Protein Alignment ash1 and SDG25

DIOPT Version :10

• Sequence 1: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Sequence 2: NP_001318731.1
• Gene: SDG25 / 834246
• AraportID: AT5G42400
• Length: 1388
• Species: Arabidopsis thaliana
• Alignment Length: 1661
• Identity: 331/1661 - (19%)
• Similarity: 545/1661 - (32%)
• Gaps: 533/1661 - (32%)

  Fly   107 KRKKLAS---------SSGISKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQA 162
            :|||:::         ..|: .||.||.|.:.....:|.||..||                   |
plant    18 RRKKVSALEPNYFGSMCMGV-YSDDVSISAREVAQDYSCDSCGDL-------------------A 62

  Fly   163 AQSASKPTLD--IGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQD 225
            ..|::....|  .|:.|:       ::...:..|.........||...:..||::|.| :.....
plant    63 TVSSACCNFDELCGLDSA-------LEMGCRSNEDCRAGQEASGSGIASGLDKSVPGY-TMYASG 119

  Fly   226 FM---EKTQMLGQTVNAKLAEEKVAKAKEETLV---------QTAVPRKRRGRPKKVVPTVPAPG 278
            :|   ::.||.|.....:|.:........|.|:         ..:||.|.    .|..|...|.|
plant   120 WMYGNQQGQMCGPYTQQQLYDGLSTNFLPEDLLVYPIINGYTANSVPLKY----FKQFPDHVATG 180

  Fly   279 NSGPAINESADSGVISTTSTTQSTTPS--------PKMQNENAVPTGSL-------PIASSSKPK 328
            .:      ...:|:||...:..|..||        .::|.|:|.....|       |..||:...
plant   181 FA------YLQNGIISVAPSVTSFPPSSSNATVHQDEIQTEHATSATHLISHQTMPPQTSSNGSV 239

  Fly   329 IDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVNKKFRLRSMSVG 393
            :|...|:                 ..::|...:..|...|.    ..|..:|
plant   240 LDQLTLN-----------------HEESNMLASFLSLGNEH----ACWFLVD------------- 270

  Fly   394 AASGTGAS---TTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRS 455
               |.|.:   .:|.......:.|||||...:|              |...|.|..|.:.:....
plant   271 ---GEGRNHGPHSILELFSWQQHGYVSDAALIR--------------DGENKLRPITLASLIGVW 318

  Fly   456 RAKSCGYRSDCKE--SG---------------KSGLRMRRKRRASMLLKSSADDTVED--QDILQ 501
            |.| || .::|.|  :|               :||: |:..|||.:      |:.:..  .|.|:
plant   319 RVK-CG-DANCDEPVTGVNFISEVSEELSVHLQSGI-MKIARRALL------DEIISSVISDFLK 374

  Fly   502 LAGLSLGQSSEESNEYISKPSLKSLPTTSASKKYGE--INRYVTTGQYFGRGGSLSATNPDNFIS 564
                     :::|:|:     |||.|.|||.:....  ||...:........|..:..|.....|
plant   375 ---------AKKSDEH-----LKSYPPTSAVESISSRVINAEKSVVSNTESAGCKNTMNEGGHSS 425

  Fly   565 KMMNQRKETPAPSKSSCKIKSRRSSAASMC----------------------------------- 594
            ......|.|    ||...|::.::|.:::|
plant   426 IAAESSKYT----KSVGSIENFQTSCSAVCRTLHHHCMQIMWNAVFYDTVATHSSCWRKNKIWFR 486

  Fly   595 SSYVSGVSRMRRRHRR-----KSFSHNKSLNID---SKLLTEIEIITSTFNSRCR-IQDDRLTGS 650
            ||.:|.|:..:..|.:     :|| .:.:..:|   ||.....|...:|..:|.| :..|    :
plant   487 SSDISTVNYCKGSHTKYSDKPESF-ESFTCRVDSSSSKTAYSDEFDLATNGARVRGLSSD----T 546

  Fly   651 SGKEKLLAD-----ANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAML 710
            .|.|.::|.     .|:|..:|..........|...|..:|.|.  .|..|..:.:.|     .|
plant   547 YGTESVIASISEHVENELFLSLKTHLTDYTSILIKDGANNTTSS--ARDGKMHEENPP-----SL 604

  Fly   711 SASASGTPNGSGSS---NG---------------NTKRRHKKSQSNDSSSPDD------------ 745
            ..|.....|..|||   ||               :::|..::.:|::..:.:|
plant   605 QGSFREQYNLEGSSKKKNGLNVVPAKLRFSNDFSDSQRLLQEGESSEQITSEDIIANIFSTALET 669

