DRSC/TRiP Functional Genomics Resources

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Protein Alignment ash1 and setd1b

DIOPT Version :10

Sequence 1:NP_524160.2 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster
Sequence 2:NP_001072649.1 Gene:setd1b / 780106 XenbaseID:XB-GENE-5842344 Length:1956 Species:Xenopus tropicalis


Alignment Length:1890 Identity:330/1890 - (17%)
Similarity:572/1890 - (30%) Gaps:698/1890 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 ETAAAKVLETQRAQESGSENEET-DSITDQSSQSKSIKSATQFSVQRSDTDGLRMRISAIRPTLG 70
            :|..::..:|.|..|......:| ||.:|....|.|::                     ::|...
 Frog   397 QTDESQYPQTSRDMEYRRTGPQTSDSYSDAGCNSASLE---------------------LKPVKE 440

  Fly    71 VVATKKPPK-----SRKMSTQDTESGC---------SEAKNRAVSKKV----KVKRKKLASSSGI 117
            ......||:     .:|.|...|...|         :|.::.::..::    |.:|.:|...:|.
 Frog   441 KPEEPPPPEPDSTTEQKASFSQTPERCETPGTPTLEAELQHNSLDTRIAMLLKEQRTQLHLIAGD 505

  Fly   118 SKSDKVSKSKKSQISAFSSDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISS-SDNE 181
            ..||...:.:.|.||:.||...   |:       |.....:..|....:|:|: ..|:.. |...
 Frog   506 QNSDNEIRMEGSPISSSSSQLS---PI-------PPYSSGSRYQDVTPSSRPS-STGLEDISPTP 559

  Fly   182 LPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQY----QSTLLQDFMEKTQMLG--QTVNAK 240
            ||          :||.:|..:.|:.......::....    ||....:.::|.:::.  :|..::
 Frog   560 LP----------DSDDDDEPIPGTASLCQNSRSASPIDQINQSGRKTESLDKKELVAGDETPTSE 614

  Fly   241 LAEEKVAKAKEE-----------------------TLVQTAVPRKRRGRPKKVVPTVPAPG---- 278
            ..:|....:.|:                       :::.:.:|....|.|....|..|.||    
 Frog   615 KMDEGHPSSGEDMEISDDEVTPSPITSAECAITSSSVISSVIPIPPPGFPPLPPPPPPQPGFPMP 679

  Fly   279 --------------------------------------------NSGPAINESADS-GVISTTST 298
                                                        ..|..:|...:. |.::.:..
 Frog   680 PPLPPPPPPTHPSVTVPPPPLPAPPGVPPHHILHHPPPYHHFPVMQGEMMNVLGNHWGGMTMSFQ 744

  Fly   299 TQSTTPSPKMQNENAVP-----TGSL---------PIASSSK----------PKIDMA------- 332
            .|:...|..||.:.:.|     .||:         |.|.|:.          ||.|.:       
 Frog   745 MQTQMLSRMMQGQGSYPYHHFMGGSMQFGNQHPYRPFAISAHLTRGQPWPPFPKFDPSVPPPGYE 809

  Fly   333 ---------------------------------------------YLDKRMYATERVLYPPPRSK 352
                                                         :.||:....::.|.|....:
 Frog   810 HKKEDPHKATVDGVLQVIVKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERLAKQSLTPVKSGE 874

  Fly   353 RRQNNKK--------TACSSSNK-EELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICSKV 408
            .::.:|:        :...|.|| |.|..:.:...|.:....||.|..|.......|:       
 Frog   875 SKEEDKQKTKEHITSSLLESWNKGEGLGFEGIGLGIGLRGAIRLPSFKVKRKEPPDAA------- 932

  Fly   409 LAAKSGYVSDYGSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSC------------- 460
            ||.....:....||..:......:....|.||..|:....:..:||..|:..             
 Frog   933 LAGDQKRIRPSHSVDDEDEESERDRDISSTASDLSKKDADAVNNRRRPARPLDSEGEEEVESEGD 997

