DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ash1 and setbp1

DIOPT Version :9

Sequence 1:	NP_001246834.1	Gene:	ash1 / 40133	FlyBaseID:	FBgn0005386	Length:	2226	Species:	Drosophila melanogaster
Sequence 2:	XP_005165732.1	Gene:	setbp1 / 796785	ZFINID:	ZDB-GENE-060526-72	Length:	1438	Species:	Danio rerio

Alignment Length:	1797	Identity:	323/1797 - (17%)
Similarity:	549/1797 - (30%)	Gaps:	699/1797 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SGSENE---ETDSITDQSSQSKSIKSATQFSVQRSD-TDG-LRMRISAIRPTLGVVATKKPPKSR 81
            |.::||   :.|.:.:|           :||::.:: ::| |:::|...:      ..|||||:
Zfish    68 SNADNERWGQGDGLEEQ-----------EFSIKEANFSEGSLKLKIQTTK------RAKKPPKN- 114

  Fly    82 KMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGISKSDKVSKSKKSQISAFSSDSEDDLPLKV 146
                         .:|.....::::..|:    .|..||.|.:|:.|:     ..:.|...|.|.
Zfish   115 -------------LENYICPPEIRITIKQ----PGEQKSAKQAKNAKA-----GKEEEKGPPRKR 157

  Fly   147 HQQRAPRVLLSAIIQAAQSASKPTLDIGISSSDNELPNLVQAAIKRVESDTEDTTVEGSFRKAAK 211
            ..:|..::|                                       ..||:..:|.:..|.:|
Zfish   158 TYERPSKLL---------------------------------------GKTENVMMENTKPKQSK 183

  Fly   212 DKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPRKRRGRPKKVVPTVPA 276
            ..::      |..|:.:|...:|:     :..::..:.:.||..::|...|.           |.
Zfish   184 SNDI------LHLDWTKKLDTVGE-----VGSQEQNRTEPETKKESACTNKG-----------PL 226

  Fly   277 PGNSGP----AINESADSGVISTTSTTQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKR 337
            |..|.|    .:.:.|| |:..:...:..::||..:...::|.|...|...||....:.   |:.
Zfish   227 PEPSTPFLKTQVKKVAD-GLSGSHFGSTMSSPSTDLLAASSVNTVMSPSTDSSLFSFNK---DRG 287

  Fly   338 M-YATERVLYPPPRSKRRQNNKKTACSSSNKEELQLDPLWREIDVN--KKFRLRSMSVGAASGTG 399
            : ..||:|.....|...|::..||             |:...:|:.  ||....:.:..:|.
Zfish   288 LQQVTEQVFGNIKRKYGRKDPTKT-------------PVMHNLDLQWVKKMDRDTENQDSAK--- 336

  Fly   400 ASTTICSKVLAAKSGYVSDYGSVRH--QRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGY 462
                       .|..|..|..:...  ::..:..:...|:...|.:.|      :..||:|.
Zfish   337 -----------EKQPYSQDKSAFEEEPEKPINRLDDDNKTTTGCGTHY------TEESRSKK--- 381

  Fly   463 RSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESNEYISKPSLKSLP 527
                          ||.|:.:           ||..:.....:...:.::.:::..:|..:....
Zfish   382 --------------RRNRKVT-----------EDSMVSNAQTVQQDEKTDNTDQGCTKLKVTKKT 421

  Fly   528 TTSASKKYGEINRYVTTGQYFGRGGS---LSATNPDNFISKMMNQRKETPAPSKSS--------- 580
            ..:|.|::|           |....|   ::.|..|: .....|:.::|||....|
Zfish   422 DVNAPKQFG-----------FNLQQSKEDIAGTVTDD-AEMFQNRPRKTPAGRARSMIDVDKQTE 474

  Fly   581 ---CKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNID-----------SKLLT---E 628
               .|:|.|.....|..||          .|:    ..|:||:|:           |.|.|   .
Zfish   475 GRQSKVKDRWLYLKSQNSS----------PHK----DLNQSLSIEEPPSAFPITPSSPLYTNTNS 525

  Fly   629 IEIITSTFNSRCRIQDDRL---------TGSSGKEKLLADANK------------LQATLAAPSP 672
            :.:||.....|.|.:...|         |.:|....:..|::.            :|.......|
Zfish   526 LTVITPVKKKRGRPKKQPLLTVETIHEGTATSPVSPIAHDSSNTSKRKKHNMSKLVQLAFHKSPP 590

  Fly   673 AQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGT----PNGSGSSNGNT----- 728
            ||||.|........|.|.....:|:.|:...:.:  :||.|:||.    ||...|:..:|
Zfish   591 AQQLQLKKSDQEGVLKKRTPTKIKEVKMQNIINE--LLSTSSSGNLAPKPNVPVSNAMSTVASTI 653

  Fly   729 -------------------KRRHKKSQSNDSSSPDDHKLPLKKRHYLL--TPGERP--PAEVAFA 770
                               |:|.:|.:::.||..|:||  ...:|.||  :|.|.|  |:..:..
Zfish   654 EARFGKQINVSKRGTIYIGKKRGRKPRADLSSQQDEHK--ASDKHSLLNSSPFENPLVPSSNSST 716

  Fly   771 NGKLNA------EAWAAAAAAAKSTASTKSQAQF----NARSVKSALTPKKRH------------ 813
            .|..:.      .:.:|...||....:..||...    |.:.: ||| |.|.|
Zfish   717 TGMPSPRVMHSFSSHSAPGGAAHPVTTDTSQHDLKTMPNLQPI-SAL-PTKTHKGLLSSNWKLSP 779

