Protein Alignment ash1 and RSC1

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_011570.1
• Gene: RSC1 / 852947
• SGDID: S000003288
• Length: 928
• Species: Saccharomyces cerevisiae
• Alignment Length: 628
• Identity: 124/628 - (19%)
• Similarity: 216/628 - (34%)
• Gaps: 204/628 - (32%)

  Fly  1743 HYKTPQEFDDHMQQLFVEAKQQHGDDEG------------KEKALQSLKDSYEQQKIASYVQLVE 1795
            ||.:||:|.:...|:...|...:..|..            |.|.:.:::..|.:....|..::.|
Yeast    66 HYTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAILLESFIKGKIVHNIRKHYPEVTYPSLGRIPE 130

  Fly  1796 ILGDSESLQ----SFKPKEVLSSEEEPG-----KIAVKKSPGA-------------KERDSPIVP 1838
            |.  :||:|    |..|.....::|:.|     |:|..|...:             ::::||..|
Yeast   131 IF--AESMQPSDLSSNPINTQENDEKAGLNPEMKMAFAKLDSSITERKPTNQDYRMQQKNSPAFP 193

  Fly  1839 ---LKVTPPPL---LPI-------EASPDEDVIR----CICGLYKDEGLMIQCSKCMVWQHTECT 1886
               ..:||.||   .|:       .|.|...|.|    .|     |...:::....:     :..
Yeast   194 THSASITPQPLASPTPVVNYANITSAHPKTHVRRGRPPVI-----DLPYVLRIKNIL-----KMM 248

  Fly  1887 KADIDADNYQCERCEPREVDR-EIP--------------------------LEEFTEE------G 1918
            :.::|.:|.....|..:..|| |.|                          ...|.|:      .
Yeast   249 RREVDQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTN 313

  Fly  1919 HRYYLS------------------LMRGDLQ------VRQGDAVYVLRDIPIKDESGKVLPTKKH 1959
            .:.|.|                  |:|.:|.      :.:|:..|.|.|:.|.||.
Yeast   314 FKLYYSQDQSNIIRAQLLEKNFNRLVRIELSKPDEDYLPEGELRYPLDDVEINDEK--------- 369

  Fly  1960 TYETIGAIDYQECD-----------------IFRVEHLWKNELGKRFIFGHHFLRPHETFHEPSR 2007
                     ||..|                 |||   ||....|.:::....:.||.:|.|...|
Yeast   370 ---------YQIGDWVLLHNPNDINKPIVGQIFR---LWSTTDGNKWLNACWYFRPEQTVHRVDR 422

  Fly  2008 RFYPNEVVRVSLYEVVPIELVIGRCWVLDRTTFCKGRP-MECNDEDHCYICELRVDKTARFFSKA 2071
            .||.|||::...|...||:.:.|:|:|:..|.|.:|.| .:.|...  ::||.|.:::.:.|:|.
Yeast   423 LFYKNEVMKTGQYRDHPIQDIKGKCYVIHFTRFQRGDPSTKVNGPQ--FVCEFRYNESDKVFNKI 485

  Fly  2072 KANHPAC--------------TKSYAFRKFPEKIKISKSYAPHDVDPSLLKTRKQKTELDVGAGP 2122
            : ...||              .....|.|:|..|.        |:.|:......:..|...|| |
Yeast   486 R-TWKACLPEELRDQDEPTIPVNGRKFFKYPSPIA--------DLLPANATLNDKVPEPTEGA-P 540

  Fly  2123 TTMHKVSGRQEQHQAKMVGRKPRGISAPADATAVHVVTPVAPNKQMLKKRKSRLE---NVLITMK 2184
            |....|..   .:....:.|...|..:.:|....:::.|..|.::      .:::   ..:||
Yeast   541 TAPPLVGA---VYLGPKLERDDLGEYSTSDDCPRYIIRPNDPPEE------GKIDYETGTIIT-- 594

  Fly  2185 LKCLDAQTAQEQP-IDLSYLLSGRGARQRKTQQSSSSSTANST 2226
                |..|....| ::.|..:.....:|.|:..||:..::::|
Yeast   595 ----DTLTTSSMPRVNSSSTIRLPTLKQTKSIPSSNFRSSSNT 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021
		AWS	1340..1388	CDD:197795
		SET_ASH1L	1391..1531	CDD:380951
		Bromo_ASH1	1680..1787	CDD:99955	11/55 (20%)
		PHD_ASH1L	1858..1900	CDD:277023	5/45 (11%)
		BAH_polybromo	1929..2073	CDD:240068	43/167 (26%)
RSC1	NP_011570.1	Bromo_Rsc1_2_I	8..113	CDD:99952	10/46 (22%)
		COG5076	115..463	CDD:227408	78/380 (21%)