  Fly   461 -GYRSDCKESGK----------SGLRMRRKRRASMLLKSSADDT----------VEDQDILQLAG 504
             |..||.::|..          |.|..:::...........|||          .|::|...:|.
 Frog   998 DGETSDKEDSSSEKEDQDDGSVSALSSKKQLYGDKEGDDEDDDTQSSGKEEDLVSEEEDTTSVAS 1062

  Fly   505 ----LSLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYV-----TTGQYFGRGGSLSATNPD 560
                :.....||||:||.|     |..:....::..|....|     :..|..|:...:.....:
 Frog  1063 SRAEMDSSDESEESSEYES-----SSDSDEKEEEDDEEEELVFGDDQSEDQDLGQEYEVETDREE 1122

  Fly   561 NFISKMMNQRKETPAPSKSSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKL 625
            :|..:.:::....|.......:.:.::             |.....|...:...|.:..|:|..|
 Frog  1123 DFFRENLSECSSLPKAGDVELEDEMQK-------------VEEDVARQTTQETLHLRKKNLDVPL 1174

  Fly   626 LTEIEIITSTFNSRCRIQDDRLTGSSGKEKLLADANKLQATLAAPSPAQQ-------------LT 677
            :...|....|.:     :.::|.....:|::..:..|      ||||..:             |.
 Frog  1175 VESKECKQDTLD-----KVEKLFAVPMQEEVFKEHEK------APSPMNEEEEYIELQLEPVPLV 1228

  Fly   678 LNGGGPASTLSKPLKRGLKKRKLSEPLVDFAMLSASASGTPNGS-GSSNGNTKRRHKKSQSN-DS 740
            ..|..||:               .||::...:       ||.|: |.:....|....|.|.| ..
 Frog  1229 PEGAAPAA---------------QEPVIIRPL-------TPTGAFGETGPVLKLEEPKLQVNLTQ 1271

  Fly   741 SSPDDHKLPLKKRHYLLTPGERPPA----EVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNAR 801
            .:.:|.:|      |..|||....|    ||.|..|                             
 Frog  1272 FATEDEEL------YPRTPGRDTAAHSDTEVTFQPG----------------------------- 1301

  Fly   802 SVKSALTPKKRHLLEQPTSVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSL----------- 855
                                                          |.::||||           
 Frog  1302 ----------------------------------------------LKVAPSSLPFLPSHNKEEE 1320

  Fly   856 CSLKQQRRGG-AAKQKVSAAKDLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVE 919
            |.|..::..| ....|:.:.:||.:         .||       .:|.:..|.|.:|..|:....
 Frog  1321 CLLPPEKHAGHLTVTKMLSEEDLPR---------TPG-------RDIVVKSSHLGKSQSTETVPA 1369

  Fly   920 SPLLSALDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFP-TVRRKKRKVSVEQQTT 983
            :|...|        ...|..:..|..|..|.......:...|..:|.| |..|.........::.
 Frog  1370 TPGSDA--------PLTGSSLTLTSPHIPGSPFSYLSQSPGIINSGIPRTPGRDFNFTPTFPESN 1426

  Fly   984 AVIDEH----EPEFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVARTNQK 1044
            ::...|    :|..|..||  :|.:|..|: ::.:.:.|:|      :|.|...|         .
 Frog  1427 SIFPCHPSGKKPSVDEPDE--KSFKEPTSA-SLTMNSVPSP------IPFASPPR---------G 1473

  Fly  1045 APRLSV-VALERLQRPQTPA---------RGRPRGRKPKNREQAEAAPQPPPKSEPEIRPAKKR- 1098
            .|.:.: :..:.|:...|||         .......|.......|:||.||      :.||:|| 
 Frog  1474 LPHMDIRLGADDLESSDTPAYLSDKLLSEESECEFTKVHLTSTDESAPSPP------LPPAEKRK 1532

