DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and SET2

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_012367.2	Gene:	SET2 / 853271	SGDID:	S000003704	Length:	733	Species:	Saccharomyces cerevisiae

Alignment Length:	657	Identity:	162/657 - (24%)
Similarity:	254/657 - (38%)	Gaps:	143/657 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1327 VYAESVRPNLAGFDHPTCNCKNQ---GEKSCLD---NCLNRMVYTECSPSNCPA-GEKCRNQKIQ 1384
            :||..........|...|:|..:   |.....|   :|:||:...||....|.: |..|:||:.|
Yeast    51 IYANKRIGTFKNNDFMECDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQ 115

  Fly  1385 RHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASI-YLNDTHHYCLHL 1448
            :...|| :..|.|..||:|||.:..|....:|.||.|||:.|.||:.|:... ..:..|.|.:.|
Yeast   116 KKQYAP-IAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMML 179

  Fly  1449 DGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPS 1513
            ..|..||....||..||.||||.||..:.||.|....||.:||:|.|.:|||:|:|||...:. :
Yeast   180 QNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYG-A 243

  Fly  1514 EGQPCRCNTPQCRGVIGGKSQ--RVKPLPAVEAKPSGEGLSGRNGRQRK-QKAKK---------- 1565
            :.|.|.|..|.|.|.:|||:|  ....||...|...|..:|    .::| .|.||
Yeast   244 QAQKCYCEEPNCIGFLGGKTQTDAASLLPQNIADALGVTVS----MEKKWLKLKKLSGEPIIKNE 304

  Fly  1566 -------HAQRQAGKDISSAVAVAKLQP-LSEKEKKLVRQFNTFLVRNF----EKIRRCKAKRAS 1618
                   ..|....:.|.|.|.|.|:.. |.:::.|::.  :..|.|.|    :.:|....|...
Yeast   305 NENINIEFLQSLEVQPIDSPVDVTKIMSVLLQQDNKIIA--SKLLKRLFTIDDDSLRHQAIKLHG 367

  Fly  1619 DAAATASSPALGTTNGDIPGR---------------------RPSTPSSPSLAAQISALCSPRNI 1662
            ....:.......|....:.|:                     .|.|..:...::||..:......
Yeast   368 YTCFSKMLKLFITEQPQVDGKGNETEEDDIKFIKGILDFLLELPKTTRNGIESSQIDNVVKTLPA 432

  Fly  1663 KTRGLTQAVHDPELEKMAKM----AVVLRDICSAMETLKMSDLLTT-------VSSKKKKPI--- 1713
            |...|.... |..|||.:|.    .:..:||..|..  ||.||...       :..:..:|:
Yeast   433 KFPFLKPNC-DELLEKWSKFETYKRITKKDINVAAS--KMIDLRRVRLPPGWEIIHENGRPLYYN 494

  Fly  1714 ---KTTL------SGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQL----FVEAKQQH 1765
               ||.|      |.|:.|:.:.::|...|     ..|..|||...|....:|    :...||:.
Yeast   495 AEQKTKLHYPPSGSSKVFSSRSNTQVNSPS-----SSGIPKTPGALDSKKHKLSDEEYERKKQKR 554

  Fly  1766 GD------DEGKEKALQSLKDSYEQQKIASYVQLVEILGDS---ESLQSFKPKEVLSSEEE---- 1817
            .:      :..|::.|:|||...:.:.....| |.:|:.::   :.||..:.|:::.::|.
Yeast   555 LEYERIALERAKQEELESLKQKLKLENERKSV-LEDIIAEANKQKELQKEEAKKLVEAKEAKRLK 618

  Fly  1818 ----------------------PGKIAVKKSPGAKERD--------SPIVPLKVTPPPLLPIEAS 1852
                                  |.  .:||:|.:|:.|        ..||.:..|.........:
Yeast   619 RKTVSQSQRLEHNWNKFFASFVPN--LIKKNPQSKQFDHENIKQCAKDIVKILTTKELKKDSSRA 681

  Fly  1853 PDEDVIR 1859
            |.:|:.:
Yeast   682 PPDDLTK 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	16/54 (30%)
		SET	1392..1512	CDD:214614	50/120 (42%)
		Bromo_ASH1	1680..1787	CDD:99955	30/139 (22%)
		PHD_ASH1L	1858..1900	CDD:277023	0/2 (0%)
		BAH_polybromo	1929..2073	CDD:240068
SET2	NP_012367.2	AWS	64..119	CDD:197795	16/54 (30%)
		SET_SETD2	119..260	CDD:380949	58/142 (41%)
		SET	215..695	CDD:225491	105/492 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940