back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and Setdb1

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_001157113.1	Gene:	Setdb1 / 84505	MGIID:	1934229	Length:	1308	Species:	Mus musculus

Alignment Length:	1751	Identity:	322/1751 - (18%)
Similarity:	533/1751 - (30%)	Gaps:	642/1751 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 SMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVTTGQY 547
            |:....:|.|:.|..::.|.....||.|.||..:||.:...|........|:..|:..:|
Mouse     9 SLAAAPAAADSAEIAELQQAVVEELGISMEELRQYIDEELEKMDCIQQRKKQLAELETWV----- 68

  Fly   548 FGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSG-VSRMRRRHRRK 611
                  |...:...::.::.:.                 .|...:.|.|.|.. .|::..::
Mouse    69 ------LQKESEVAYVDRLFDD-----------------ASREVTNCESLVKDFYSKLGLQY--- 107

  Fly   612 SFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGK--EKLLADANKLQATLAAPSPAQ 674
               |:.|...::...|||..|...       .||.|:..||.  .:...|....:|..|....||
Mouse   108 ---HDSSSEDEASRPTEIIEIPDE-------DDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQ 162

  Fly   675 QLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGSGSSNGN------------ 727
            .:            :.....:.|:..|:.      |.....|..:|..|.:|:
Mouse   163 DV------------QKFMDAVNKKSSSQD------LHKGTLGQVSGELSKDGDLIVSMRILGKKR 209

  Fly   728 TKRRHKKSQSNDSSSPDDHKLPLK---KRHYLLTPGE-----RPPAEVAFANGKLNA------EA 778
            ||..||.:.....:.....|..:|   |...||:...     .|||:..|...::.|      :.
Mouse   210 TKTWHKGTLIAIQTVGLGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLFVGSRVVAKYKDGNQV 274

  Fly   779 WAAAAAAAKSTASTKSQAQF--------NARSVKSALTPKKRHLLEQPTSVSGAG---------S 826
            |..|...|: |.:.|::.:|        .:...:|.|.|..|.|.:....:..:.         :
Mouse   275 WLYAGIVAE-TPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDSSCRDFIEEYIT 338

  Fly   827 SASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQRRGGAAKQKVSAAK-DLVQ---LQSPAGSY 887
            :..|.|:.:      :..|:|          :|.:..|...|.:|.... .||:   |......:
Mouse   339 AYPNRPMVL------LKSGQL----------IKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEW 387

  Fly   888 PPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNL 952
                ::..|..||....:...:.|.:.|                               |.||.|
Mouse   388 ----IYRGSTRLEPMFSMKTSSASAMEK-------------------------------KQGGQL 417

  Fly   953 LLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAA 1017
            .        .|.....||.|...|...|..|....:.:|.     ||||.:...        ...
Mouse   418 R--------TRPNMGAVRSKGPVVQYTQDLTGTGIQFKPM-----EPLQPIAPP--------APL 461

  Fly  1018 PNPPLDCERVPQAG--EARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEA 1080
            |.|||.    |||.  |:.|:.:|::.::..:.|...     ||.:...|.
Mouse   462 PIPPLS----PQAADTESLESQLAQSRKQVAKKSTSF-----RPGSVGSGH-------------- 503

  Fly  1081 APQPPPKSEPEIRPAKKRG-----RQPKQPVLEEP----PPTPPPQQKKNKMEPNIRLPDGIDPN 1136
             ..|...:..|...|.|.|     |.|...|...|    ||.||             :|.|
Mouse   504 -SSPTSSTLSENVSAGKLGINQTYRSPLASVTSTPASAAPPVPP-------------VPPG---- 550

  Fly  1137 TNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAE----AEAKRLDSIPTE 1197
                            ..|.|....|..|:.    ||......|...||    |..::|..:|
Mouse   551 ----------------PPTPPGPPAPPGPLA----PPAFHGMLERAPAEPSYRAPMEKLFYLP-- 593

  Fly  1198 HDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVK------KTYLVAGLFSNHYKQSLMP 1256
                                     ...|.|.|.::..::      |..|:..|.   |....|.
Mouse   594 -------------------------HVCSYTCLSRIRPMRNEQYRGKNPLLVPLL---YDFRRMT 630

  Fly  1257 PPAKVNKKPGLEE-QVGPASL-LPPPPYCEKYLRRTEMDF---EL----PY-------------- 1298
            ...:||:|.|... ...|..| |......|:||..|..||   |:    ||
Mouse   631 ARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQPFKPFY 695

