DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and KMT2D

DIOPT Version :9

Sequence 1:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:XP_011537072.1 Gene:KMT2D / 8085 HGNCID:7133 Length:5556 Species:Homo sapiens


Alignment Length:1986 Identity:362/1986 - (18%)
Similarity:626/1986 - (31%) Gaps:626/1986 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 QNETAAAKVLETQRAQESGSENEETDSITDQSSQSKSIKS------ATQFSVQRSDTDGLRMRIS 63
            |....|.|:.:.|:.|:.........:|..|..|...:::      ..|..:..|...||.::..
Human  3729 QRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPSSHQGLLVQQL 3793

  Fly    64 AIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKK 128
            :.:|..|......|.:...:..|...:...:..:|.|          |.:.|.:..|.::::..:
Human  3794 SPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQV----------LMTQSRVLSSPQLAQQGQ 3848

  Fly   129 SQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSAS-KPTLDIGISSSDNEL---------P 183
            ..:......::.....:.|||:.....||.:.|:..|.| :|.|......|..:|         .
Human  3849 GLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQ 3913

  Fly   184 NLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAEEKVAK 248
            .|.|...::::.  :....:...::..:.:.|.|.|...||...::.|...|....:..:::..:
Human  3914 QLQQQQQQQLQQ--QQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQ 3976

  Fly   249 A-----KEETLVQTAVPRKRR-----GRPKKVVPTVPAPGNSGPAI------NESADSGVISTTS 297
            .     :..||:.....::::     |.|.|.:....:||..||.:      ..:.|..|.|   
Human  3977 QMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSS--- 4038

  Fly   298 TTQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYL--DKRMYATERVLYPPPRSKRRQNNKKT 360
               ..|..|.......:..|:.|.:.:::|......|  |.::...:....|.|.|         
Human  4039 ---EATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSS--------- 4091

  Fly   361 ACSSSNKEELQLDPLWREIDVNKKFRL-----RSMSVGAASGTGASTTICSKVLAAKSGYVSDYG 420
                     |||.|         ..||     :.:|:...:|.|:...:       .||..|:..
Human  4092 ---------LQLQP---------PLRLPGQQQQQVSLLHTAGGGSHGQL-------GSGSSSEAS 4131

  Fly   421 SVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCG------------------------ 461
            ||.|..:..:.:.|.:..:..::....:..|..|....:.|                        
Human  4132 SVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPT 4196

  Fly   462 -------------------YRSDCKESGKSGLRMRRKRRASMLLKSS------ADDTVEDQDIL- 500
                               :.|..::.....|.|:|:.:.|..::.:      ...|...|.:| 
Human  4197 VGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLG 4261

  Fly   501 ---QLAG------------------------------LSLG------------QSSEESNEYISK 520
               ||.|                              ||.|            .|.:|.......
Human  4262 CQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQL 4326

  Fly   521 PSLKS-LPTTS--------ASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKMM------NQR 570
            ||..| |||.:        ..|..|.     |.....||....:|...|...||.:      :..
Human  4327 PSPSSQLPTEAQLPPTHPGTPKPQGP-----TLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNL 4386

  Fly   571 KETPAPSKSSC------KIKSRRSSAASMCS--------SYVSGVSRMRRRHRRKSFSHNKSLN- 620
            .||..|.:||.      ::..:....||..|        ....|...::|....:......:.| 
Human  4387 AETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPIGAPGTSNH 4451

  Fly   621 -------------IDSKLLTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADAN----------- 661
                         :..|||              |.::.:|:...|.|.|.|:.|           
Human  4452 LLLAGPRSEAGHLLLQKLL--------------RAKNVQLSTGRGSEGLRAEINGHIDSKLAGLE 4502

  Fly   662 -KLQATLA-----------APSP-------------AQQLTLNGGGPAS-TLSKPLKRGLKKRKL 700
             |||.|.:           .|.|             .::|....|..|| .|.|.||:.|....|
Human  4503 QKLQGTPSNKEDAAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPL 4567

  Fly   701 SEPLV--DFAMLSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSPDDHKLPLKKRHY-------- 755
            :||.:  :|::.:...||.|     .||.::.|.........:.||.:...|.|.:.        
Human  4568 TEPAITANFSLFAPFGSGCP-----VNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPS 4627

  Fly   756 LLTPGERPPAEVAFANGKLNAEAWAA----AAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLE 816
            .|.|...|..:....||...:|....    ||:|..|..:.:..::..:..:.:|| |...|  .
Human  4628 SLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERALRDTSEVKSLDLLAAL-PTPPH--N 4689

