DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and SUV39H2

DIOPT Version :10

Sequence 1:NP_524160.2 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_001180353.1 Gene:SUV39H2 / 79723 HGNCID:17287 Length:410 Species:Homo sapiens


Alignment Length:377 Identity:89/377 - (23%)
Similarity:137/377 - (36%) Gaps:134/377 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1230 LRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNK--KPGLEEQVGPASLLPPPPYCEKYLRRTEM 1292
            |::.|..|..||      :..|:.....|...||  ||.:.|                       
Human    90 LQQFSNDKHNYL------SQVKKGKAITPKDNNKTLKPAIAE----------------------- 125

  Fly  1293 DFELPYDIWWAYTNSKLPTRNVVPSW----NYRKIRTN-VYAESV------------------RP 1334
                       |...|...|..:..|    |.||.... ::.|:.                  .|
Human   126 -----------YIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAP 179

  Fly  1335 NLAGFDHPTCNCKNQGEKSCLDNCLNRMVYTECSP---------------------------SNC 1372
            .::..:..|..|      ||.| |.    :.:|.|                           |.|
Human   180 GISLVNEATFGC------SCTD-CF----FQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRC 233

  Fly  1373 PAGEKCRNQKIQRHAVAPGVER----FMTAD-KGWGVRTKLPIAKGTYILEYVGEVVTEKEFKQR 1432
            ..|..|.|:.:|:     |.:.    |.|:: :||||:|.:.|.:.::::||||||:|.:| .:|
Human   234 QCGPDCPNRIVQK-----GTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEE-AER 292

  Fly  1433 MASIYLNDTHHYCLHLD---GGLVIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLS----RMVLF 1490
            ....|.|....|...||   ....:|..|.|:...||||||:||.::....::.|.    |:.||
Human   293 RGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALF 357

  Fly  1491 AKRAIEEGEELTYDYNF---------SL-FNPSEGQ---PCRCNTPQCRGVI 1529
            :.|.|..|||||:||..         |: .:|::.:   .|:|....|||.:
Human   358 STRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYL 409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_524160.2 PHA03247 <1018..1281 CDD:223021 12/52 (23%)
AWS 1340..1388 CDD:197795 14/74 (19%)
SET_ASH1L 1391..1531 CDD:380951 54/164 (33%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
SUV39H2NP_001180353.1 CD_SUV39H1_like 47..95 CDD:349289 1/4 (25%)
SET_SUV39H2 167..409 CDD:380930 69/258 (27%)
Blue background indicates that the domain is not in the aligned region.

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