DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and EHMT1

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_011517323.1	Gene:	EHMT1 / 79813	HGNCID:	24650	Length:	1301	Species:	Homo sapiens

Alignment Length:	1468	Identity:	299/1468 - (20%)
Similarity:	483/1468 - (32%)	Gaps:	481/1468 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 SKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSD----- 465
            :::|..::...:|.||...|....:..:..:::.||::..::       |.|.:..:..|
Human    26 TELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDAS-------SHANAAKHTQDSARVN 83

  Fly   466 ----------CKESGKSGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYI-S 519
                      ..|:|.|    .|...|:.....:|||.|:...|             .||.|| :
Human    84 PQDGTNTLTRIAENGVS----ERDSEAAKQNHVTADDFVQTSVI-------------GSNGYILN 131

  Fly   520 KPSLKSLP--TTS--ASKKYGEINRYVTTGQYFGRG---------------GSLSATNPDNFISK 565
            ||:|::.|  |||  ||...|...:.:..|...||.               |..||...|
Human   132 KPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLGEGSADTED----- 191

  Fly   566 MMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVS----RMRRRHRRKSFSHNKSLNIDSKLL 626
                 ::.|||.......::|::...|:...:.:...    |..|.|:......||::
Human   192 -----RKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNI------- 244

  Fly   627 TEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATL------AAPSPAQQLTLNGGGP-- 683
                   |.|               |:::||.....|..:|      .|.:.:|...|    |
Human   245 -------SDF---------------GRQQLLPPFPSLHQSLPQNQCYMATTKSQTACL----PFV 283

  Fly   684 -ASTLSKPLKRGL--------KKRKLSEPLVDFAMLSASASGTPNGSGSSNGNTKRRHKKSQS-- 737
             |:.:|:..||.:        ||.|:.:......|..:....|....|..:......|...:|
Human   284 LAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLE 348

  Fly   738 NDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQF---- 798
            .||...|..:|.....|     |....|.....:.:.:.|:.:.|..|.|....::.:.:.
Human   349 MDSDEDDSEELEEDDGH-----GAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTG 408

  Fly   799 ------NARSVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCS 857
                  :...:.|..:.||:.|..:         ..::||.                |.|:.
Human   409 EEEEGGDESDLSSESSIKKKFLKRK---------GKTDSPW----------------IKPAR--- 445

  Fly   858 LKQQRRGGAAKQKVSAAKDLVQLQSPAGS--YPPPG-------VFEPSVELEIQIPLSKLNESVI 913
             |::||   :::|.|.|......:|.|||  ...||       |...|::|.::..||...|.:.
Human   446 -KRRRR---SRKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDSLDLRVKGILSSQAEGLA 506

  Fly   914 TKAEV-------ESPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRR 971
            ...:|       |.||.|.   :.:|.|   .|.:.||    ..|..:..:
Human   507 NGPDVLETDGLQEVPLCSC---RMETPK---SREITTL----ANNQCMATE-------------- 547

  Fly   972 KKRKVSVEQQ----TTAVIDEHEPEFDPDDEPLQSLRETRSSNNVNVQAAPNPP--------LDC 1024
                 ||:.:    |.:|: ::|.....:..||..|.|......|..|..|...        ::|
Human   548 -----SVDHELGRCTNSVV-KYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMEC 606

  Fly  1025 E---------------RV------PQAGE----ARETFVARTNQKAPRLSVVALERLQRPQTPAR 1064
            :               ||      |..||    |:|..:|    ||...|.|         ||..
Human   607 QPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIA----KADTTSTV---------TPVP 658

  Fly  1065 GRPRGRKPKNREQAE--AAPQPPPKSEPEIRPAKK---RGRQPKQPV-LEEPPPTPPPQQKKNKM 1123
            |:.:|...:.|....  :|..||...:.:::.|..   .|..|..|. |..|.|.......|..:
Human   659 GQEKGSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETL 723

  Fly  1124 EPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEE----IDA 1184
            |..:...|...|.     |:|...::...:..|.:.:| |..:.|:.|.|...:..:.    :.|
Human   724 ESALIALDSEKPK-----KLRFHPKQLYFSARQGELQK-VLLMLVDGIDPNFKMEHQNKRSPLHA 782

  Fly  1185 EAEAKRLD----------SIPT----EHDPL-PASESHNPGPQDY---ASCSESSEDKASTTSLR 1231
            .|||..:|          :|.|    :..|| .|:|:::.....|   |......:|...:|.|.
Human   783 AAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLH 847

  Fly  1232 KLSKVKKTYLVAGLFSN--------------------HYK-----QSLMPPPAKVNKKPGLEEQ- 1270
            ..:|.....:|..|.||                    .||     :.|:...:.:|.:.. ||.
Human   848 LAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDN-EENI 911

  Fly  1271 ----------VGPASLLPPPPYCEKYLRRTEMDFEL-------PYD------------------- 1299
                      |..|.:|.... |:.:......|..|       .||
Human   912 CLHWAAFSGCVDIAEILLAAK-CDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEG 975

  Fly  1300 ------------IWWAYTNSKL----------PTRNVVP---SWNYRKIRTN-VYAESVRPNLAG 1338
                        :|.|...||.          |...:|.   :..|.:|... |.|....|..:.
Human   976 ETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSN 1040

  Fly  1339 FDHPTCNCKNQGEKSCLDNCLNRMVY----TECSPSNCPAGE----------------------- 1376
            :.:.:.||......  :|..:..:.|    .:||.|||..|:
Human  1041 YKYVSQNCVTSPMN--IDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPP 1103

  Fly  1377 -------------KCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGTYILEYVGEVVTEKE 1428
                         .|||:.:| :.:...::.:.|.|.|||||:...|..||::.|||||::::.|
Human  1104 LIFECNHACSCWRNCRNRVVQ-NGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSE 1167

  Fly  1429 FKQRMASIYLNDTHH-----YCLHLDGGLVIDGQRMGSDCRFVNHSCEPNCE-----MQKWSVNG 1483
            ...|....||.|..:     ||        ||.:..|:..||:||.||||..     |....:.
Human  1168 ADVREEDSYLFDLDNKDGEVYC--------IDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLR- 1223

  Fly  1484 LSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQ--PCRCNTPQCRGVIGGKSQRVKPLPAVEAKP 1546
            ..|:..|:.|.||.||:|.:||. ..|...:|:  .|||.:|:||                   .
Human  1224 FPRIAFFSTRLIEAGEQLGFDYG-ERFWDIKGKLFSCRCGSPKCR-------------------H 1268

  Fly  1547 SGEGLSGRNGRQRKQKAKKHAQRQAGKDISSAVAVAKL 1584
            |...|:     ||:..|.:.||.....|.|||.|...|
Human  1269 SSAALA-----QRQASAAQEAQEDGLPDTSSAAAADPL 1301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	14/87 (16%)
		SET	1392..1512	CDD:214614	45/129 (35%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
EHMT1	XP_011517323.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840