  Fly  1299 ---DIWWAYTNSKLPTRNVV-----PSWNYRKIR---TNVYAESVRPNLAGFDHPTC--NCKNQG 1350
               ||.:...:..|...|.:     |...|.|.|   ..|:..:....|.|.|   |  .|:::.
Mouse   696 YILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCD---CKDGCRDKS 757

  Fly  1351 EKSC--------------------------LDNCLNRMVYTECSP-SNCPAGEKCRNQKIQRHAV 1388
            :.:|                          |:.||...|| ||:. .||.. ..|.|:.:| |.:
Mouse   758 KCACHQLTIQATACTPGGQVNPNSGYQYKRLEECLPTGVY-ECNKRCNCDP-NMCTNRLVQ-HGL 819

  Fly  1389 APGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLV 1453
            ...::.|.|.:||||:|....||||:::..|.|:::|: :|..:
Mouse   820 QVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTD-DFADK--------------------- 862

  Fly  1454 IDGQRMGSDCRFVN--HSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQ 1516
             :|..|| |..|.|  |                          ||..|.....|...:...|:..
Mouse   863 -EGLEMG-DEYFANLDH--------------------------IESVENFKEGYESDVPTSSDSS 899

  Fly  1517 PCRCNTPQCRGVIGGKSQRVKPLPAVEAKPSGEGLSGRNGRQRKQKAKKHAQRQAGKDISSAVAV 1581
                                    .|:.|...:|.||..            ..:...|.||....
Mouse   900 ------------------------GVDMKDQEDGNSGSE------------DPEESNDDSSDDNF 928

  Fly  1582 AKLQPLSEKEKKLVRQFNTFLV-RNFEKIRRCKAKRASDAAATASS----PALGTTNGDIPGRRP 1641
            .|.:           .|:|..| |::...|:.:.::.::.:...|.    |.||..:..|
Mouse   929 CKDE-----------DFSTSSVWRSYATRRQTRGQKENELSEMTSKDSRPPDLGPPHVPI----- 977

  Fly  1642 STPSSPSLAAQISALCSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDLLTTVS 1706
              |||.|:..     |:|              |..|:..|..|.....|:::.....:|
Mouse   978 --PSSVSVGG-----CNP--------------PSSEETPKNKVASWLSCNSVSEGGFAD------ 1015

  Fly  1707 SKKKKPIKTTL--SGKLG------STAATSKVEFRSIQAQVEQGHYKTPQEFDD---HMQQLFVE 1760
            |..:...||:.  .|:.|      ..|:||.:.|:      ::|..|.|::.|.   :...:..|
Mouse  1016 SDSRSSFKTSEGGDGRAGGGRGEAERASTSGLSFK------DEGDNKQPKKEDPENRNKMPVVTE 1074

  Fly  1761 AKQQHGDD-----EGKEKALQSLKDSYEQQKIASYVQLVEILGDSESLQSFKPKEVL---SSEEE 1817
            ..|.||.:     ||..::...:          |.:|...::..::|    .|.::|   ||.|.
Mouse  1075 GSQNHGHNPPMKSEGLRRSASKM----------SVLQSQRVVTSTQS----NPDDILTLSSSTES 1125

  Fly  1818 PGKIAVKKSPGAKERDSPIVPLKVTPPPLLPIEASPDEDVIRCICGLYKDEGLMIQCSKCMVWQH 1882
            .|:....:.|.|....:..|                |.|.|:.|
Mouse  1126 EGESGTSRKPTAGHTSATAV----------------DSDDIQTI--------------------- 1153

  Fly  1883 TECTKADIDADNYQCERCEPREVDREIPLEEFTEEGHRYYLSLMRGDLQVRQGDAVYVLRDIPIK 1947
                .:..|.|:::.::.......|::.::.                   .:|.|:.....|.||
Mouse  1154 ----SSGSDGDDFEDKKNLSGPTKRQVAVKS-------------------TRGFALKSTHGIAIK 1195

  Fly  1948 D------ESGKVLPTKKHTYETIGAIDYQE-CDIFRVEHLWKNELGKRFIFGHHFLRPH----ET 2001
            .      :.|:..|.:|:|.:   ..|.:| |.|  ::...:..||:   :.:|...|:    ..
Mouse  1196 STNMASVDKGESAPVRKNTRQ---FYDGEESCYI--IDAKLEGNLGR---YLNHSCSPNLFVQNV 1252

  Fly  2002 F---HE---PSRRFYPNEVVRVSL-------YEVVPIELVIGR-----CWVLDRTTFCKGR 2044
            |   |:   |...|:.::.:|...       |||..:|   |:     |..::    |:||
Mouse  1253 FVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVE---GKELLCCCGAIE----CRGR 1306

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.