.|:|||..:...|.|..|:|::
Yeast   982 KRYLKNGIGSSYL-------FRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIY 1039

  Fly  1491 AKRAIEEGEELTYDYNFSLFNPSEGQ-PCRCNTPQCRGVI 1529
            |.|.|...|||||||.|......|.: ||.|..|.|:|.:
Yeast  1040 ALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNCKGFL 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	48/299 (16%)
		AWS	1340..1388	CDD:197795	15/92 (16%)
		SET_ASH1L	1391..1531	CDD:380951	54/165 (33%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
SET1	NP_011987.1	AF-4	<11..>136	CDD:461550	31/147 (21%)
		RRM_scSet1p_like	246..360	CDD:409743	33/160 (21%)
		SET_assoc	422..486	CDD:432058	12/66 (18%)
		N-SET	763..932	CDD:463344	28/168 (17%)
		SET_SET1	926..1076	CDD:380998	50/156 (32%)