Protein Alignment ash1 and EFS

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_177854.6
• Gene: EFS / 844066
• AraportID: AT1G77300
• Length: 1805
• Species: Arabidopsis thaliana
• Alignment Length: 2025
• Identity: 400/2025 - (19%)
• Similarity: 673/2025 - (33%)
• Gaps: 657/2025 - (32%)

  Fly   489 SADDTVE----------------DQDIL-QLAGLSLGQSSEESNEYISKPSL-------KSLPTT 529
            :||||.|                |.|:| ....|..|:.|:::|  :|..|:       |..|..
plant    99 NADDTQEQGVVSGELEQSQELICDTDLLVNCNKLDDGKESQDTN--VSLVSIFSGSMQEKEAPQA 161

  Fly   530 SASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMMNQRKETPAPSKSSCKIKSRRSSAASMC 594
            ...:.||        |.....|||...|.     |..:|...|.....:::..||.....:..:.
plant   162 KEDEGYG--------GTTLPIGGSGIDTE-----STFVNDAPEQFESLETTKHIKPDEVESDGIS 213

  Fly   595 SSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLAD 659
            ..:..|         .|...:..|.::|:....:|. ::.:|:....:.|..:.|.|..|..|.|
plant   214 YRFDDG---------GKEGRNGPSSDLDTGSSDDIS-LSQSFSFPDSLLDSSVFGCSATESYLED 268

  Fly   660 ANKLQAT---LAAPSPA--QQLTLNGGGPAS------TLSKPLKRGLKKRKLSEPLVDFAMLSAS 713
            |..::..   :.:||.|  :.|..:.||..|      |:::.:...||..:......|.::::
plant   269 AIDIEGNGTIVVSPSLAITEMLNNDDGGLCSHDLNKITVTETINPDLKLVREDRLDTDLSVMN-- 331

  Fly   714 ASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANG---KLN 775
                            .:..|:...||||                  |...|.::..||   .|.
plant   332 ----------------EKMLKNHVGDSSS------------------ESAVAALSMNNGMAADLR 362

  Fly   776 AEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVSGAGSSASN-----SPLRI 835
            ||.::.::...:.|...::.:.....|:          :...|.:....|....|     .||||
plant   363 AENFSQSSPIDEKTLDMEANSPITDSSL----------IWNFPLNFGSGGIEVCNPENAVEPLRI 417

  Fly   836 VVDNNSISGGKLLDISPSSLC-----SLKQQRRGG----------------AAKQKVSAAKDL-- 877
            |.||..| ||::...|.|..|     |.:::.|.|                .:.:|..:.:|:
plant   418 VDDNGRI-GGEVASASGSDFCEAGMSSSRRKARDGKQCKVVQTKTSARHLRKSSRKKQSERDIES 481

  Fly   878 -----------------------------VQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVI 913
                                         :.|||....|..|...||      |.....||....
plant   482 IFKCSKQKRSSLLKTSRSSEWGLPSKTTEIFLQSNNIPYDGPPHHEP------QRSQGNLNNGEH 540

  Fly   914 TKA-----------EVESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLL-------------- 953
            .::           .:::...|.|.:|....|..||..:...:.|..||.|
plant   541 NRSSHNGNVEGSNRNIQASSGSCLRLKVKFGKSGGQNPLNITVSKVSGNSLPGNGIVKAGTCLEL 605

  Fly   954 -------------------LKRKRKKINRTGF----PTVRRKK---------RKVSVEQQTTAVI 986
                               |..|...:.:..:    .::|.||         |||..:     |:
plant   606 PGSAHFGEDKMQTVETKEDLVEKSNPVEKVSYLQSSDSMRDKKYNQDAGGLCRKVGGD-----VL 665

  Fly   987 DEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERV--PQAGEARETFVARTNQKAPRLS 1049
            |        ||..|.|:|...               :|||.  .|:.:|..:..:......|. |
plant   666 D--------DDPHLSSIRMVE---------------ECERATGTQSLDAETSPDSEVINSVPD-S 706