  Fly  1099 GRQPKQPVLEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKIRLKRRKNLEAGTQPKKEKPV 1163
            |.:.|:|:......|    :|..:....:.:.:|             ...|.:..|         
 Frog  1533 GDRSKKPLSAHEFET----EKNYETSSAVAMSEG-------------ALGKQMFIG--------- 1571

  Fly  1164 QPVTVEEI--PPEIPVSQEEIDAEAEAKRLDSIP--TEHDPL----PASESHNPGPQDYASCSES 1220
            ||..|..|  |..:|:.          .|.||:.  |.|:|:    |..|..|    .:....:.
 Frog  1572 QPDAVSGIKDPAAVPLD----------FRNDSLSENTVHEPIIQKVPLKELEN----QWNEVLKE 1622

  Fly  1221 SEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQ-SLMPPPAKVNKKPGLEEQVGPASLLPPPPYCE 1284
            .||         ::|.||:.  ....:|.|.: |.:|.|          |...|.::..|     
 Frog  1623 EED---------ITKHKKSR--NSRHNNRYDEFSTVPSP----------EFSPPRAMFKP----- 1661

  Fly  1285 KYLRRTEM-DFELPYDIW---------------------------WAYTNSKLPTRNVVPSWNYR 1321
                |:|. :..:.||||                           |  .|..|        |.|.
 Frog  1662 ----RSEFEEMTILYDIWNGGIDDEDIKYMCITYDRLLQQDNGMDW--LNDTL--------WVYH 1712

  Fly  1322 KIRTNVYAESVRPNLAGF-DHPTCNCKNQG-----EKSCLDNCLNRMVYTECSP----------- 1369
            . .|:||:...:....|. :|.|...:::|     :|..|...:|....||..|           
 Frog  1713 P-STSVYSPKKKKRDDGLREHVTGCARSEGYYKIDKKDKLKYLINNRSLTEELPIDTQGKSIPAQ 1776

  Fly  1370 --SNCPAGEKCRNQKIQRHAVAPGVERFMTADKG----------------------------WGV 1404
              ::..||.:.|:::          .|.:::..|                            ||:
 Frog  1777 PQASTRAGSERRSEQ----------RRLLSSFTGSCDSDLLKFNQLKFRKKKLRFCKSHIHDWGL 1831

  Fly  1405 RTKLPIAKGTYILEYVGEVV-------TEKEFK-QRMASIYLNDTHHYCLHLDGGLVIDGQRMGS 1461
            ....||.....::||||:.:       .||.:: :.:.|.|:       ..:|...:||..:.|:
 Frog  1832 FAMEPIIADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYM-------FRVDHDTIIDATKCGN 1889

  Fly  1462 DCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQ--PCRCNTPQ 1524
            ..||:||||.|||..:..:|....::|:::|:.|...||:||||.|    |.|..  ||.|....
 Frog  1890 FARFINHSCNPNCYAKVITVESQKKIVIYSKQYINVNEEITYDYKF----PIEDVKIPCLCGAEN 1950

  Fly  1525 CRGVI 1529
            |||.:
 Frog  1951 CRGTL 1955

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ash1NP_524160.2 PHA03247 <1018..1281 CDD:223021 56/282 (20%)
AWS 1340..1388 CDD:197795 12/65 (18%)
SET_ASH1L 1391..1531 CDD:380951 46/177 (26%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
setd1bNP_001072649.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
RRM_Set1B 119..211 CDD:409965
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..478 17/101 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..637 27/155 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..696 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 926..1148 38/233 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1341..1386 12/68 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1420..1464 9/46 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1512..1553 14/50 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1627..1655 9/39 (23%)
N-SET 1669..1811 CDD:463344 27/162 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1766..1790 3/23 (13%)
RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827 1788..1793 1/14 (7%)
SET_SETD1 1805..1952 CDD:380946 41/157 (26%)
Blue background indicates that the domain is not in the aligned region.

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