  Fly   814 ---LLEQPTSVSGAGS--SASNSPLR-------------IVVDNNSISGGKLLDISPSSLCSLKQ 860
               :...|:.:|...|  ..:.||:.             |..||||.|               .|
Zfish   780 PRLMANSPSHLSEVASIKEVTLSPVSESHSEETIPSDSGIGTDNNSTS---------------DQ 829

  Fly   861 QRRGGAAKQKVS----------AAKDLVQLQSPA--GSYPPPGVFEPSVELEIQIPLSKLNESVI 913
            ..:|.|::::.|          ||  ::..:|.|  |.|                      :..:
Zfish   830 TEKGPASRRRYSFDLCSFDATEAA--IIDAKSKAARGHY----------------------QKHV 870

  Fly   914 TKAEVESPLLSALDIKEDTKKEVGQRV---------------VETLLHKTGGNLLLKRKRKKINR 963
            |...||:     ...:|:.||:..:|.               :|.|:.|.....:..|..|..:.
Zfish   871 TAVSVEN-----FFAQENLKKQKHRRKRKALQSQDDLQFMADLEELVSKFQVFRISHRNYKFYHE 930

  Fly   964 TGFPTVRRKKRKVSVEQQTTAVIDEHEP-EFDPDDEPLQSLRET--RSSNNVNVQAAPNPPLDCE 1025
            ..:|::.|..            .|.:.| .:.|.| ||..||.:  :|.......|..:.|:  .
Zfish   931 NSYPSIFRLN------------FDHYYPMPYYPYD-PLHYLRRSSDKSKRRRGRPAKSDEPI--S 980

  Fly  1026 RVPQAGEARETFVARTNQKAPRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQP------ 1084
            ::|        |:.......|..:..|...:     |....|......|.......|.|
Zfish   981 KMP--------FIQGFGCPVPGGNYYAPYAM-----PYTSMPLATSMINMGYYGQYPSPLYLSHA 1032

  Fly  1085 -PPKSEPEIRPAKKRGRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRR 1148
             .|.:.|.:|                 ||.|||     |..|...           ||
Zfish  1033 LGPTASPLMR-----------------PPVPPP-----KFHPGAS-----------SC------- 1057

  Fly  1149 KNLEAGTQPKKEKPVQPVTVEEIPPEIPVSQEEIDAEAEAKRLDSIPTEHDPLPASESHNPGPQD 1213
              |.|.::.:         |:.:|.|:..|:                       .|:||:|....
Zfish  1058 --LSASSRHR---------VKNMPHEMSSSR-----------------------MSDSHHPSSSC 1088

  Fly  1214 YAS-CSESSEDKASTTSLRKLSKVKKTYL-----VAGLFSNHYKQ---SLMPPPAKVNKKPGL-E 1268
            ..| |....:.|      .|....:..|:     :.||||.....   ||:....:.|....| :
Zfish  1089 LGSVCLHKRKHK------HKYKHKEDQYIQEREDLGGLFSGTQSPAFLSLLNERLEKNSLSKLKD 1147

  Fly  1269 EQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLP---------TRNVVPSWNYRKIR 1324
            :|.|..|....|.....|.   |:|           |.|.|.         ||....: |:..|.
Zfish  1148 KQRGKHSTDTSPKASRNYF---EVD-----------TLSSLSLSDSQHCKRTRGETLN-NFLNIC 1197

  Fly  1325 TNVYAESVRPNLAGFDHPTCNCKNQ------------------------GEKSCLDNCLN---RM 1362
            |....|.:|   |..|.|....|.|                        |..:....|..   ..
Zfish  1198 TRQPHERLR---ASQDQPLDLFKGQHLGGDDSSIHIRRHSLEDFTTYKEGSMASFQGCSEERAEQ 1259

  Fly  1363 VYTECS-----PSN---------------CPAGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTK 1407
            :| :||     ||:               |...:||...||            :|..|.
Zfish  1260 MY-QCSTAVAEPSSYKRRPKLVEEVEEVQCDMRKKCAFSKI------------LTTKKN------ 1305

  Fly  1408 LPIAKGTYILEYVGEVVTEKEFKQRMASIYLN-------DTHHYCLHLDGGLV-----------I 1454
                     |::|.:::..|.. ||.|....|       ......|.|:.||:           :
Zfish  1306 ---------LDHVNKILKVKRL-QRQAKTGNNMVKRRRGRPRKQLLSLEEGLLGQMPVLEKCVDL 1360

  Fly  1455 DGQR------MGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPS 1513
            .|:|      :.:...|.||.                        :|.:..|...:...|.|:|.
Zfish  1361 PGKRNLHTGLVPAQLEFSNHD------------------------SITDAIESVVNMARSQFSPQ 1401

  Fly  1514 EGQPCRCNTPQCRGVIGGKS-QRVKPLPAVEAKPSGEGLSGR 1554
            ..|             |||: |:::|...|| :|:.:|...|
Zfish  1402 SMQ-------------GGKNWQKIQPELQVE-RPNRKGKGNR 1429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ash1	NP_001246834.1	AWS	1340..1388	CDD:197795	16/94 (17%)
		SET	1392..1512	CDD:214614	22/143 (15%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068
setbp1	XP_005165732.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593918
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46147
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.890