  Fly   817 QPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCSLKQQR----RGGAAKQKVSAAKDL 877
            |...|.......|:||..||..:           ||.|:...:..|    ..|..:|:..|...:
Human  4690 QTEDVRMESDEDSDSPDSIVPAS-----------SPESILGEEAPRFPHLGSGRWEQEDRALSPV 4743

  Fly   878 VQLQSPAGSYP------PPGVF-------------------EPSVELEIQIPLSK-LNESVITKA 916
            :.| .|..|.|      |.|..                   |.||.|.:....:| ||..::..|
Human  4744 IPL-IPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVA 4807

  Fly   917 EV--------------ESPLLSALDIKEDTKKEVG--QRVVETLLHKTGGNLLLKRKRKKINRTG 965
            |:              |||..:..:.|:...:..|  ::.:|.....||.:.|   |:......|
Human  4808 ELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWL---KQFDAVLPG 4869

  Fly   966 FPTVRRKKRKVSVEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQA 1030
            : |::.:...:|:.:|.:           |..||......|.:.:|::|:....||      |:.
Human  4870 Y-TLKSQLDILSLLKQES-----------PAPEPPTQHSYTYNVSNLDVRQLSAPP------PEE 4916

  Fly  1031 GEARETFVARTNQKAPRLSVVAL--ERLQRPQTP-----------ARGRPRGRKPKNREQAEAAP 1082
            .....:.:|.:....|...:|.|  |.|..|..|           ||.:||.|.|   |:.|.:.
Human  4917 PSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRARPP---EEGEDSR 4978

  Fly  1083 QPPPKSEPEIRPAKKR---------GRQPKQPVLEE----------PPPTP-------------- 1114
            .|..|....:|..:.|         |||..:..:.|          |...|              
Human  4979 PPRLKKWKGVRWKRLRLLLTIQKGSGRQEDEREVAEFMEQLGTALRPDKVPRDMRRCCFCHEEGD 5043

  Fly  1115 ----PPQQKKN-------------------------KMEPNIRLPDGI----------------- 1133
                .|.:..|                         .|...:.|..|:                 
Human  5044 GATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGATSSCN 5108

  Fly  1134 ---DPNT-NFSCKIRLK----RRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKR 1190
               .||. :|:|.||.|    :.|.:.......|....|.::...:...:.:.::|:      |:
Human  5109 RMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSFAVFRRVYIERDEV------KQ 5167

  Fly  1191 LDSIPTEHD-------------------PLPASESHNPG---PQDYAS----------------- 1216
            :.||....:                   |...::.|:..   |..|.:                 
Human  5168 IASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRRCCYR 5232

  Fly  1217 CSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQS----LMPPPAKVNKKPGL---------- 1267
            ||....:......:    ||.:..|...:|::...|:    ::.|.|.:.|:..:          
Human  5233 CSIGENNGRPEFVI----KVIEQGLEDLVFTDASPQAVWNRIIEPVAAMRKEADMLRLFPEYLKG 5293

  Fly  1268 EEQVG--------PASLLPPPPYCEKYLRRTEMD--FELPYDI---WWAYTNSKLPTRNVVPSWN 1319
            ||..|        .|..||....|:.||.|....  .|||..|   ..|.:..|:.|       :
Human  5294 EELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPKILT-------H 5351

  Fly  1320 YRKIRTNVYAESVRPNLAGFDHP-TCNCKNQGEKSCLDNCLNRMVY--TECSPSNCPAGEKCRNQ 1381
            |:::.|::.:.....||.   .| |.|..:..:           .|  |....:|.|..::..:.
Human  5352 YKRVFTSIISFDPHNNLM---RPHTLNSTSMSK-----------AYQSTFTGETNTPYSKQFVHS 5402

  Fly  1382 KIQRHAVAPGVERFMTADK-----------GWGVRTKLPIAKGTYILEYVGEVV-------TEKE 1428
            |..::      .|..|..|           |.|:.....:.|.|.::||:|.::       .||.
Human  5403 KSSQY------RRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKI 5461

  Fly  1429 FKQRMASIY---LNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLF 1490
            ::::...||   :|:.|          |||....|...|::||||.|||..:..:.:...::::.
Human  5462 YEEQNRGIYMFRINNEH----------VIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIII 5516

  Fly  1491 AKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCR 1526
            :.|.|.:||||||||.|...:.....||.|....||
Human  5517 SSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCR 5552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 8/50 (16%)
SET 1392..1512 CDD:214614 39/140 (28%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
KMT2DXP_011537072.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157998
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.870

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