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Protein Alignment ash1 and SETDB2

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	NP_114121.2	Gene:	SETDB2 / 83852	HGNCID:	20263	Length:	719	Species:	Homo sapiens

Alignment Length:	831	Identity:	156/831 - (18%)
Similarity:	267/831 - (32%)	Gaps:	306/831 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   855 LCSLKQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVE 919
            |.||||:.:.|:|..     |:.:|                        .:..:||:.|
Human    32 LQSLKQKIKDGSATN-----KEYIQ------------------------AMILVNEATI------ 61

  Fly   920 SPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTA 984
              :.|:..||..::|||..        ::...:.:.:|.::.....||:...:.   |..:..|.
Human    62 --INSSTSIKGASQKEVNA--------QSSDPMPVTQKEQENKSNAFPSTSCEN---SFPEDCTF 113

  Fly   985 VIDEHEPEFDPDDEPLQSLRETRSSNNVNVQA----------------APNP---PLDCERVPQA 1030
            :..|::.....:|: :...||..||:|::.|:                ..||   |:.|.
Human   114 LTTENKEILSLEDK-VVDFREKDSSSNLSYQSHDCSGACLMKMPLNLKGENPLQLPIKCH----- 172

  Fly  1031 GEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEIRPA 1095
            .:.|.   |:||..:..|.|            :...|.||..:|.|:.
Human   173 FQRRH---AKTNSHSSALHV------------SYKTPCGRSLRNVEEV----------------- 205

  Fly  1096 KKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKE 1160
                   .:.:||              .|.|....|    |.:|:..::|.|       ..||::
Human   206 -------FRYLLE--------------TECNFLFTD----NFSFNTYVQLAR-------NYPKQK 238

  Fly  1161 KPVQPVT----VEEIP------------PEI---------------------------------- 1175
            :.|..|.    ||.:|            |:.
Human   239 EVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDIT 303

  Fly  1176 ---------------PVSQEEIDAEAEAKRLD-SIPT---------------------EHDPLPA 1203
                           |:|.::|....:.|||. .|||                     :|.|...
Human   304 KCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVR 368

  Fly  1204 SESHNPGPQDYASCSESSEDKASTTSL---RKLSK--VKKTY----------LVAGLFSNHYKQS 1253
            .:......:.:........|:.:...:   |.||:  .:|:|          .:..:||...|..
Human   369 LQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDENGRDENTMKNIFSKKRKLE 433

  Fly  1254 LMPPPAKVNKKP-GLEEQVGPASLLPPPPYCEKYLRR-TEMDFELPYDIWWAYTNSKLPTRNVVP 1316
            :.....:|...| |||.....|.....||   |:... .|:..|..||     ..|::...:|:.
Human   434 VACSDCEVEVLPLGLETHPRTAKTEKCPP---KFSNNPKELTVETKYD-----NISRIQYHSVIR 490

  Fly  1317 ---------SWNYRKIRTNVYAESVRP-NLAGFDHPT--CNCKNQG-EKSCLDNCL-----NRMV 1363
                     ..|.:|:.. |.:|||.| :..||..|.  .|.|.:| :|....|.:     |.::
Human   491 DPESKTAIFQHNGKKMEF-VSSESVTPEDNDGFKPPREHLNSKTKGAQKDSSSNHVDEFEDNLLI 554

  Fly  1364 ---------YTECSP--SNCPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYIL 1417
                     |.|.:|  |.|.......||.|::     .:|          |:.:.| .:|....
Human   555 ESDVIDITKYREETPPRSRCNQATTLDNQNIKK-----AIE----------VQIQKP-QEGRSTA 603

  Fly  1418 EYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGG--LVIDGQRMGSDCRFVNHSCEPNCEMQKWS 1480
            ....:|..::|    :.|...|.:.......:.|  .::|..:.|:..||:||||.||..:|...
Human   604 CQRQQVFCDEE----LLSETKNTSSDSLTKFNKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVF 664

  Fly  1481 VNGLSR----MVLFAKRAIEEGEELTYDYNFSLFN-PSEGQPCRCNTPQCR 1526
            |...:|    :..|..|.::...|||:||.:.... |.:...|:|...:||
Human   665 VETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCR 715

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.