  Fly   746 HKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPK 810
            ..:|:......|...|.||..   ....:|...........:|..|......:    |..||..:
plant   670 SDIPVNDELDALAIHEPPPPG---CESNINMPCLRYKYQPVRSKESIPEIKAY----VSMALCRQ 727

  Fly   811 KRH---------------LLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLL--DISPSSLCSL 858
            |.|               |.|...|:.|:...:....|.:..........||:  :||..:...|
plant   728 KLHNDVMRDWKSLFLKCYLNEFLASLKGSHQVSRKETLALKKRKTVTRNKKLVQSNISNQTAEKL 792

  Fly   859 KQQRRGGAAKQKVSAAKDLVQLQSPAGSYPPPGVFE---PSVELEIQIPLSKLNESVITKAEVES 920
            ::...|.:.|..|..:|.|      :.|:....|.:   ||::|.::.|    ::..:...:...
plant   793 RKPCVGASEKVLVKRSKKL------SDSHSMKEVLKVDTPSIDLSVRKP----SQQKMRNTDRRD 847

  Fly   921 PLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAV 985
            ..:    ||:.||           |||           :|:.:..|..|...|.:
plant   848 HCI----IKDATK-----------LHK-----------EKVGKDAFSKVICDKSQ---------- 876

  Fly   986 ID-EHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVP-QAGEARETFVARTNQKAPRL 1048
             | |.|.||| |...:..||....:....::...|....||.:. .|.|:.||...:.::::  |
plant   877 -DLEMEDEFD-DALLITRLRRISRNKTKELRECRNAAKSCEEISVTAEESEETVDCKDHEES--L 937

  Fly  1049 SVVALERLQRPQTPARGRPRGRKPKN----REQAEAAPQPPPKSEPEI----------------- 1092
            |....:::::..|..      .|.||    |::...:.....||..||
plant   938 SNKPSQKVKKAHTSK------LKRKNLSDARDEGTKSCNGAVKSFTEISGKEGDTESLGLAISDK 996

  Fly  1093 -----------RPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLK 1146
                       :.|.|.|:.     :..|...||            ||.:|.......:|.|..|
plant   997 VSHQNLSKRRKKDAAKNGQD-----MSNPTGNPP------------RLAEGKKFVEKSACSISQK 1044

  Fly  1147 RRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGP 1211
            .||:.::....:|.:                ..|:|......:||....|:.:.....|.::...
plant  1045 GRKSSQSSILKRKHQ----------------LDEKISNVPSRRRLSLSSTDSEDAVIKEDYDVRN 1093

  Fly  1212 QDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHY----------------KQSLMPPPAK 1260
            ::...|..|  ||.......||.:.:|.      .:.|.                |...:.|..|
plant  1094 EEKLPCHTS--DKLQKVGPNKLIRRRKP------LAKHTTERSPIKDLSVDDGRPKPIALKPLEK 1150

  Fly  1261 VNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSWNYRKIRT 1325
            ::.||.                      :.::...:|        .|....|..:..|::.....
plant  1151 LSSKPS----------------------KKKLFLSIP--------KSDGCARTSINGWHWHAWSL 1185

  Fly  1326 NVYAESVRPNLAGFDHPTC-NCKNQGEKSCL-DNCL----NRMVYTECSPSNCPAGEKCRNQKIQ 1384
            ...||. |..:.|   .:| :.::.|.||.| .|.|    ||              .|.||..
plant  1186 KASAEE-RARVRG---SSCVHMQHFGSKSSLTQNVLSARTNR--------------AKLRNLL-- 1230

  Fly  1385 RHAVAPGVE--------------RFMTAD-KGWGVRTKLPIAKGTYILEYVGEV-------VTEK 1427
              |.|.|.:              ||..:. ..||:....||....:::|||||:       :.|:
plant  1231 --AAADGADVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRER 1293

  Fly  1428 EF-KQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFA 1491
            :: |..:.|.||       ..||.|.|:|..:.|...||:||||||||..:..||.|..::.::|
plant  1294 QYEKMGIGSSYL-------FRLDDGYVLDATKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYA 1351

  Fly  1492 KRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRG 1527
            ||.|:.|||::|:|.|.|  ..:..||.|..|:|||
plant  1352 KRHIDAGEEISYNYKFPL--EDDKIPCNCGAPKCRG 1385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	52/311 (17%)
		AWS	1340..1388	CDD:197795	12/53 (23%)
		SET_ASH1L	1391..1531	CDD:380951	54/160 (34%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
SDG25	NP_001318731.1	SET_SETD1	1237..1384	CDD:380946	50/155 (32%)