  Fly  1050 VVALERLQRPQTPARGRPRGRKPKNR----EQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVLEEP 1110
            :|.:|..:.........|.....|||    |....|.:.|.::...:.|..|:.:.||
plant   707 IVNIEHKEGLHHGFFSTPEDVVKKNRVLEKEDELRASKSPSENGSHLIPNAKKAKHPK------- 764

  Fly  1111 PPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQP---------- 1165
              :.....||.|.:.:....||....::..    :::||:|  .|...::....|
plant   765 --SKSNGTKKGKSKFSESAKDGRKNESHEG----VEQRKSL--NTSMGRDDSDYPEVGRIESHKT 821

  Fly  1166 -------------VTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEH-----------DPLPAS-- 1204
                         .|...|..::...:..:|...|    ||..||.           ..:|||
plant   822 TGALLDADIGKTSATYGTISSDVTHGEMVVDVTIE----DSYSTESAWVRCDDCFKWRRIPASVV 882

  Fly  1205 ----ESH-----NPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAK 1260
                ||.     |...:.:|.||:|.|                       .||.          :
plant   883 GSIDESSRWICMNNSDKRFADCSKSQE-----------------------MSNE----------E 914

  Fly  1261 VNKKPGLEEQVGPASLLPPPPY-CEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIR 1324
            :|::.|:.:....|       | |:...|..|.:           ..||..|......  ::.|:
plant   915 INEELGIGQDEADA-------YDCDAAKRGKEKE-----------QKSKRLTGKQKAC--FKAIK 959

  Fly  1325 TNVYAESVRPNLAGFDHPTCNCK--NQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHA 1387
            ||.:....|.:....:...|:||  ..|...|.:.|||||:..||....||||:.|.||:.|:..
plant   960 TNQFLHRNRKSQTIDEIMVCHCKPSPDGRLGCGEECLNRMLNIECLQGTCPAGDLCSNQQFQKRK 1024

  Fly  1388 VAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMAS-IYLNDTHHYCLHLDGG 1451
            ... .|||.:..||:|:|....:.:|.:::||||||:..:.::.|... .:....|.|.:.|:|.
plant  1025 YVK-FERFQSGKKGYGLRLLEDVREGQFLIEYVGEVLDMQSYETRQKEYAFKGQKHFYFMTLNGN 1088

  Fly  1452 LVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQ 1516
            .|||....|:..||:||||||||..:||.|||...:.:|:.:.:::|:|||:|||:.....:..:
plant  1089 EVIDAGAKGNLGRFINHSCEPNCRTEKWMVNGEICVGIFSMQDLKKGQELTFDYNYVRVFGAAAK 1153

  Fly  1517 PCRCNTPQCRGVIGG------------KSQRVKPLPAVEAKPSGEGLSGRNGR--------QRKQ 1561
            .|.|.:..|||.|||            ..:....|..::...||||:.|...|        |..|
plant  1154 KCYCGSSHCRGYIGGDPLNGDVIIQSDSDEEYPELVILDDDESGEGILGATSRTFTDDADEQMPQ 1218

  Fly  1562 KAKK----------HAQRQAG---------------------KDISSAVAVAKLQPLSEKEKKLV 1595
            ..:|          :.|.|:.                     |::||.:::..:|.....||
plant  1219 SFEKVNGYKDLAPDNTQTQSSVSVKLPEREIPPPLLQPTEVLKELSSGISITAVQQEVPAEK--- 1280

  Fly  1596 RQFNTFLVRNFEKIRRCKAKRASDAAATASSPALGTTNGD-------------IPGRRPSTPSSP 1647
                             |.|..|..:::.|..:.|.||.|             :|..||...:|.
plant  1281 -----------------KTKSTSPTSSSLSRMSPGGTNSDKTTKHGSGEDKKILPRPRPRMKTSR 1328

  Fly  1648 SLAAQISALCSPRNIKTRGLTQAVHDPELEKMAKMAVVLRDICSAMETLKMSDLLTTVSSKKKKP 1712
            |..:      |.|:  ..|:...|:..::..:.|:                          :::|
plant  1329 SSES------SKRD--KGGIYPGVNKAQVIPVNKL--------------------------QQQP 1359

