DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ash1 and SET3

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_012954.3	Gene:	SET3 / 853900	SGDID:	S000001737	Length:	751	Species:	Saccharomyces cerevisiae

Alignment Length:	315	Identity:	78/315 - (24%)
Similarity:	120/315 - (38%)	Gaps:	90/315 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1769 EGKEKALQSLK-----------DSYEQQKIASYVQLVEILGDSESLQSFKPKEVLSSEEEPGKIA 1822
            :||::|.::.|           :|:|::|..:.......|..:.:: |...|:  ::|:...:.|
Yeast    23 KGKKRAEEASKIGSKTDTIEHDESHEREKKGAIEMAAAALATASTV-SLPLKK--ATEQSAAEAA 84

  Fly  1823 VKKSPGAKERDSPIVPLKVTPPPLLPIEAS----PDEDVIRCICGLYKDEGLMIQCSKCMVWQHT 1883
            .  |..||| ::...|.|   .|..|:..|    ||..:|.|||.|..|:|..|||..|..|||.
Yeast    85 T--STAAKE-ETENQPQK---QPQWPVPDSYIVDPDAGIITCICDLNDDDGFTIQCDHCNRWQHA 143

  Fly  1884 EC---TKADIDADNYQCERCEPREVD----REIPLEEFT----------------EEGHRYYLSL 1925
            .|   ....:..|:|.|..|:|||||    |:|..|...                ..|.....|.
Yeast   144 ICYGIKDIGMAPDDYLCNSCDPREVDINLARKIQQERINVKTVEPSSSNNSASNKNNGRDRASST 208

  Fly  1926 MRGDLQVRQGDAVYVLRD-----------------IPIKDESGKV--------LPTKKHTY---- 1961
            ...|:    ||:....:|                 |..|:||..|        :|.||..:
Yeast   209 TISDV----GDSFSTDQDNTNHRDKRRKRNPSNNSIDSKNESASVNSSDGLTSMPKKKEHFLSAK 269

  Fly  1962 ETIGAIDYQECDIFRVEHLWKNELGKRFIFGHH-----FLRPHETFHEPSRRFYP 2011
            :..|||.....|     :::|::|.:.|:..|.     ...||:||...|....|
Yeast   270 DAYGAIYLPLKD-----NVFKSDLIEPFLNKHMDDNWVIQYPHKTFKSVSIEVKP 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795
		SET	1392..1512	CDD:214614
		Bromo_ASH1	1680..1787	CDD:99955	6/28 (21%)
		PHD_ASH1L	1858..1900	CDD:277023	18/44 (41%)
		BAH_polybromo	1929..2073	CDD:240068	26/117 (22%)
SET3	NP_012954.3	PHD_MLL5	119..163	CDD:277025	17/43 (40%)
SET3	NP_012954.3	SET	217..722	CDD:225491	23/108 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030