  Fly  1713 IKTTLSGKLGSTAATSKVEFRSIQAQVEQGHYKTPQEFDDHMQQLFVEAKQQHGDDEG--KEKAL 1775
            ||:..|.|:..:..|.:.:...:...| .|..|.......:::.|.:.|..:..|:||  ..:.|
plant  1360 IKSKGSEKVSPSIETFEGKLNELLDAV-GGISKRRDSAKGYLKLLLLTAASRGTDEEGIYSNRDL 1423

  Fly  1776 QSLKDSYEQQKIASYVQLVEILGDSESLQ-----------SFKP----KEVLSSEEEPGKIAVKK 1825
            ..:.|:..:.|..|.  ||:|: :...||           .||.    :::|...|   .:|.:|
plant  1424 SMILDALLKTKSKSV--LVDII-NKNGLQMLHNIMKQYRGDFKRIPIIRKLLKVLE---YLATRK 1482

  Fly  1826 SPGAKERDSPIVPLK--VTPPPLLPIEA---------SPDEDVIRCICGLYKDEGLMIQCSKCMV 1879
                      |:.|:  :..||...:|:         ..|:..:..|...::|..:.....|  .
plant  1483 ----------ILALEHIIRRPPFAGMESFKDSVLSFTEHDDYTVHNIARSFRDRWIPKHFRK--P 1535

  Fly  1880 W-----QHTECTKADID-------ADNYQCERCEPREVDREI-------PLEEFTEEGHRYYLSL 1925
            |     :.:|..::.|:       ...|..:...|.|....:       |......||:    |.
plant  1536 WRINREERSESMRSPINRRFRASQEPRYDHQSPRPAEPAASVTSSKAATPETASVSEGY----SE 1596

  Fly  1926 MRGDLQVRQGDAVYVLRDIPIKDESGKVLP-TKKHTYETIGAIDYQE---------C-DIFRVEH 1979
            ....|....|.......|.|.|.:..:::. ..:.|.||.|..|.|:         | |:
plant  1597 PNSGLPETNGRKRKSRWDQPSKTKEQRIMTILSQQTDETNGNQDVQDDLPPGFSSPCTDV----- 1656

  Fly  1980 LWKNELGKRFIFGHHFLRPHETFHEPSRRFYPNEVVRVSLYEVVPIELV--IGRCWVLDRTTF-- 2040
                              |.....:|.::|    :.|:.:...:|:.:|  .|.....|.||:
plant  1657 ------------------PDAITAQPQQKF----LSRLPVSYGIPLSIVHQFGSPGKEDPTTWSV 1699

  Fly  2041 CKGRPMECNDEDHCY-ICELRVDKTARFFSKAKANHPACTKSYAFRKFPEKI----KISKSYAPH 2100
            ..|.|.        | ...|.......||  ||.|..||:.|.....:..:|    .::.|.||
plant  1700 APGMPF--------YPFPPLPPVSHGEFF--AKRNVRACSSSMGNLTYSNEILPATPVTDSTAP- 1753

  Fly  2101 DVDPSLLKTRKQKT-ELDVGAGPTTMHKVSGRQEQHQAKMVGRKPRGISAPADATAVHVVTPVAP 2164
                    |||::. ..|:|   ||..:     :|.|:.....:..|....|:       :|:..
plant  1754 --------TRKRELFSSDIG---TTYFR-----QQKQSVPPWLRNNGGEKTAN-------SPIPG 1795

  Fly  2165 NKQMLKKRKS 2174
            |..:.||..|
plant  1796 NLTLEKKLNS 1805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	54/313 (17%)
		AWS	1340..1388	CDD:197795	20/49 (41%)
		SET_ASH1L	1391..1531	CDD:380951	52/140 (37%)
		Bromo_ASH1	1680..1787	CDD:99955	17/108 (16%)
		PHD_ASH1L	1858..1900	CDD:277023	7/53 (13%)
		BAH_polybromo	1929..2073	CDD:240068	30/159 (19%)
EFS	NP_177854.6	zf-CW	865..910	CDD:462181	11/67 (16%)
		AWS	975..1025	CDD:197795	20/49 (41%)
		SET_SETD2	1025..1167	CDD:380949	51/142 (36%)